@MDX4E:00665:05793
CTGGGGTGTCTGGGCCATCCGAACGGCCTACGTGGGGTGGGCCGAGAGCCGCCTCAACCAGCGCCAGTTCCTCAGCGTCTGCATCCGCTTCGTCGCGATGTACCTCGTCCTGAGCTTCTTCCTCCTCTCCTGACCTGAAAGGCACGACCATGCAAAACCGCATCCTCCATTCCCGTCTTGCCCAGCGCGCCGCTGTGGCACTGGGCGCCGCTGCGCTGCCCGTGCTGTCGTTCGCACAAGGACTGCCGCAGTTGGAGAACCCGACCCGCGGCACCGGCAACGGCATCATGGAAACGATCAG
+
BA@@A9ABBDBBC=B?BBB?BC9CB8B?B@A@7777&7=?4A>BBBBBB>BC>BBB>B>A>???.57:5;7=>A@@;;;>>DCJF@C@?=@@?BBBDCCBBBB@BABCB?ECCBB<9<C>C?BB?BBBA>BBCC?BBBF=A>ABBBAA>ABCBBBB:B=@ABBB@BB?BB?BC>CBAB>BBC>AAB>:;;;?>>>;;5;????B;888=>>>?@CAB>>>::AAA@>>AA?;;;;?;;5=<@@@@A<AAAAA<A<A==4::0;>=?9???<A::7;;?A:>>:>>>>>AC05516=9<8::
@MDX4E:00665:05807
CGGCCTCGACCAGCACCACGTCGAGCCCGGGATTGTGCTCCTTGAGCATGATGGCGGTCCACAGGCCGGTGTAGCCGCCGCCGACGATGCACAGGTCGGCGCGGGTATCGCCGGCCAGCGGCGGGCAGGGGGCCGCATGTTCGGAGCGTAGGGCCTGGTCCAGCCAGAAGGGTCGGAAGGTCATGGCTGTGCTCTCACTGCGGACGGGCGGCGACGACGATCATTTCCACCCGCCAGCGCGGGTCGATC
+
:;456;<==C?AACBB@BCBBBBBBBA<AC9;:?BCBBBB@C@???BBCBBBC@BB?BB@BBAA>B>B@CCCCA@=AA?BB?CCDBBBCBDCCC?CCC@CCAAA>A@A@;;:<@C@BCCB@BDC>CBEFFG5A>ABBBBCACD@AAACBBBB<A=@B>BC@BAB>BCC@CC>BBB@D?C@CCCCC@CBBCBBCCCBCBBBB?:?98739>8=@BABCBBBABAAA<A?BBF>BB?BBCB@@A9>>>A>=
@MDX4E:00666:05762
CACGCCTCAGCCACCTGGCCGCGCGCCTGCGGCCGTTCCTGCTGAGACTGCCAAGGC
+
AB99;@CBBBB@BC?BB?C@CBA?AC@CD??<??@@=A?A@@>0//////4.3-3-3
@MDX4E:00666:05765
GGTGTTGCTCAGCCCGACCTTGCCGACGTTGGCCTGGCGGATGTGCCCGATGACCGTCTCGCTCTTGATCGGGAAGCGCTGCACCAGCCGCGCCACCTCCGAATCGACGCTCGCCAGCGGGTCCTGGAACAGCCGCACGCCGCGTCCTTCGTAGAAGGCGATGCCCCAACCGTCGCGGTGCGGGCCGGTGCCGCCGCCGCGCTGCATCAGTCCGGTGAAGCTGAAGACGATGTCCGTCGGGACGTTGGCGCTCATGCCCAATAGTTCACACATGGCTCAAACCTCCCTGAGCAAGGCTGTACGTAG
+
C@CCC@CBBAAAAA<ABB>B=?=<>>>//*0:=;7;7;@8;<==>;D9D>==A@=@===BBBBBC?ABAABB<B>BBBB>>>CC>CCC<><@<177:=><AA:<=B??>>A@CC>BB@@@<@B@CC==9B?>>9=@@>B>;?===>:>9><=<AA7;79>;<<<<<3<=D;@>AA?>:?@@@B9>:>:=>=8=?7=;:>B>;=A@@@@AA>>8<8<>>;A>>>>9>>>===>>A:??AAA9A>>?;A9>>>;;;??AA9A:BA>>9B@<;;AAA;AA<;;599;<<6=A===>5868<<<=@>@AA
@MDX4E:00666:05784
AGCGAAGCTGCGCTTCTAGGAAATTGAGAATGCCGCCGTACGAGCTGATCATCACCGACCCCCAACCACGACTAAGTGCCTCCTGCAACGGCAGAGTAGTAATGTGCTCGGAAACAACTTCACGATCTGCATCCTCGGGAGACGAGACTGGCCGTGTAGTGTCGGGATCAAGCAACAATTTCCGCTCTGTCGGGCTCAGATGACGGTACCCTCTTTTCGCAGTAAACCCCGCCACCCACCCCACGCCATCGTCTGGAAACCAAGCCCAACGATTGTTTTCCCCA
+
CCDBB@BBBBBBBC<A@AA>AA=B@???B?BBB?BB=BBBBA;CAAC>>????AA=AAAAAA/A<>:=;CDCCC?BBCC@CC?BBCD@AB>ACCCBBBAAB>CBBBB?>?;?C9>>:;=:=>>CAAACAA>;;59<<<7>>>@A===?==:>=A???A@@@A@@@8>???9=>A;AA7==7><AA@>@@@@@@9@A@>@AAAAAA<A::;3;8?AA5AAC???@@9?@?6?D=>>>9>AAA6=>AA<A@@AA@;<5991:=D8;:D:B:<=CB=@@@@6@AA5>
@MDX4E:00667:05791
ATCAGACAGCTTGTTCGTCATTATAAATACTCATGGCATGCCATATGTACAATTTTGTGAATTGCCTTTATGGTTTGTATATATGGCAAATTCATACGATTTGCCGTAATTGGTGAAACATAAGGTACAGCTATGGAAGAGTCTGGAATAGTGGGGTTCACCGTTACAGGTGCTGTAGAAAAGGTCACGGACTTCCGCACCGCGCCGTTCTGCTCGCAGGCGTCTTCGCGCAGATGCTGGGTCTGGAAGACATCACGGAAGACGTGGTGCGGGGCTGGGTGGAAACCAAGACGATCCCGACTGCCAAGATTGGCC
+
BBCDCCCCBBB>AA?B?=>BC?BBBB<?>AAA@BB>BBBBC@DCCBBBAAA=ADD8@@CC@C?AAAEE=BBCBDF>BBBBBBA9:59@B;A?BBCDCBBBL>CC@BBC?C@D?AADD>AAAB>B>@@@@@ABBBB?C?BAA===@<B?BCBBBDD8=8@AB=AA9<;AA=>==AAA@@@>>2858@@@A;??=9>9>AAA<@>>A7=;6:8;=>@@ABC=::;AA<===@AAAA>>>>>E9????<A<AAAA@@@>><>;>>????=@@@AAA5==<<6//)//)/6:6:@??>;;;1;;;;BB:>:=@A:>:==
@MDX4E:00669:05778
AACATGGGCTGCCCGGCGAAGAAAGGTATGCAACAAGGCAGCGGGGTCCGCCCTGCTGCGGGACGAGGCGCTGGTCGCCGAGATCCTCGATGCCGTGGTCAGGGCGGTCGACGTACCGGTCACCCTGAAGATCCGGACCGGCTGGGACCGGGACAACCGTAACGGCGTCACCGTCGCGAAGCTCGCCGAACAGGCGGGGATCCAGGCTCTTGCGGTGCATGGCCGGACCCGCGCCGACCTGTACACCGGGGAGGCGGAGTACGAGACCATCGCGGCGATCAAGCAGGCCGTGTCGATACCGGTGTTCG
+
B<?=@<@4<<<<C0;5;595994)43444333-4;8<8444;;;;1::6:=B9BCBCBAA@:@@@:=8@=<AA?BBBB?BBD=?85>>597==975238889=-53033./.33:?;??>566D9>>><????:>;=>:=<@@?>48818>6:::9=:<AA9//*//.5=@<AAB:66>9>>??>C?BB=A?>:>>A?9A775;@=@CBB@CBHAHAABAA=A?B><;;0;EBA=@BC?CBBBCCF@BII9BC?A@=ACCCBBBB@@=@B??@B@BCCCCC@BABB=?=?CDCC@@ACC@B?B>><>B
@MDX4E:00669:05794
ATATTTTTACTTTCAGTATTCTCACAGAATTTTCTGAACATCCATGATTGGATCGACTCGTTTAAGTCATATTCTCCTTGAATCCAGAAGGAAAGTATGACCCAGAATGATGCAAGACCTTCCAGATTCTCAATGCTGTGAGCTCGGTAGAAACTATTCCACTGGCTTTGACTTCTAGCTTTCCCGTAAACTTTAAGATAGCGATTTAAGTGCTGACCAAGTTCAAGCGTGCTTCGTTCATCGAGTGCATGATTCAGTTCAGCTATACGCTTAAATGTAGGAGAGGTATAGAATGCCAATCCAACCACAGGGCTACTTACTAT
+
B@99999';@@A<BFBBBB>BAABBBBB>BBB5@@CC8CBC@<?;5:A6?6@>:;;>>@@@D:B<@:>:<??9>=A=C<>>;>A=>>>8>;>D7=>D>=66618==;==:;:>?<@@@<@<@<@><><AA>>:>?@:;;AA@A@>><>??=A3>>>>4?4?@@A;==>8=HBB<??@?==>8>?9@?@?9>>>9><@@==<=;678-88=?@A@A@@<@<@B=AA;>:::>?B<@??<A@;;;??>>>A==::8;??D=>>>@@A@@??>>8>A9788AA:?@;;7:A==>>;>>><@=AA<A<A<A@@@@:@>>>>=CAA=>
@MDX4E:00669:05798
TGGCATTGAAGGTCTTCTCGAAGCGCTGCTCGGCGCTGGCCCACTCGGTGGCGTCGTGGAGGATCAGCACCAGGCAGTCGGGCTTGTCCTCGGGGGTGGTCAGCACCAACCCGCGCACGCGGTGCACCCAGCGGGTGTCCTCGTCGGCGGCGGGAAACACTTCCACCACCACGTCGCTGAAGCACTCGCCAGCCACCAGGCGCTCGGCCGGGTACTGGCCCTCCTGCAGCGGATGATTGTTGCGGTAGCGCAGGCGAAAGCGCTCGCGATACTCGCCGGTATCGGCGCCCAGGCCTTCCAGCGAATCG
+
@C<CBC>BC<@<@@@<?BB==9<CCBAAACCB7BAA??;?@8?CC??99:5:=A??=?;>>;>?@?@@@@=8838AA>???9?B:>=A=AABDDD/>>;>AA@@<=9=6;;2///==;A??=@??ABB:C?@@A::;;=9=>?:;;:==8<<<.::/:==<6<9==8==:=AABDDDDAA<AAAAA?AA=AAA=BA===:>A@A>><><@@9>>A@@<??9?D;><????@:AAAAA<AB=>>>;@BBAAAAA;A;<<7=@?@A@>>>@@@@@D>>9=9>>>>>:>>>?7?@;A;A;A7<<>AA;AA?
@MDX4E:00670:05762
GCTGGCAATGCCCGGCCAGGTGCGCTTCCAGTTGCGCCACCCCCTGTTTGTCGAGGGCGGTGAAGGGTTCATCGAGGATCCACAAGGGCGGTGCGTCCAGGTACAGGCGGGCCAGCGCCACGCGGCGTTGCTGGCCGGCGGAAAGGGTGTGGCAGGGAACGTCCTCGAAGCCACGCAGGCCGACGTCG
+
CCCC?998:@@B=CAE@BB@BCCBAB?A>@BC?B@AA@CCCCC5CCCD?CBA@@@@:@B@GFF@CD?DAA@A@BBB@BBBACCC?CC>BB?BCAAAC?BB?BBBAA=:99283??CCB<AA;8818==4;;;;6;=@=>><>A9@A9??<=8<==>7><>>>A=???A;>>7;;BBBA?B@CCBCCBB
@MDX4E:00670:05776
TCTAGCGATCCCGGGCATCGCTTCCCGGATAATCTCTAGTGTCTGTTCTACAGGGACGTTAGGGGAGACAGTTTCAGCTAGCCTCACTTGCGTTAGCAGCTTGTGTCCCTCGGCCACTGTAAGCATTGTGACCCATGTAGGACCACTTTTCTCATGCTCCACACTCACTAGGTCAGCATTGATAAGCTCGACTAGGCCAGTAGACCGATAACCCACCTCTAGGCGAATTACCATGCCTTCCCGCAAGCTCTCCCGGCTTGTGTGGCTCAGGTTATAAATACGGACAGCACCATTGGAGATACGTTGCTTGCTGTCTGCGTTCTTCTCTACGTTGAAAACAAGCTGCAAAGCATTGTCATCAGAGAACTGGCCTTCATACAGAAGAGCAACCGAAGGGTTGTCG
+
BJEA9;;CCCC<AB<ABADCBC?CC>C@CBB?BCBAA>><@@@@BB?BCCCCCB;AA;;:;DGE<CCCCCCBD>CCAA@ECC@CBBBB=@@@B?BBBBBBB9;;AABC>@@?>B<???AAB?BBBB?BBB>BC>D@A@A>:??8===<</<878>>>;;3:;::=<:;;@@=@B>;;;B<>>@@=B@@?@ACA>>:>:=BA???@=@><<5::1:<9::;::6:A@=A<@@;@98817:?A:@@@;??@@@DC7>:>D<???;;7;>>>A<?8<:990::9=:>>A@@@A;??=B<=====:;;:===598<?=>;;;@A<>>=A@==;;;=49:99*8;9:777:>>7>>>>=AA??;;;B>>><A@@;@=B;?>AAAC;:4667//+/6::7=;2<6:9:/
@MDX4E:00670:05800
GGGATTGAACTTCATATAGTAGTGCAGCACCGCCGGGATGATCCCCGCCGCGCCGTTGGTGGGCGCGGTGACCATGCGTCCGCCGGCGCGTCTCCTCGT
+
CE>CC=BB@CC@CBBABBBBBBBBABBCDD?BA=CF>B@@@BBCC:BB?BBBB@BC?B@BBB=BBAA=A;@??A@ABDBA>AA>A:<::.----0---.
@MDX4E:00670:05806
TTATCCCCCAGGGTCGAGCGCGCGCGGGAACGGACAGAGCATTTTCCGCGCGGTAGAACGCGGGCGTTCCCCCTGATGAGGACGATCATGAAGAAACTGCTGCTCGCAGCGACAGTCGTTGCGGTGGCCGTTACGGCGCAGGCGGCGCAGGACCCGGAAGCAGTGTTCAACCGGACCTGTGGCGCGTGTCACGACGGCCAGCTGCCGATGGCGCCGAAAAAGGGGCGACCATGCCGCCTGGAGCCGCGGCTGGCCAAGGGCATGCCGACCCTGGTCCAGCATGTGACCAACGGATTCA
+
@8@>>>>>0@AB=BBBCD@??BBCABB<B@CB?BBBBBA@><<<5>;@@B>>:=AAD<CCCCC>BCC=AAAA1ACBBACC@CCBBBBCBBB?@BA:@@@BBBCCCCCCCCCCCCBCCBB>ABD@CB?B?BE@CAA>ABAAC?8758??><:<;;7<;?:>>??@?D<?>6;6;:?C:>=:;5888==??B>>===>;>;????>>:>>BB=A?>:88888(552&2888277..).72..).55265729>>9>8=6<<7;A@@@<@=<=8==:=F>=>=?===>==:=<AA=@@<@A
@MDX4E:00671:05778
GCATGGTCCTCGACGGCCGCAGCATTCGTTGCTTTCCGCGTGGTGCAAGCCATCGGCGCGTCAGCAATGCTCGTCGCGATGTTTGCAACTGTTCGTGACGTGTTTGCCAAAAAGCCGGAAGGCGTGGTCATCTACGGCCTTCTAAGTTCGATGCT
+
BBDCC@BA@ACAA8968=A?AACCC=?AC@CA@@<A?CBB<=:<@886<@=ABBB597A????@>>:BC@B@BB@=;>BBBBB<B@@<@BBC?BABBBAB>>>>/99/5666(/9)/)/)/)/<9=8====A@>>=<A<A:??A;>>9===;;;@
@MDX4E:00671:05789
CGCGAAGGCGACTACGCCCACGCCGGGGTGCCATTGCTGGCGCTGGTGGACCGCGATTCGTTCTATGTCAGCGGATACTTCGAGGAGACCAAGTTGCCGGGCATCCGCGTCGGCAGCCGGGCGCGGGTGGAACTGATGAGCGGCGAGCGCTTCGACGGGCGCGTGCAGAGCATCGCCCATGCCATCACCGACCGGGAGAATGCCGAGGGCTCGCGCCTGCTGGCGAACAT
+
ABCBE>A?ABBBCCBBBC<B@BB?B@@7??@=BC@CFBB@BBABB@BC>BB@CBBBC@DBB>AB@BBB@??@A<ACCBB@BBBB?CAAC?C>?@=AC@BB9BCCC@CCCCDD>A@@@<@C9>>==>7=@=A?CCCCBBBBBB?BB@@@BBB?AA@@@C;BBA>@@BBB@@@BBB>==7=AAA;A@@@@;@>>9>>7>>>;@AA6<555,5==>@@@;@AAAA<A@@;AA@
@MDX4E:00671:05792
CCGACGGTCTCTACCTGGCGCTGGAGAACCGCTACGACCTGGTGGTCCTCGACGTGATGCTGCCCGGCCTGGACGGTTGGCAGATCATGGAAGTGCTGCGCAAGAAGCACGATGTGCCGGTGCTCTTCCTCACCGCCCGCGACCAGTTGCAGGACCGTATCCGCGGCCTCGAACTGGGTGCCGACGACTACCTGGTGAAACCCTTCTCCTTCACCGAGTTGCTGCTGCGTATCCGTACCCTGCTGCGCCGCGGCGTGGTCCGCGAGGCAGAGCAGAT
+
C?BBBB?AABCCCB>BA?CBBCC@CCD@B?CAABBCCG@CC?@@>@C?BBBBBB@BCCB@BBBB<B?B???<?A@=A>A=BCCCCCCCC?B?BBCBBBBBBB?BB?BABBCC@ABBD?B?>>>DDC@C<@@BC@BBB=BAABB?BBB?BC>>;>>:>@=<=:?7738<@@CC@CDCD=CBB????000@@@<BB?DCAD9@@9?;@CB=@=@AA;@???;A?AABDCABABBB@BBBBB>?;;BBAAA:=>B<?>==8=@;===8839BBBBBAAAB
@MDX4E:00671:05807
CTTATCGGGAATGGCGGAGTTATAGGAGGAAAACCACACTCGAATCCACAGTACATCTAGTTGAATTAGCCGCTTATTGAATTCATCCCGGATCATGCCTCCGGAAAGAAGCTGTCTCTCAAGCTCATTCCTATAATGCGTGACTACTTCATTAGCCACTTTATCGGCATATGTTCTTCGGCGTTCATCTACAAGCTTAGCCCCTGCAAATACATCTTGAGGAGGCTCAGTGAGGAAACTAGGAGCGGCTGTAATTGCAGCCGTTAG
+
CC>BCFCD>C@CCAAA?@CB@BBBC@BB@BCC9C?BAAA@BBB>AB?BBBBB@?@BBCCBB?BB@C@BBB>@@A?BC?BB@D>@@@@@8@<@@@@9:9?CC?B@BB<AA8::BBBCCCAAA>AABBBD?C?BBB@>566::;;;;>>=<??B=AAA8=>AD;CA::8:@??>==<@@:><;;;:<A@@@A>>><??@<>>>DD3::@BB:BBBAB@@8;;C>AA?@BCBBBA@@<?@<ABBB?A?8849?AAA?B7:8DCC>@@?BA
@MDX4E:00672:05764
GTAGTGGTTGGGCGTCAATTCGATCGGTGTCACCGGAATGATTGGAAGTATTCATGGTGTCAGGCCTGTCGATGTGTTGGTTGATTACCGATACATGATCATTAGCGTGTCGTCCAAAGATGGACACTTGACTGGAATGCTCAATATAAACGCTTCAAGGAGTTATTTTCTCATGCTCAAAAGAACACTACTCAGCGCCGCTGTAGCTTCGGCACTGTTTGCTGGAGTCGCGAACGCTGCCGGAGTGGTTGCTATTGCCACAAGCCCCACTCTGGAGG
+
CCCCBC@C@BB=BCCBB?B>BC=7::ACBBAAB?B=A=BBBB@C?C>AABA;?ABB>BC9A@C?C?CBBC@AABBBB?B<@<?@@7>>?BBABBBBBBAAAA<@@??>>;<<<=49:2:ACC@CBAAB@BBBBC@C@CBBBBB=?A99929A@@?B?<?=>>>9::9:2:A?BBBB@@@@@6@A?@AB@@>??AA???:??BCB>>>B?@A?>??BBCE<B@@@?BBBBCCB>;>?;??C@C@AAAB?B>?@@=?:>>8=??8<79:19>A@@A>884
@MDX4E:00672:05786
TACGGGCGATGGGCATCGATACCGTGGTCTGGCCTGATCATGATCACCGGCCACGACAACTACGCCGAAGCTGCACGCGCCCTAGCGCTGCCGCTGGTGGCGCAGCCGGAACTGCTGGAGCAACGGACCTGGGCAGCCATCGCAGCGGGTTGGTTGCTGGCAGTCGCGCGGTTTAAACGATCTGGCCGACCAGGGCCGTTTTCGGAG
+
@CCCD<BBBBBB=CBBCC=BBB?A9959A==5?8@@?CBBABBCB@@8?8?3::???B??999BB=AA>A@???C=>:??B9@BBBBBC?=7;@CC;>>:576>>>;?=C=@>>>??8=<9:6;=<>?<>>>8?==<5:;==>>=8//(/5939)..5709@;;;>==<?9>A5<<6<88::;A;D9=;;7:?=0;73333)--(-,
@MDX4E:00672:05788
TTCGGCAGACCGTCGGCGGACTGACCTTCCCGAAGAATGGCGTAGGTATATTCGCCATGCACGGGAATGGCCGCCGCATCCAGGCAGCGTTGGCATACCATGCTCACCTCGGTATCGAGCTGCATATGCATGACCGCCAGCTTCTGGTGGTCGCGCTCGAAGGAAACCTTCACGCGCACCTCACCGGCATCGCTGGTCAGTTGCTCGCATACACGCGGCATATCGGCGAGCGCGTACACACCCTCGAGGGTGGCGCCGCGGTCGACCAACTTGCGCGGATCGATATGAGGTG
+
@>CC@CBBCD?A@BB@CC?CCABBF?C<>>8?C<???BD@CDBBB?BBA@B@BAA<?>?>ABBB=B?CD=D<<<7;??AA;=>;>><;=><?<@@@??:?688??@@<AAA=AABB>>>?>>=@@A;;;CAAAA;??;AA@>:?AA=??<?888>>A@@@<@5>:17375::>==@@BD<AAAA<A====>AABB:>@A@@:>>A@@@@?@?=<<9:69>B@>>><@@@=>>CA>:;;:;@@6;;;@@@8@D6;;=;>@@<>>>=?=B:==<AB@@@=???BCCCDB??<?A
@MDX4E:00672:05789
CTGGAGCCTCGACGAAGAGATCCAGGCCGCAGTGCGCACCCCGCCGTCCACCGGACGGATGCCCGACGACAAGCACGACGCCTCCTGAAAACTGCCGCCCCGACCGCTGGTGAATGGAGAACAACACCAATGAAACGTCGCAGTCTGCTCAAGGCCTTCACGCTGTCCGCGTCCATCGCTTCCATGGGCCTGTCCTGGTCCATCCAGGCCGCCGAAACCATCAAGGTCGGCATCCTTCACTCGCTGTCCGGGACCATGGCGATCTCCGAGACCTCGCTGAAGGACATGGCCCTGATGACCAT
+
BBDACCC@CBBBBBC@CCCCCC?A@?B<@AACBCBBDCGJJ:BB@B;;8;C?C@CBB@DDCCG=CB>000=9=;??C>>00+00*/<===2>@@@79599*4=98:;;>7<<<7;@<<AB@BB?B@@=??CBBB>BBB:::@999AABCCB7<8;=B=BBA?@?FCB?BDCBB?BBCBA@>??B;;;0;:=AAA???<?A>ACE@BB=B@A@=@@@9@?BCCB7;6;A@?ABBB?B?BBCBBBB@@??;?C=@A>=??;?@;;;>>=>==@@<AA;;;BB:=:>???@;??8;;;>ABB=AC
@MDX4E:00672:05800
GATCTTCCAGCCGGAGAGTTTCAGCATGGCATGGCCGAGCGACTCGACCAGGGTGTTGCGAGGCAGGTAATTGCCGGACATCGTGCACCTTTCTTATGGCAGGCCGCTCACCGTGGCGGCCCTTCTTGTGGCGGTAGAGTATGCGCGGCGCGGCGCTTCAGCGTTGGCAGCGCGGGCAGTACACGCTGGCGCGCTGGCCTAGGCGGATCTCGCGCAGGGTGCTGCCGCAGACCTTGCAGAACTCCCCGCCACGGCCATAGACGAACAATTCCTGCTGGAAGTAACCGGGCTGGCCGTCGCCGCCGACGAAAGTCGCGCCAGGGTGGTCCGCCGCGCTGCGATGGCGAT
+
BBACC<C:CB@8<8<;<;;;5;0////6073489@==>>>@A@@::;?6;<@3@AA;>@A9818AA<@@9?9?@?B>BBCGCCCCCBC=@@;@C@DCCFCCC@B@BBBAAA?BA@;;:4:>8@:<=+0/0*//)79:====BB@@9=6:0./688774695227375:@=55565(5@?<@999A?@?>B@@??9939<@@A>AD?B?>>===?>>@D:>>>>BB9?>777><>87733828=?>?1:>022=8;9?<;9353;6;;7<7:69988827655616599(///(/4999680855988222'27553//(/55.5<6;@052277962225522+3337
@MDX4E:00674:05762
CGCAACCGGCCGATCATTCCCCAGGGCGACACGGTGATCGAGGCCGACGACGAAGTCTTCTTCATCGCCGCCAAGGCCCATATCCGCGCGGTAATGGGCGAGATGCGCAGGCTCGACGACAGCTACAAGCGGATCATCATCGCCGGCGGCGGCAATGTCGGCGAGCGCCTGGCCGAGGCCATCGAGAGCCGCTACCAGGTGAAGATCATCGAGCGCAGCCCGCTGCGCTGCCGGCACCTCGTCGGATACCCTGGACAGCACCATCGTGCCTCAACGGCAGCGCTTCCGACCGGCG
+
CCBG>@=@=@<@DBB@>4::;*48:1:;ACC??=@@?@AAAA>A?BBA788DD=A??98;=8<??:;;<?=:?3738D5==;;;9=;;;=:<=:=AB:AAA?????CBAA;@@BB@>>>@>>>??>=:>==8====?@?;;;A5;5;=4;93:>5858AA4>=A<;=@=@@<@<???9=9<>A=676//+/<<:;5;;6;BE=B@>>=;;;@?;;;>888-8=;;;====A:=9=>>8=888>?<?@?@?9?B:=>CA@;;7;=::777577;<>?;;:::>>>=@7<77)/)/6
@MDX4E:00675:05768
GTTCGGCTGGCCCTGGATCAGCTTGATCAGTACCAGCGGGTCGACCTGGGTATCGGCGGCGAATTCTATACGACCGCCCTGCGGTCCGGCATCGACCTTGAGGATTCCAAGTTTTTCCGCCTGCAGCTTCAGAAGGGTCAGGCGCATCAGGTTCTTCGCCGGATCGGGCAGGAGCCCGAAGCGGTCGATCATCTCCACCTGCAACTCGCGCAAACTCCTCGTCAGGGCGTTGGCGATGCGCTTGTAGAGGATCAGCCGGCATCAGGCGTGGGCATAATCCCTCGGGGGATCAGCGCAGGCAGCCGCAGCTTATCAGCC
+
>=7;;9===;>A8==:=CCA<BB@ECCBCCCCE?AA;::.:>>9:28AA:BBBAA89929<=3919>=:;::<=<@??7?888;?B=B=?;;:=:;/816<>9?@<>:>:=====+=;;:5;;??@@B=A@>>;>A:AAAA<A?????@A=A<@@<;;;:><??@@C:??@;>;;;6;>=AAA<=>>?@@@=;;;;?D9@@;;59==<;8///'/.627644-..3-359381;;>@@@???;??>;:66:///661649///785;@>@@-//66/999.::;BBB/A>==>@@?==:===?=@>>===:9666,*(
@MDX4E:00675:05773
TCGCAACGTCAAGCTGAGCGCCGGTGTCGATAACCTGTTCGACAAGGATTACACCGAGCACCTGAACAAGGCCGGCGACGCCGGCTTCGGTTTCTCCGCCAACGAAACGGTTCCCGAGCCGGGCCGGACCTTCTGGACCAAGGTCGACTTCAGCTTCTGAACCTTCAACGAGGCCCCGTCCAGCGGGGCCCGCCTTGCCTACGTGCGCTCCGATGAGGTGATCCATGCAATCGAACGAAAAGAACGGCCGTGACTTCTATGCGCTGG
+
@CCCB@BCCBC@CCCBCCCBB@B?BCCBBBBB?B?@BB?BACCA?A<AA?BBBB>AAB>@@@BBC?BB?B>B=?=?>>>CC=@=?>;?A9??8?@@;;;=B=>;;;3;;:@:@@:==>B=BB:A<A<AA<@<?>>:>?;><><@@@@@@;>>@>=8>>>=;?;@<>=8<A8708;:/;>>=AACCCC;BC>CD?B?DC@CBBBBBCCBCB@BA>>?>;>@BBC>AABB?:;;::7;@EDD5??:AA=A:>>?@@A====A@@@@>>;
@MDX4E:00675:05787
CTCTGCTGAGTAGGTAAAGGAGTCTCGGTCTCCGGGACGAACTGCGCTAAGCTTAGTGCCACTAAGGCTAGAGTCCTTTTCTGTAAGCAGAAAGCGATAGCTTTCGAGTGTAATTCCCTGTCAACGACAGTTGACGACAGTGGGGATATATCTCTCAAGCTCCAGCCCAACCCATAGCCTCCGGCTAGCTCCAATCTCTCACAACCAATCAACCCAAACCAAAAGAAAAGAATGAATCTCCGATTCAAAG
+
CCCCDCCDBCCBA>BCD=B?ABBBBAA?ABBB>BB<=>>A@CDB=>>>><>?GACCBBB@CCBA?A?BBCCBB@B4:::-;@@@B=@?BBBB=BCECCCBCCC=CCCCBBBC@C?BB>BCBCB@CBBBCCC?BBABBBBBBBBB5BBBBBBB>???A8;;;A;>@>>7>:>A:AA?AA<AA=?:>=>==BDAC@CCA@ABBBE@C@C@B@@:??8?C<B?CCD9BBEF6???:;:<?@BB=<;;<?AA:A
@MDX4E:00675:05807
GGCTTCCTTCTGCTTGGTACCGAAGATCTTGTCGCCGGCGTCGCCCAGGCCCGGAATGATGTAGCCGTTCTCGTCGAGCTTCTCGTCGATCGAGGCGGTATAGATGATCACGTCCGGGTGGGCCTTGCGTACCGCCTCGATGCCCTCGGGGGCGGCGACCAGCACCATGGCGCGGATTTCCTTGCTGCCGGCCTTCTTCAGCAGGTCGATGGTGGCGACCATCGAGCACCGGTGGCGAGCATCGGGTCGATGATCAGCGAGCGGCGCTCGGCG
+
C@CC>A?B@BBCCC@C@CAB>BC?BBBAA<BBBBB?B>A>?>AAB;AA=@A<A=@>?CBBBBBBB@BB?BBCBCC?AABB?BAAABCBBB??@?;???BB@AAB899BA@????=BB>BCC>C@><B@A<AC?BB?BBBBABBB:@@BBBB3CB@BA=><??@@@=A==9>@?A<??@9@:<9ABAAC?@;@=C@AA>ABAA>A<A>798?:=<::;;=8=<9858865496;?4::===;=;;:0;;;@@>>>AA@???===:=DE@@@<@>
@MDX4E:00676:05770
GCCATAGACGATGTAGGTGTGGCCGGTGACCCAGCCGATGTCGGCGGTGCACCAGTAGACTTCGCCCGGACGGTAGTCGAAGACCCGCTCGTGGGTCAGCGAGGCGTACACCAGGTAGCCGCCGGTGGTATGCAGCACGCCCTTCGGCTTGCCGGTGGAGCCGGAGGTGTAGAGGATGAACAGCGGGTCCTCGGCGCCCATTTCCTTGGGCGCGCAAGTGCTGCCGGCAACCTTCATCAGGTCGTCGTACCAGACGTCGCGGTGCTGGTTCCACTTGATCTCGGCGCCGG
+
CC@CCCCBBBBDCBBB?CABA?B?B@BBBBB?AAA?C@@?A@:528,2855;<AB?????@<@A@@:@<@=>:=>>>B><599995<AAD@???9@AAAA?>>:=566===<@@;@A;:7;A;A<>>:>@@A@>>>@@@@@:@<@A=@@<>>:>;@@<;<:<@<<=:=>==@AD=@@@B;>>>???9?@=@>>5;;AA:AAD:A<A<@@9@AAAAA;===?>AA=D=<<9<<A<>>AA@@<@A===??A>;A:::AAA<>><<=<>><><A<AAA;@@>?A6616@A;@<
@MDX4E:00676:05780
CTGCAGCGATGCCGCGACCATTGCCTTGATTCGAGCAGCTTGTTGCTCTGCGGATTCGCCGACTTGGGTGATCTGACGGGATGCGTCGCCTGCGCGTTTACCTGTGGAGTCCAGGGATTGGCCAAGCCTGTCGACGGAGGCCTGGCCTGATCGACGGCCCCGGTCGCCCGACCTTCTGCAGCATCCGTG
+
CGCCCCEBB@@?<@B@BB;;;?BB?B@BCC@DCECAABBCACB?ACCCCC:999C?@AA@BBBC?BC>BBCCABBBA@@;@@BBCCCCE@BAAAB@@@;@C?CBCC@DCBB?@@@8@=39393:;?@=AABBCBBB?B@<@;00+06:<:::<98/)///&/6////9199:595966//-,,,,(,-,
@MDX4E:00676:05794
TCGAAAGCTCAGAAATGAATGTTCGTGAATGAACATTGATTTCTGGTCTTTGCACCAGAACTGTTCTTTAAAAATTCGGGTATGTGATAGAAGTAAGACTGAATGATCTCTTTCACTGGTGATCATTCAAGTCAAGGTAAAATTTGCGAGTTCAAGCGCGAATTTTCGGCGAATGTCGTCTTCACAGTATAACCAGATTGCTTGGGGTTATATGGTCAAGTGAAGAAGCGCATACGGTGGATGCTTGGCCAGTCAGAGGCGATGAAAGACGTGGTAGCCTGCGAA
+
>BBDD=CCD@@ABC>:::;>9=7;;ECD@CCC@BBB9BBB=5<AC?844;3?BAB?@???BBB=6>@=)7333$3396717:??>??A><<6<77/5>;==B=@@>525>@D6<AA;;6;@@>>>@<AA9==<=7:48888)6;3=@B@?@=;;5;;;;=>5:::-8807>?=CAA???@@<AAA=;;;??=@<@@AH6;:=5;;;/;=@@==@9///9==<?;==:=@>>?>>>?<>><@@;;;:>895:<///;;;38=<=DDD9====6616===9=>>>AA
@MDX4E:00677:05762
CCAATGACTGACCGCCCACCAGCCCAGGCCGCCCATCACCAGGGTGTAGGGTAGCGCCATCCAGACCATGCGGCCGTACGACAGGCGCACCAGCGGGGCGATGGAGGAGGTCAGCAGGAAGAGGAACGCCGCCTGGCCGTTGGGCGTCGCTACGCTGGGCAGGTTGGTGCCGGTATTGATCGCCACCGCCAGGGTATCGAAATGCTCGCGGCTCATGTGGCCGGCATCCAGCGCCTGTTTCACCTCGGTGATGTAGATGGTGGCGACGAATACGTTGTCGCTGATCGCCGAGAGCAGGCCGTTGGCGATGAACAGCATGCC
+
C998;CB@@A@@8:;D?DD@D@??9@A>@:89929BBBB>BFF>BAA?>?8?AA:;:=AC;5AAAC>>>><<8=6;;>>>>?@B=???<;96///@@2<:=8819A???<?BB=A=A=B;???=D=ACG@BBACCADADE?@@=@;;;DCECCCBCCC>CBC?B>B>AAC@D@CCC@CCBCBB@CC@BC?BCC>CBAAACC>BBBBBBA?<?B@>BBAA?@?C?BCCB>CCBBC@C@@A<@AC?CBA?ACECBABACCC?AA>@BBBBB>B@CCF@CBBBCBCCAA@@>?BCAA@CC@C?BB?B>AA????<BBBBBCBB?
@MDX4E:00677:05770
CGTGGAACGGCAGGGCGAGGCGCCGGTGGCCTGCCGGTCAGAGACCGGAGAAGGCCAGCCAGGCGATGATTGCGGCGTAGAGCATCCAGGTGGGATCGGTACGGCGGTCGAGCAGGGCTTTCATTTCTTCGCCTCCGCGCTCCAGAAGCCCTGGGCGTTGCGGAAGGGCTGGCGGGCCAGTTGTTCCAGGCGGGTGATGCCGTCGGCGCGCATGGCATTGATCAGGGCCGAGAAGGATTTGGCGGAGTAGCTCATGGTGTC
+
CCCD=B?BC@CBBB=BDAB>BAC=C?CB?B?BBB?B@CBBBCCBC>B>BBB?B?@?A;;7;@<@A@@@BC@DBB?BCBBCCCA???<?A>@@@;@BBBBCCDD@CC?BCD@?@CCE?CCC=BBBB>BB?BBB?BD@C>>>BB@BBC?B>?9>@@8>=<499:7:<AD:C><8667)88=:97;B<A=@@;?AA:A@@@>=6<?<<7;>>>>>AA:>>?9>@A@@>@7@:>?;;:=<@@A9A<AA<?>?<>>@AA>>:><>A
@MDX4E:00678:05770
TTTTTACACCCGTAAGATCAATCTTTCGAGGATCTAAACCATAAAGCTCTGAATGGCTTAAATCACAGCCTTGTACTCTAAACTGTTCCCAGCAGTCTTCCGAAAAAACACCACGGCTTAAATCTGATTCTTTAAATGAAGCGCCTCGAAGATTTGCACCAATCCATCTATTTTCGAACAGGTCACATTTTTCAATAAGCTGCTGCTCAAAATTGGCATAGGATAAGTTACAACCTGTTATGTATGCAGAACAAAAGTACATTTTATTCGAAACCTGATTTACAAAACTAACTTGACTAAAAT
+
5555#5955506>=:??CCC9>?=@7;<<?7?855=>4<8<;::2:<BBBBC@CE>A?299,9@=;?A<8=555=?CCCDG>CAAA=<<4<@ABBBAA?D459::::%:@B9@>A469:BC>AA@C?>:>==5=@5>AB?BBBB@CCBB?=>??8>>;?=?8@;:<@<:====143348::679:922222$2936627>;;;;<;;5555'5494;<<;;7;>>:@>9==<7<7<>>8=@BBCBBC@@;:=>DD8??@CCCDD:BB?A@?C:@:?>78829=>??4877<AA;@@=?@@@6@
@MDX4E:00678:05787
CCCTAAGCATCGGGTGTTCGAGGAAACAATCGAGGGTGCGCTCGATCACGGTGCGACCGGCAAGATCGAGATATTGCTTCGGGCGGTCGGCGCGCATGCGCGAACCCACGCCGGCGGCGGGGATCACCGTCCAGAAGGCGGGAAGGTCGGAAGTCGTCATCGGGAGAAGGGTCGTCAGCTCACTTGGCGAGCTGGTAGAGGGTTTCGCCGTCCTTGACCATGCCGAGCTCGTGCCGCGCACGCTCCTCGACGGTCTCGGTGCCTTTCTTCAGCTCGGCGACTTCGGCTCGAG
+
BC>DCACBA??CF>:;;?BBCC@CD=@@>?AAA@@<@@9;:FCDCCCECC@@A?AAA<@>@A>AABBBBBBCCC@CCDACBB<::6;BB>;;:A?@@BBDCBB?BC>BCCC@C@@@>@ADC:CBDCCACDB>AAC=?=@CC>D?B?AAA@B?AACCCEBCAAA<@A?<@@:@A@@@>>>>@@>><><BBBBBAA=@AA?>=7=?8?AB@CB@=@=BAA>ABBB?BBBBCBBBBB@DAAAB>>;AA=BCAC??;?@@??<;;;;@B9==:=>>>A@@9<///94==4-//::;
@MDX4E:00678:05796
CGCGGCGAAGTGGCCGCGGCGATGCGTGCGCTGCTCGCCGAACAGCCCATCGCGCTGGACCCGCAGCATATCGACGAGGCGGCCGAGTACCTGGTCTGGGAATTGTCCGCCGAGCGTCCCGAATTCACCTTCAGCAAATATGCCCGGCAATTGCAGGAAGGACTCAAGCTGCGCCTGCAAGGCGCGCGTCTATGGGACGACTACCGGCAGACCCTGGAGCGCCTCGACGAGCGGCCCGCCGCCCAGTGGGAACTGGCCGGCAACTGGCTGCGCGGACTATGTGGCGACGCCGAGTTCCAGCCGCTGGCGG
+
CC9979A@?CA@>@?DCC?BBCCBBAABACCBBBBBEE@CC@CCCCD>BDBCBBAA@=???9?ABBBBBBBBB:;:AA=@A?B?BBDCDC@CC@CCBBB=B@C@CAA>@A=AB@@@ABA;AB?B?BDD>A>ABBEDD8AAC@??,0,0:5:7;>AB>><><@??;>9==///::7>:>>;>;>===B;;:<<///(/:///==A>D=?BB>?>7>@;;888>=AAAABBB:::9=@-//76660:A<<=5<5;8817494::6:AA=DABBB>949>;;;<9939788AA<AA;:7;<:::==;<<3:;5
@MDX4E:00678:05803
TTTCATCTTCTGGTATCTCCCCAGGGTGGTGGCCATTACTGTGCGATCACGCCATCTTTGATGCCGAGTAGGACAGCTGCGCGATGGGCTTCGCCGCGGCGCCTTTCTTCCGGCCATTCAGAAGGTCACTGACCAGATTTTTGTTCAACCTGTGCTTGCGACTGAACTCAGCAATGGACGTGCCCTCACGGTCAAGCACCGCGCGAGCTTGCTCGGGGGTTAGCGGGGAATGCATAGTGTTCGTCCGTGTTTAATTGTGTTCGACGACAAGGATTCTTGGCCAGAAAACTGGTCAAGTCAAATGATTTTGGTCAAAAAAATTGCTCATAGCGTCCGGAACAGGCGAGCGCTGCGGGAGGAGAGAGATCGTCTGGGCATGAACCAGACGGATTTCGGTGCCTCCTTGGGGGGTAAGTCGAGGGACACAGAAAGCCTACGAGTTGGGGAGCAGTTCTCCCGACATTC
+
CC9BB@@A<?@J@BA@@;;;;*9:?,9:<?A>C6>AAAAACEAA???:::AA>AABBC?AAABB?A>?>@B?BBA@BCCCDF;;;;;0:@;?>@;?@B=?:948?69:399<8<1;;@CCCC?A>@@????A@;??99999(:A=AB@C?CCCCCF?BABBBCBC@BB@??BB?CD@CBBB@@@;@@@BB?@@@ABBBB?BC99:ABAB?BAAAAAAA2A@BBBBED9C?BB@@BC?@?@@@@@E000@@@6@1;8;AAA=CBBA??9949:?A?BB;>;B@BBBCC;CCC????<?ACCC>>??BBB6@;?9:9:9:9#88;997;@A<BBCB?C>;6;>A5;;>:@000AAAA<BC>AABAAAA==<<<688)3799</414==>>6AAA78828<;8=>4:088888%8<;@>>>>>>7>>??898>7==8@A@A??>:???2;775559>9>A9AA>A?68
@MDX4E:00679:05765
GTGTACTTGTCCACGCCGTAGCGCGCGGCCACCTGGTCGAGCAGCTTGTCGTGCTGGGCGAGCATCGCCTTGCCATCGCTGACCCGCTGCTCGTCCACCAGGCCGGCCAGGTAGTCCCACAGCGGGGTGGTGAACTCCGGCTGCGCGTCGAGCAGGTCGAGCACGCTGAGGTCGCCTGCAGGCCGCTGGTGAAGCGCTCATAACTGTCGGCGGAAATGCCCTGCGCCTGGGCCTTCTTCTGCAGGCCGGCGAGGCAGGAAGGGAAGCTCGAGGCGTCGGGTTGCGCCAGGGCCAGGGCGG
+
CCCBBBC@CAA>ACCCADAACCCB@BB@B<?>7BC=:78:9:>?BB?B?BCCA@?AA:A=>>>>=AAA:>:>C<??@@@@;;;B:B??;;;AAAA7;;=88185;4;:;;5;===BE7A@CCEDCD;EB>AAB?BBB@C?CAA:::BA@AB>>BB@DEDBBDCCCCCCDD@AA@?;>@@::5:?AA??=?AA?BBBCCAAAB?BBBC>><>?<AB:888@9==>>@=@@@9>;?;@@<@?@>;;5;5;5;=AA;>CC?B>AA;A<@BA@@??9?@A???8?=@BAB@CCD>C@BBB=BD@
@MDX4E:00679:05768
CCCCCAGCCGGACCTGGTGCTGGAGCGGGTTCTGCCGCTGGTGGAAGCGGTGGCGCGGCGTTCCGCCTACCTGGTGTTGCTGACCGAGAACCCGGCGCGCTGGAGCGCCTGCTGACCCTCTGCGCGGCCAGCCCGATGGTTGCCGAGCAGATCGCGCGGTTCCCGATCCTGCTCGACGAACTGCTCAACGAGGGGCGCCTGTTCCGTCCTCCACAGGCCGCCGAGCTGGCCGCCGAGCTGCGCGAACGGCTGATGCGGATTCCCGAGGACGACCTCGAGCAGCAGATGGAGACCCTTCGTCACTTCAAGCTGGCC
+
AAA>,=00)/5772/;2;:BCA>@?987.939989<AA=>98:29=?<A=9979A=A=AAB;>:8636BB@CC?B8979A@@9839@993::,98=///9;=79>>;;7;@B>A;;;6;?>>=<66*/(/9::2:?>?:>;??<??@CCCCBBB@@@@9>8>A=BBBB?BBBBBBBA?:7;>>>?@>:886888(8<<:@AB<@<???=AA<@@>><>=AA<?<<==B@B@CC@DAAABBBCDAC>9949>><@@@A=??<>@8??>9>BB@@=@CCBCBBCDCCBCB?BB???:?@CBCBBBB?@@>A?:;6;?
@MDX4E:00679:05779
CAAACGTTTGCGTTAGGTGAATATGCGTCGATCTGACAGATTCTGTCAATCGCCATGAGCAACTGTCGCGAACCGGTCGGGATCGGTTGGATTCTAGTTCGCTACGGCTGGGAAACGCAGGATATTTTGCTTGGCCGGCAGATCTCCCGCCGGCCGCTCAGCGCAACCGGTGCTTGTGCAACAGGCGGTAGAAGGTCGGCCGCGACACCCCGAGCATCCGCGCGGCCACGCTGAGGTTGTCGCCGTAACGGGCCAGCGCGTCGCACATCGCCTGGCGCTCGGCGCAGAGCTTGTAGACCTCCAGGCTGG
+
ACK?DGDD>EBBB?BB@CCC=BBBBBBBBBB=>8@@B?C@@<???@>>:@AAA:>>@@?@B<?==>>A===;A9>:>>>>7>AAA:=:<8<>9>>A>>:=>>??=<8;99929=3=>@@@<A???AA3@@B=@<@<><>>>BCCAAA:??;>;><>?AD???CDC=A<A<AAAA:==@@@=A>>:>@<@B@@:@:@@>9<:=<<;;7777,8==>A@?=?CC??<??CBBBDBBB?B?CCDAA>AA?:??@:?<BCDAAABBCCCAAAAAA<AA;?>>BBC??A;BB@B=A:??>@@C;@@:==9=AA9
@MDX4E:00679:05785
CACCAAAGAGTTGCTCCTGGTTCGGACTGCTGGGGCTCACGGTGAAGACCGCTTTCACCTTGTCCTTGGCGGTGAAGGATTCGAGCTTGCCGTAGACCGTGTCGCGGTCGCCGCCGGCAATGGTGTGAACCGCGACGGTGGCGGCATTCCGTACCTGGCGCTCCAGGCGGTC
+
CAB>BC>CBBB?BBBB>BB?B=A@?BBBBCAAAA8ABBBBB?BBB?BBB?>>AA:???=D:>>@<@<@;<<;>=;9<69>;?@?=AC?B@>B>=;>>9>;;;AA;;7;>>>;AA:@:@@:??;AAAAA7=9=>>>?A;@@;>>:>>>;@:>>AA:@A=C>>>A=8868>;>B
@MDX4E:00679:05787
GGTATGGCTCGTCCATTGGACCTTACCGCCTCACACAGAGCATACGTGAGTTCGGAATTCCCGATCTTAAACTCTTCTGGTTTTTCCGGACGATTGACCCCGGCAAGATGAAAAATAAAATCGACGGAACGAATTAGCTCAGGCAAATTACCAA
+
C@CCCC?BCDCCC@?>:>>@B@CACD>CB?CCCBCBDBAAABBCBCBBCCC@CC@B@C?BB<A@@@@<@B=CCCD@B@@?CCCC1759@CCBBA<A>A==+939=5999;6677)55>>.@AAA?@<A;>>=:><@>?AA9:7:??8@=AA<AD
@MDX4E:00679:05795
CGACCATTCCCCCCGCCTGGCAAGCAGCCGTTGATCTAACATCCAGTGGCAGTATCCCCCCTGGGGGGATATGATTTCAGCATGGAAGACATGCATAAGCACACCACCCATCCCGACCTGGTGAAGCGGCTCAAGCGCGCCGAGGGGCATCTGCGGCACGTCATCGGGATGATCGAAGGGGGAGAAACCTGCCTCGACATCGCCCGCCAGCTCGCGGCGG
+
EEDD@B@499999$;B=BD@BA<@?@@@?BB@BBBCCC@CBBB?CCCC@CCCCCCBBCBB)BCCCCC(CCCCBBAA<ABBBBBC=@=@BBB@?BBBB>A@@AAA;???7>>>>7>;;7;?;@??9<;;59>>>5;;?>>@=A>===3>@CABBBC@BCCCCCCCCCC>CCCBBBCD?AAAA1ABBC<B>ABC?BAABBBB<<<>7>A:>>>CCB@@=999
@MDX4E:00679:05800
TTCCTGCTTTTGATAGGGCCTCTAGCATGTTGCTTGGATTTAGAAGGCGTCCGTCGAAATCAAGGATAAGCTTCATCTCAATGCTCCGCTGTGACCTAACGTTAAAGTCTTGGTGTGAGTACTTCCTAGGCTGAATGAGTTGGCTACAAATCTCTTTGCCTTATGTCAATATCAGGCATTCGCTGTGACCAATATCATTTTTTGAGTCATTTTTTACAGCTAGCTATCTGCTCCTTCAGTTTTCTGTCGTCCACGTACCGCTGCATGATCGACAGCACCAGACTGTTGATGGCGAGGATCTTCA
+
:6;?CCBBBB;BDCCDD=A>ABBCECBBAA>@BA>B?BCC<?@B<?;?B@B9::CCCF=CCC@D@BBB>ABE@BBBBCCCABBACCACCBBABBB@BD@CBA>AD@DDAA>A?AABBBBBBCB?C@BBB>BCBB?ABBAA?A@CDC@@@;@BBBBB;AA=B=AABBBB?ABCB@A?ACCACBBBBABAD?B?BBACABBBBB)BBBAB;;;;;;%;BAAACBBAA@@@@@@@B>B>B@@@BB9BBBBBBCBACBBBCC@CCBBBAAAA???BABBBDD?BBCC;;;<@@@@;>>>>9==?B7;;
@MDX4E:00680:05789
TGAAATACCACCCTGGCATGCTTGAGGTTCTAACTCTGGTCCGTAATCCGGATCGAGGACAGTGTATGGTGGGCAGTTTGACTGGGGCGGTCTCCTCCTAAAGAGTAACGGAGGAGTACGAAGGTGCGCTCAGACCGGTCGGAAATCGGTCGTAGAGTATAAAAGGCAAAAGCGCGCTTGCTGCGAGACAGACACGTCGAGCAGGTACGAAAGTAGGTCTTAGTGATCCGGTGGTTCTGTATGGAAGGGGCCATCGCTCAACGGATAAAAGGTACTCCGGGGATAACAGGCTGATACCGCCCAAGAGTTCATACGACGGCGTG
+
7@B>6@@D5:5625B8D<@@;;:==<9=4733,336664:;///7266394;858@@:?A@=>B@@?@<>==6<99=?7<<=<<;;,77/5;22,292555-555;;6;>3662222255527,..66.....880818:?;??75557;799A977555555&247<;;.:58;@@?;@>>?>?<<>AA?DD;8899=>::9937...53-333A=A>=:>AAA>;:055::27376?A;=<7</555*55999=733305734....&.(.878=1///)/78378949=@@@>><>??:?;??BB=B???@B>??<?@@@
@MDX4E:00681:05766
CGATGGCCGGGTTCAGCGAGTCGCCGACGTCATGCAGGATGTCGGTGCGCAGCATGCGGTATTCGCCGGTGAGGGTATCGACTACCACCTCCGAGCAGGCGGCGCCGTAGGCGAAATAGTAGAAGGGCCGGCCACGGGCCTGCTCGCGGTCGTAGAAGATCTTCGGCGTGCGGTAGAAGCCGGTGCTGGACAACGAGACCTGGCCGAAGTAGGCCTGCTGGATCAGTTCCTCGAACGGCAGGATCAGCTCGCG
+
CCBBC?C?BB=B@CCBCB@??@@?<ACBDDCBBBBBB>BBBBBB>@@;A???@AA>==7=AA;@@@;A:<;=@@7@>?>C>>>=>9>>:>@;@>>>>>9;;9;??:?A@>9<6994:BABBBB?BB=A?BAF@DCCC=C@CCCCCCBB>BAAABBC?BBBBC>A@===<<<B=BB@A?AA:<8>??@B<@?>:>A>>=@;@>9><>?;>>AA>A@CCCCC@CCCBCC?C?CCCD@AA>ACD@CCAACCCCCCB
@MDX4E:00682:05765
GGCCATATCTGCCGGCAAATCAGACAGCGGCAAGCCGCCAGGGTGACGCGTTCCAGCCATCCCTCTACTATCGGGGCACCGTGATCAAGAGGATGTCCTGATGTACCTGTGGCTCAAAGCCTTCCATATCATCGCCGTGCTGCT
+
E<B?BCCC>5;6497555)44::=@548?9>=48=:@@=99929>@>?<8937278@.25AA5=;7?=;887777&833399:338=9;;;9?>><=:@@ABAAAC=<<00+000<;3=<*0*0*//:98:---5(-----:96
@MDX4E:00682:05807
GAAATCAGAGGCACAGACAGGTTTTCCTAGGAATGGTTTCCACATTCTGTAGGAATTTCGGAGAGATTTCGACGGAATAATGGCGTTTTGCTGGCGAGTGGCCGAGGCGCTCGTCGGAAAGCTGGCGCTCCGCTAGCGGAGCGCCGCCATGGTTCAACTGAAGGCGTTGATGAACCAGGTGATCGCCGGGATGGCGACGAGATCGATCAGTACCGCGCCGCACAGGGGCACGATGATGAAGGCCTTGTGCGAGAACACCCGATAGTGCTCGCAGACCGCGCCCATGTTGGCCACCGCGTTGGGCGTGG
+
CCC>CCCAAA?CDCAABAAC?CAA9C>BB@=?=BB?BC>B?CCCB?BBBBBB?B?BB<AB?BBBBCCC>BBBBB?A?AC?CD9@9999-9@?@>BAAAAA>A@B@@=@799BECCC?CE@CBBA?ACBBB?CCABACC@BBB>><>B?ABB?B?BB?ACBC>><>BB?@AA@@=B?BC?BBBCCCC?CC>CB><BBBBBBBBBCBBA@@CCCD?C>>><AAAAAAAA5AAA>>>CC@@@>A>A?B@CCAA@AAB>A?>?7>A>>>@@;;<A@@=>><@;<<<7<?AA;>;><@A<>>>@=AA:AA@@<
@MDX4E:00683:05780
CGCCGCTGTGCAGCTCGGCGGTGAGCAGCGCCTCGCGCTCCTTGGCGTCGAACGGGTGGCCGCTGTCCTGCACGGCGATGCGCAGGCGCGGTGTCTCGCCCTGGTCGTCGAGGGCCACCACCAGCAGGATCTCGCCTTCCTCGGTCTGCTTGAACGCGTTGTCCAGCAGGCTCAGGACCACCTGGCGCAGGCGCGTCGGATCGCCGCCGATGACCCTCGGCACCTGCGGTTGGGGTGAAGCTGATCAGCTCGATGCGCTGCTGCTCGGCCTTGACCCGGAAG
+
C::9;CCCCCDDCBBBD=9979>>BCBBBCC@CBBACCCC@A=@==000@:6.00*/;(/+/:<=AB@DABBBB@B>>>BBBA=<8<<<<8=AAAA@=<<5AB>BCCDCCCBE<A=@@<@A>AABBC@BBBCDBB>B<>;>AC;<>>B>?;BB@AAABB@CAC?>>>??<A?9994:<6<>:8738@@?@<>>>>>>>;>D===7;;5;>>>;;;3;>>:===8:;9;)/)/99-88;27::A@A<=<AA<=<A>@@AA???AAA@@<@:><??AA:B<A:=
@MDX4E:00684:05772
CCCTGCTTGACCTGAATCAACGGCCAGGTCCTCGCGGGTTTATGCCCATCGACTTTCTCGATATTCCGATTTCATCCGTACTCGCCATCCCTCGCTGTCGCCTCGCTGGACTGCTGATACCCGGCTTTCCTGGGGAAACAGGACATCCATCACATCAGTCGATAGGAATCACCGGTTATTTCCCATTGATCTCATCGAGGCCGTCGCTAATATCGAATCCAACTTCCAAACAAGGAGCCTCACGATGTCTGACGCATTCCTCTCCTCCATCAAGAACCGCCGCACCATCTACGCCCTGGACAAGCAACTG
+
CC?CBBD@BBC?BBB@A=@<BB?A?@@<?B?AA???@5>=5=>::929>>><576(27:=AA:;8;;>>@F:>>>><@@ABA@@?9@;;:.;@AA@@@@@B?B;<;CC@DC=<=GDCCCIH@H@CBC=B?AAIM<CB>CBB@BCCCD@CDCAAA@AA;;;@A@BB>B6;;CB>B@C?@@B;@C=CC@CCCCBBBB@@00+05;;=>@@A?B>???C;>>:B?BB<;6;?9>><><@>>;>@@@??888==>????CC=C=???@:=>=CC;;8;B:>;;;5;@<<7:///=?DED:??=>>><@@@<AAA
@MDX4E:00685:05766
GTGCTTTCGGCGAGAAGCCCCCAGCAGAGGAAGTCCTGCTTGAGTGGCTACAGGAGCCCCTCGCGATCGACGGACGCCAGGTCCGGTACCGATTTGCCAAGCAGAAGGCGCGTTATCTCAGCGCCGCGCTTCAGAAGCTTTCTGCTGAACGACCGCCTCTTTCCTCAGGAAAGGAACTTCGTGACTGGCTGCTGGATATCCCCGG
+
CBCCD@6BB:BCCCB?CADDD1BABBBBA=@>BBB>BBBB>BBB>A:8>>CBB@=:8AA5AABACA>>>>@A=A>?=:>@<??:>9<A@9>>>>9>A=A4<<AAA<?<;=;>=;?AA@@@@>??8<888=;AAAA5::@A:>>=AA<<9<>>><??=BAAA9><>@@@<@B9>;?=A?;>>>>>A>>:>AA>>>9>==;AAA2>:
@MDX4E:00685:05781
GCGGCGATCGCCGGCGACATGGCGGCCAGCCTGTACGACCTGAGCAAGCTGCACGAGAAGATCGAGGACCGCCCGGACAACTCCACGCGCTTCCTGATCATCGGCAACCAGGAGGTTCCGCCGACCGGCGACGACAAGACCTCGATCATCGTTTCCATGCGCAACAAGCCGGGAGCCCTGCACGAGCTGCTGGTACCGTTCCACAACAACGGTATCGACCTGACCCGCATCGAAACCCGCCCGTCGCGCAGCGGCAAATGGACCTACGTGTTCTTCATCGATTTCGTCGGCCACCATAAAGAACCGCTGATCAAG
+
CCC?BCBBBCC@D?ABBBBBB>BC:=:>BB?BBBBBBBB@B>??BB?B>>>CBBBCBB?BA@AAA@=;?<?BB;@=@?<9???9;@??@@A;>:>>AA>>????AB?A7;;;>>=A=A<@?<?@@=A:>;;;@A@@<@@@<@>>>@>==@>>>9>=A@@@@@@9==9>>5::/@@@@;@BBCBABABCBBBC@CCC@@@<@>>00+00+0@<@BBBCCC?BBBCD>BAACCCCC>CD<@@@:@@A==?AAA@>=;;;3;=9=>9==@@BBC<>>:>>?>?;;;1;;::=7=1889>===8=B<@=DGBCCBBB?9
@MDX4E:00685:05789
GTCAATAAGGCGGGGCGTTTTCTACTCCGGTATATCCATGGGCAGCAACTATCTTTTGCCTCTTGCTGCGATTCCTTTTCTCACGAGAACATTGTCAAGCGAAGCGTTTGGCCAATTGGTGATTGCCCAGGCCGTGGCTGTCATTCTATGTCAACTGGTAGACTTTGGATTTATTCTGGCAGGATCAAGAAAGGCTGCCATTATCGATAACAAAGTTGAACTGTCTAGTT
+
CBCC<B>9A465>;+:3777&3:>?AC?B?AABBBB>BBAA<B???B?BCBBBBBB8BB>BCB?CCABBBBB@B?BCC:CBCB@@@BB?BCC>B@B>:>><=8<>>>>7?;>=D;@:@<;;<A<AAD;>=9>9>>>9>??=?;==AA>>>@8849=A;A>>>AAC:A<@@@7@A;A=<8<8828>>>:>AC6=8<>??;??9>>A??;;5;<;3;?9==:=;>:::@@@<
@MDX4E:00685:05801
ATGCAGCTTGCCCCAGTGCGGACGCCCGGCGTATTTCCAGAAGATCGGTTCCACCGCGGCGAAGAAGTTGTGGTGGTCCATGTTGTAGTGCTGATGCACGGAAATGGAACAACTGTCGCGGCCCTCGAACATACTCAGGGGAATGTCGTCGGCCTTCACGTAGCGGTACTCGATGGGAAACCAGGTGCGCAGGTCCTTGTCGCGGATCAGCGCGAGGATTTCCCGCAGGCAGGCGGGGCCATGCTCGGCGGGGACCGAATAC
+
CEGBA@>@;@??@7@ACA??<@??>?8?>@BBCCC>C?CBB@>>>>?:><><?@=A>>:>>C=@@;@A;>@A<AA;@>;@;;;=A><<?>>?>AA@>>>D>BB>BCAD?EB@CBCCCC>>;?>5>A@B?BBCAAA@DCCC6><?BBBBBDC@B?B@BCBBBBBBB?>ABCBAA@@@9BC=@<:;7;;>AB7868B<A=>>>@@@:?>>@A?<<<>>=BBD7=<1;=7717BB<AACD5@;???AAAA<????3>@;@?<>>@
@MDX4E:00686:05775
CTGCAATTTTCGCTTTATTGTTTCCGTCACCTGCCCTGTCTGTGGCGACCTAACAATTGCGTAACGCGGATCATTTGAAGCCATGTAATAACAATTGCCTTGATCGGAGAGAAACAAATACATATCGTCCTCTTCTATCAACAGACCGGGATGACTGACTTCTAATTGAGCACGAAATTTTTCCCGCCGTCTCCTCATCATCGGACTACGTGCAAGCGTGACCAATTCTTCAGCAAGTTGCTTTGGAACATACAGAACTTGAGTTTTGTCAAATTTCGTATCAATGCC
+
<ABBC@BCC9BBBBB=BC?BBD>D=@@BCC?B99969@@@@@?@<AB@C?CB>AA>B>BBCB?;??888=BBBBB=B=9==<??AAA:@A:??<A7>;<@<@A?@@9=?>AAB:AAB9@>@B?A>>>>><???<AAAA@@8;;@@A=AB:AAA@@@@@@B=@@@<A;>>>>=>?A=(6666(8@4>?7;;@@D7;8>B@@@?B9@@>>??>AAD=A=====D<A:A<AB=@A:;;5<=:?>>?7=:=<??@??@@@<<<6<>>===1=?===3::3:BBAAAA<@@>9
@MDX4E:00686:05776
CGGCGAAGGCAGGGTTCTCGGAGAGGAAACCGTAGCCGGGATGGATCGAGTCGGCACCGGTTTCCCGCGCCGCCATGAGAATCGCCTCGATATCCAGGTAGCTCCGCTCGGCCCGCGCAGGGCCGATCAGACGTACCTCATCGGCCAGCCGCGCGGCCAGCGAATCGCGATCCGCCTCGCTGCACACCGCTACCGTGGGAATGCCCAGTGCCTGCGCGGCGCGGATGATGCGCACGGCGATCTCGCCGCGATTGGCCACCAGCAGCTTGTTCAG
+
CD@DDD?A>@B@@<B>@@BC?BACC>BB<B>BBBBB>BB5AAA>BAAA>>9<=5CCC7>4@:3??7?@>>;;;7>@@>><<@@A@:@@>>>CAA:==9=>>>AA9>>?>>:>@7????<<<6<;A>>>>>>@<<<?;??@AAA:>:>@>9=?@;;7;=@A?>?=D>><?AAA9>>=AAAA??>@@@B<@@?==:=AAA9A<@?@B:A===A<AAAA=<8<>><:=AA;=<A>=>>=9>@A>>>@==9>A==<:>:>8==9>>>>???:>>:>==
@MDX4E:00686:05779
CTATTTGCCCAGCATCCAGTTCATCGAGAACAACCCCAGCAGAGTCATCAGCAACGAGCCGCTGACGTGCGTCGCGATGGCCCCGGCGGCCCAGCCCAGGCGGCCCTCCTGAAGCAGGCTGACGACCTCGGCGGAAAAGGTGGAGAAAGTGGTCAGGCCGCCGCAGAACCCGGTGATGATCAGTAGCCGCCATTCCGGAGCGATGCCCGG
+
CCCCC>CCC=BBCCCC?@AA?CCBBBBBB>BB?BBB:BBCCCCCBBBBBCBBB?CCCBC?CCCCCCCCCCCCBBC?@@@4:::-;@AA5;;0;@@?8?@9;;49:/:?;@BB?BBBC@CBBCCBBB=BAA;>><BBB9C@DD?CA@?:?@@=ABBB>B?BB?BBBBB>BB;B>B@@@ABBBA??CCC@CC@CC@C@C?BBCDDC???:?;
@MDX4E:00686:05786
CACCCGCCCAGTTCTGCGCGACCCGTATCCAGCAGGTACTGAATTCATCGTGACGTCCCTCGCGATCCCAGGGGAACTGGACTTTCACCCGTCCCCACTCGTCGCAATGGATCTCTTCCCCTGCCGGGCCGACTACCGTCGCAATCTGCGGACCATCGATAC
+
A;;9)5990?CCACECCCBBCBB=BB@A@?BAACC?CBCBBB?B?BBCCCECCCC99:7;BAA??;;;0:??A6B@CCC@BBBH>CBBB;BAAA@7AB@A@AABCB@AA>BBCCCC?CDE;BBC?BB<BACBCCBB@BCBBBB?BBCCAA?AA<ACCCCCCB
@MDX4E:00687:05793
CAAGTGCAAGCTGATCGCCGAACCCTGGGATTGCGGCCCCGGCGGCTACCAGGTAGGCGGCTTCCCGCCCGGCTGGGCGGAATGGAACGACCGTTTCCGCGATTGCGTGCGTGCCTACTGGCGCGGCGACGACGGCATGCTGCCGGAACTGGCGCGACGCCTAACCGCCTCCGGCGATCTCTACGACCAGCGTGGACGGCGGCCCTACGCGTCGGTGAACTTCGTCACCGCCCACGACGGTTTCACCCTGCGCGACGTGGTTTCCTACGATCACAAGCACAACGAGGCCAACGGCGAGAACAACGCCGACGGCAGCGACCACAACCTGTCCTGGAACCAC
+
00+/:=;A?@CBBBCAAA>AB?BB=BBB=BE?BBB???>0=900,00@@=BB?AED@AB>AA>AB=BBD>C?BBBB=BC?B?BB?A?@@?C@CCD>C?CBABC?B@@?DB:98A8>999A=A>;:5:<<=>887<??A@@???:?;=367C=???A>>>@;>A6:6:@<@@=A>AAC??@AA???AB<A@;:;;8=<<78818?6BBBBBCB>><?>=:>D668AA@@7;;@9?@>:::8<<3:;??9?BB;;;;:::>088-85;@===???==9=;:;A<BB;;8;>G<?A?BBBBB?B@<@B?9=@9948?<<<<;499<6<;<:;;<@@=@<@<@?
@MDX4E:00687:05799
CTGCAGCGAGTAACAAATACCATTCTTCCATTTATAAATTTATCCCCAAAAATACTCTCACCCCTTCAACAGGGTTCTATTCGATTGTTCTGCGTGGTACGCCATGCTAGTAGCAAAGCGCCTGCAGATAATCA
+
CCCBBCCCCDBA>ABB=BCFACC@BB=A;;99)5=990:<2;:>@@7@A@A0@?@@?>?;;>>(0*0>:9<<A1848@>>9:://(.323339::?<>>>==:=>>AAB===>999/96..(.--4---549..
@MDX4E:00687:05804
CGAACAGGTACCGGACCTGCTCGACGCCGCCAACAGCGTGGCCCGCGAAGCCGGCATCGAGGAACGGATCAAGCCGGTGCTGAAGGTCGCCGAGCAGTTCTTCCTCACCCCGCCGGCGTTGCTCGCCGGCCACGACGGCCTCGACGCCCTGCTCGACGAAGCCTACCTGGCGCACCGCCTGGTGGAAGAAGTGAACGACCGCTACATCGCCCACTTCGGCCAGGCACTGATCCCACTGGACACCACCGTAGCCAACCTGGTGGCCCACCAGTTGATCGGCGAGCCCTTCGCCAACCGGCTGGACGAAGCCGTCCACCAT
+
BBB@CCC?BBB@B@CC@BBABBBBBBB>@@<@@BBBBB==:<C8@@@@<@@<A<?:::A@@9@<@A;>>>?:?C?C?BAABCCAG?B@??<=>?@@@A?BB?C@CB????2@@=@=?@@;??@>=:5;5:*00;;?A??<;;:>==AC7==@AAA>>>B<@@;>>A<>>;>??<=:=@<@@:>><@<@@<@ABA;@@AA;??@AA<<<>>>7>;;7;<5;;<=8<@AA@@?@@9@AAB<@@8859<6;>:996:<=7;;66616;19939::5::;;<;??@@AA7=:=??:?<?<A;>@>9>>>>9>>9>@@;>>7;;
@MDX4E:00688:05762
TGATCCACATCCCGGGGCAGATCCTCGCCGGCGCGCGCGACATGATCGCCGGGGTGATGCGCAGCAAGACCGGCATGGGCGGC
+
@BBBC?@@@999,;AA3@B=ABB?AABB=@?@@@@ABBBBBBCFCDDAA=AAA7BBBACCCBBBA@>?@C>C>BCBDD=CC@B
@MDX4E:00688:05795
GGAGATCTGGGGCGGCCCGCCCGGTTCGCCGGAAGAGGACGGCGACCGCTACATCGAGATCTGGAACAACGTGTTCATGCAGTTCAACCGCACCGCGGACGGCGTCATGCACCCGCTGCCGGCGCCGAGCGTGGACACCGGCATGGGCCTGGAGCGCGTCAGCGCGGTACTCCAGCACGTGCACTCGAACTATGAGATCGACCTGTTCCAGAACCTGCTGAAAGCCTCCGCCGAGGCCATCGGCTGCGCCAACGACGACGCGCCGTCGCTGAAGGTGGTAGCCGACCACATCCGTTCCTGCAGCTTCCTGATCG
+
006BB@@@ADD0AA5;;094;2?7?7:<@6:79=B>C?BCC@C9:98:9@ABABB@@@>@@@A>A?DB@DCCAB>AA;;;CCD7;;>B=BB@@=@BB@CCGBFDDCB@@@;;;0;>000+05>00+4:99>=B?=B=B@D@BBBCE=B?@@=@@@@@??AAABABB@CDCBB?AAAAABA@CBB@@;;7<ABBCBBCB;:9B?@??;?=????A?>AAA@CD=BB@881;;5:::4:9<<<A=A=@@;;7;@B@@?@@::9>?:?@@@@>==9>;@A=AC7969:?:>=BBB?BA;>877738;<8=<@A@ACB
@MDX4E:00689:05761
GACGAAGACGCCGAACTGAAAGCGCACTTCGCACCGCTGGCCAAGGCCCTGACCGAGCAGGAAGCGACCATCGTCGCCGAACTCAATGCGGTCCAGGGCAAGCCGGCCGAGATCGGCGGCTACTATCGCTCCAACCCGGAGCTGACCAGCAAGGTGATGCGCCCCAGCGCCACCTTCAACGCAGCGATCGACAGCCTGGCCTGATGGCGTCACGCTGACGAAGCAGAAACCCCCGGGCCTAGCTCGGGGTTTCTTTTAC
+
CCCBA>BBCA?<?B>AAAAB<CCCCBBC7BBACD@AAAA?D?B?B?CB?BBBB@@?;@>;8>0:;>>>;???>????=??;889B=B?>><?@;>>>9;;5;D;><>=>AA@@>>88939AA@AABBBBBA>A?BF:A588;?@=A7;;@@<@=@??>=<:999-9=<<>8;;=B=DC:@@@A?>>??AC???@A=BB<B7;;>AA<>>>@BABA@@@AAA<A???AA09:9:.:A7A:>:::=8895&29.2222&28
@MDX4E:00689:05790
CTTCGGTCGGGTCCTGCGCGACCGTCGCCAGGCCTTCGACGGTCGTTGGATCAATGTCGACAACAGTTACGACGCGCTGGGCCGGCAGCGTTCGACTACCGAGCCTTACATCGAGGCGGCGACCGTCCTGCAGACCACCTGGGACGCCCAGGACCGGCCGTTGGCCCGGCAGTTGCCCAGTGGGGCGCAACTGAGCTACAGCTACGGCGCGCGCGCTGCTGGTGGCAGTTGGAAGCAATATAGCCTCGGCTACGACGGAAGGAGCCTGACCGAGCGCCGCGAATACGATGCGCGTGGCAAGCTGGTGCTCAGTACCAATGCCCTGG
+
CC@CC@CDDE=AB?BBCBB?@??BBA>>;@B?B?B?CBCBB?@@@?=@?BBCF>AABBCABB?====<AA::8>>;<555,57=:>>>?AA<A??>@@A;?===9>9>A>>>A;:59:5:===6;;@<??B;;;B:>=<AAA:AA??A5==;@D=D;>9>A=A;AA8A<AAAB;>=>5;;;@@@6>>>D>B@@???@@@@@@@?@A;A;;:AAABCBAA??<@><===>9><@:>>A<AA???A;AAA<AAAAA>>><A=D;@>>;;===7<6668@5=?AA=A<>>>AAA@==?@=>@<@@@A<???AA>>====@=A99929=1
@MDX4E:00689:05796
TCGACCTTGACATGGTGTCAAGGTCAATCCTCGAAATATCCGGTAACCGACAAAGCGTCAAGAACGGGTAAAGGCGGGGTAAAGAGGCTTAAACCCTACAAAGCACATGGTTAACATGTTCACCTTGTTCTTCACGAGGTAGAACCATGTCCATCCGCCGCTATTCCCCGTCACAGATCGCCCTGCACTGGCTCAGCGCCGTCGCGGTCCTGCTGATCATCGCCCTGCCCTACGGCGCCG
+
>BA;;498=AAABCACCCCD@B?BCC@CB@BBBBB=BBBB?B=???A?@B99829@@@::98C?CCC;BBD>A;;;;;5<AD:@;;:=969;1991/////(-47...55;)/,;9ACJ@BAC7;6;;>AB>BBAB;;9;CCB?C????AD>AAB>@@=?99:A>ACC9@?AB?????B@@C;;;;AD66*//99>===8=<>:7818818=>>?>>>???;;:/@;;;0:A@@:<00+0
@MDX4E:00689:05799
CTGTTCGCCGGCAAGCTGGCCGACCCGCGCGACGTGGTGGTGGGCGAGCCGGAACTGGGCCTCGGCCCGCTGCACACCACCTTCGATGGCCGAGGCAACGCCTACACCACGCTGTTCATCGACAGCCAGTTGGTGAAGTGGAACCTGGCCGACGCGGTGCGCGCCTACAAGGGCGAGAAGGTCGACTACATCCGCCAGAAACTCGACGTGCAGTACCAGCCGGGGCACAACCACGCCACCCTGTGCGAGACCAGCGAAGCCGACGGCAAGTGGATCGTGGTGCTCAGCAAGTTCTCC
+
BBCCACBA?A@AB@BBBB@C?CCBC=B@ABBBABB@>BC@??@9=?===:>=B=???@9@>AAA;>>9>BBBBBBBB?BB?C?BBBBB;?;?BB@BF@BBB?A@@@@=@@@@@@@?ABBBBBBBBB?>AA<?:??C?BCC?B@B?CB?B?BBBCBB>BB@@@AB?AA??9=>7=><>A7949C999BBA?>?<AA<AACC7??AAA@@@>>A><<A;ABB7;99-;;994:<>>7757@A:DCCCBBCDDD?ABBBB?AA@CCBB@BC@BCC?CAA@AA=AB@BBBBAC?AB=B::7
@MDX4E:00690:05767
TGGAGTTCTTCGAGGCCGGCGGACAGCGGGTGAGCCTCTGGTCCGAGGTGGAGCACGAGTTTCGCTGAGGCGGCAGTGGCTGAACTGCAAGCCGAATGAAAAAGCCGGAAGCGCGAGCGCTTCCGGCTTTTTCGTCGAGCGGCGAGGGATCAGTTGGGGCTGTAGATCTGGTCGAATACGCCGCCGTCGATGAAGTGGGTCTTCTGCACGCTGCGCCAGTCGCCGAAGGTCTTCTCCACCGAGAAGAAGTCGACTTTCGGGAAGCGGTCGGCGAACTTGGCGAGGATCTCCGGGTTGCGCGGGCGCAGGTAGTTGTTGG
+
ACACBB?BC@BBCC@C@E@BA>CCBBCCC=CB@??;@A@A=?@>ABC?CB@BB???BBCDD:ABBBB??;7718@A@A?BBBC?BBBBB>BB?=<7>>AAAB3BC@C@B?BBCBB=>BCBB?B?B?BCCCC3A@=A@>=AB>BBBBB>BBBBBB?BBB5BBCCBBB@@AB?BCBB?BBC?<655/7788=;<=7;;>A9>==:>??AA>>>@AA><8<C>>>@;>>9?<@@@9<=A=@@;?AAB<BB;??A@@@AA6?>C;D=?;;68//*/96236177=@BB=???@@<@@:@<AAA==;6;<@A@;@A>>9>>:=:
@MDX4E:00690:05790
CTCAACGACGTCGCTCTCATCTGGACTAAGCCTCTTGTCTTGTTTTATATATGAAACATCGTTTTAAATATAAAACTTGCAGAAGCCATGCCAGATGAAAGTTCACCGGCGAAACAGCCTTGTTTCGAGTATTAAACTTTTAAAATCAGAGAGTTGAATTAAAGCGCGGAGAATTACCGAGGAATCCTGCGACGAAAGGCGCTCCGAGCGGTTTTCAACGCGGTTCCGCCAGGCTTTCCGGGAAGTGGGGCGTTTGTTGCACACGACAAGGGAGCAACATTGCTCCATTCGGTAACAGGGGAAGTTTCCTGACAGCCAC
+
<@@@:>:=@:::AAAAABBBBBB?BBBB?AB@A@@=@CCC?AAJI<BBBA;00==5=000=>>>0>@7=ABBDG9ED>?999B?BC@BBBB?BABBBBB=BC?CAE=A000>@788=?:=7;;;1:;<=>AA>AD=AAAA6@@A8ABBBBCA??;?B=A5;;1877::4:A?;;48839//*.27739>>777555'2177932,22666/555*55/5658(/(/(.5/:<:;=>2<9<>9>;D:::8-8777(6>4;6>>////78(//(/77>;;;76;;;;8:>79728?9;=BAA2>685@0>7<:88@@D==6
@MDX4E:00691:05804
CGACATGTGGATTACCGCCATGCTGGTGGGCTACACCTCCGGCGCGACCATCGTCTACCTGATCCCGGTCGGCCTGACCATGCTAGAGCGCAAGGACCACAAGTACCTGGCGCTGGGGGCGATGGCCGGGTTGATCAGCATTCCGTTCGCGGTGCTGGCGGCGTTGCTGCTGATTACCCTCAACCACATCCCGGTGCGCGAACTGGT
+
CCCCBBBBA?AC?BC?CC?BBCCCB?BBB<BBBCDD@CC?C?CBBBBA>BBCAA@@AA6A?@BBF;=<=A?;@;>?@@====?>>>>==>>A:>:>>7=;?9<=<=<6616<<<?EDD.;:::=8<6<=6=<ABA@@>;:?=@@B@=AAA?;?CB@@=@@<ABC>BBDCCGBBB?BB@:@>>:?<?CDDCE<><>??>@@?>BA@<@
@MDX4E:00692:05763
CGCTGTCCATCGAGGTCAGTCCGCGCAATACCGCGGCGAAGAGCGTCAGGCAATGGCTGGTGCCGGTGGACAAGAAGCGCAAGGCCGAGCTGTTCTGCCACCTGTTGCAGGCCAATCGCTGGCGCCAGGCGCTGGTCTTCGCCAAGACCCGCAAGAGCGTCGAGGAACTGGTCGGAACTGTTG
+
AAA@@;;.5==;<=<?@BBA@<AA@;;4999.495.555.59599;:?><@A=@<<@77-34?:>299:>>A:>>9>:54949=A=BDA@@:;7;@@@=;;6:BA<A:9929.424;3///)///49958::99.3/83/..(.(.547.-..(.73338777727587;5538060,,,,(,
@MDX4E:00692:05776
CCTGTGGAAAAGCCTTGGGTGAAACCCTGAAGCCCAGGCGCCGCGAGGCTTGGAGGTCGTAGCGCGTTTTTTGACCAGCTACGTTGCGGTTATTCCCAAGCCAGGTGGACCAGCCTGTGGGTATTCTGTGTGGATAACCTTGCAGGCCTTTATCCATGGCGATACAAGGGTTTGCTCCGTTTTCTGAGCAGCCTCTCTTGCGCTTTTTCTTGTGGGATTAACCTTCGCCGCTGTCATTGCCCCTGTGCACAAATAACGTGGAGCAGTCTGTGGGTAAGCCGGGGAAGAATCCATGCAGGCCTTTATCCATCGGTAC
+
B>B@@>;ABB:CCBD@CC>CBBB<CJ?CBB?BBB=AA?A@@;?????=?A>B>BB?BBBAAABAC??@???'ABBACCA@@@@@>A@B?B>AA>A@<A=>??BC>BB?B@=@@B@BBCCE<BBC@CCA@@CD?CCA?C@C?A@?>;@4;;/;AA=A;;7;A=?=99277(33(39/,(,,,,&,,-577954.49;44.43//8888'//(////(/8386;481732+26555::<49===2?@@@@B===8>B=BB@@<@@?????@=88818A;AA=CDD6@:==8=A5;;@@@C>E<CC>C@@=@BBB?ACC
@MDX4E:00692:05780
GTCAGGAGTTCGATCCTCCTTGGCTCCACCATCAAACAATCGTCGAAAGCTCAGAAATGAATGTTCGTGAATGAACATTGATTTCTGGTCTTTGCACCAGAACTGTTCTTTAAAAATTCGGGTATGTGATAGAAGTAAGACTGAATGATCTCTTTCACTGGTGATCATTCAAGTCAAGGTAAAATTTGCAGAAGTT
+
C?CCC:CCC?BBBDC@CB?B?B8;<B@CD?B;;;C=BB@C:;:AAAF>BBBAA@@A=>?><@@=7??;??;?@@<@@A<@@@@9@@A:>:992:???=BBB:>>??<?BC7?>>=/<9;;;3;??@>>>@@==9<<=8;;;;<=7<?>????>>5=;;;?;???BACD=AA4::??8<5:;>=/=?4<66--(--(
@MDX4E:00692:05792
CCGAGCGGATCCCCGGCGCGATCCAGTTCGATGACCACCCGCGACTCGTCGGAAAGCACCAGCAGGTGATCGCTGGCCTTGTCGTAGTAGAGGCTCGACAGATCGGTGAGGAACAACCCGCGATCGCGCTGCGGGTCGCCGCCGACGCTCAGGTCGAGCGCCTCGCCGCGGTCGTTGAAGAAGCCGTTTACCTCGATGATGCCCACCGGCGCCTTTTCCCGGGCCACGAACAGGCGCTCGCGCAGCGGGTCGTAGGCCAACCCCTCGAAGCCCTTGTTGCGTTTGTTTGCACTGCCCAGGGAGAACTTCCGGGCGTTGC
+
C@CBBBC?B@AA@7A@CCCDCBB?BBB@CCCDCCB@ABB<9::BCCCCCCCACC>AABD>@@BCC@CBCCBBCAA>@@D>BABCBDECCB??=?BBBBBBBBBBB@BBBB?@=AA7::7;???AAAAA<<<<AA9@@>?;;;:=A>>>AACD=AA=>?AAA<>>@@<@AA;A@?>;@A8=<=CC=AAA3:;=?>>BBBCBAAA:@B>A>@??288829A=CE=B?BBBB@B>>:=@@AAA@@@>><@@7?>>>>>9;4;0666(8:::9>>A:A<@A;@@AAA:>>>8>=AAA;9:3:=<5=AA<@>;>=DD:;;::>C
@MDX4E:00693:05781
CTTTCCACCGCCGCGAGCTGGCGGGCGATGTCGAGGCAGGTTTCTCCCCCTTCGATCATCCCGATGACGTGCCGCAGATGCCCCTCGGCGCGCTTGAGCCGCTTCACCAGGTCGGGATGGGTGGTGTGCTTATGCATGTCTTCCATGCTGAAATCATATCCCCCCAGGGGGGATACTGCCACTGGATGTTAGATCAACGGCTGCTTGCCAGGCGGGGGGGAATGGTCGCCGAGCCAGG
+
CCC?C@BB?BB@BCCCCCAA?@CC<B898BCBBBB>BBB=??:>==>>?1??C@>A=A??C7?>>>>=889=8===>=55769+=?>=???C>>;>@@@<?@A=A@@<??;?==95=?@A:AA=@@@@@@<@AAAAA@@>><:9=///=;9;1@?>==889998%522222#27789:;6:89928;36135;@DC;CC:A??<<8:969A:==AAAAA#A<A=4;9//-/===7@@<
@MDX4E:00693:05782
AATTGCGGCCAGTTCTTCATGGGTGCGTGCCGCCTCGCGCAGCGTGGTGCGCTGCGCGCGAGCAACCAGCACCAGACGGGTGCGTAAGGGGTTGGCCAACGCTTCTACTGCTGCCTTGTATTGGCTGCGCTGCTTTTCCAGTTCCCGCCAGCGGCCCCAGGCACGACGCATCGCCTTTGCCTGCTTCCAGAAAGCCGCTCCATGCGCCCGGCAGTTGCAGCAGGCGGATGGTGTGCCCGGTAGGAGCCGTG
+
E@C>AAD?C@CBB?BB@BBBBB<BBAB@BC?CD?B@@@CC>@=>>D<??<<;@@A@>>>BB?>><><>>>@@<@@@>>>9>A>>>A<AAA2>9=:>;@=@@@A=A@@>==@@@A=D:??@@;>:>>?===AA?9;9-906//*/=0777<:==<>DD5;;8<??CCCAAACCCC@BC@CB?CBBB?B@AAAC<?>>AABB?B998;;?7@;@===<@>>>@==:=A:>9949<<>?@9@=AAB<>>=<@@@
@MDX4E:00693:05805
AGCCGACGCTGTCCAGGTAGTCCACGGTGCGCAGGCCGAAGCGCTGCAGGCAGAAGTCTTCCTCGTCGAGGGTCTCCGCCAGGTGGGTGTGCAGGCGTACGTCGTGGCGCGCCGCCAGTTCGGCGCTGGCGCGCATGATCTCCGGAGTCACCGAGAACGGCGAGCAGGGCGCCAGGGCGATCTGCACCCGGGCGCCTTCGCCGCGCTGGTGGTAGCGAGCGATCAGTCGCTCGCTGTCGGCGAGGATGGTCTCGGCCTCCTG
+
CAA>AFBBACCBA>AB@CCBBC?BBB?BBBBBBB>B?BB<??BBBBCB><=?>>;@@@A;A7;;=@@A??@9?CCC@CB>BA=@@@=@BCCCCD@AAACCEBBBBB?BBCCC?BB9;;C>;;7;@ABC@BCBCCCDBBBCBC@C@CCBBBB@CCAA>BB>ABA@@CCB=CAA>ADD>DABBBBCCCBB=BC=BBB?C?CBC?BCCCAA>AB?BC@??CBBBADBBBBCCCCBBBBBCCC?C@??=?AC@CCDBB?A?AD@BA
@MDX4E:00694:05804
GATGCCGTGAAGCATCTGCAACGCCTCTACGATGACCTGGTCGCCGCCGACCACGCCAAGCCCGGCCTGTTCGGCAAGCTGCTCGGCAGGAAGTCCGGCGGGCCGGTGAAGGGCCTGTATTTCTGGGGCGGCGGTCGGCCTGGCAAGACCTACGTGGTGGACACTTTCTTCGAGTCGCTGCCGTTCGAGCAGAAGTGCGCACGGCACTCCACCGCTT
+
//9<?@CCCH@B:;5==8999@AA<@@9:4>=:<4858?<=879;@A>ABC@999C=A588A8?<?=B@@=8858B<?@CA;;881/997<)//6/53/76(54:4955-59(2+255575-5@=>>-66///(-7907-/.47838//,69968=59949:88:8399.55;9:55555:399375555966277::555862.--220--)-550
@MDX4E:00695:05770
CGAAACAATCGGGAGGCAGGACTGTCGCATGCGGGAGAACTCCTGGTAAGGGGACGCGCGCGTCGAACGTGCAGGAACGGCAATGGCAGGGCAAGCGTAGCGCGCCCGGGGAATGGCAGTTTGT
+
955:1:;79:;;09=3</0)////8986;>885@7B>>3<=<29<66926;;+5225555......(.66;;991717949<4791556=.7707:7766////881788.<.56068///(--
@MDX4E:00695:05782
CCGCTTCCCGATGGCGCATCGCGCCACCCTGGTGCGCGAAGCGAAGAACCGCGGCCTGCACTCCAGCTGGATCTTCGCCATCACCCGGCAGGAAAGCGCGTTCATGTCCGATGCCCGTTCCGGAGTCGGCGCCACCGGACTGATGCAGCTGATGCCCGGCACCGCCAAGG
+
B@CCC?CE>DC?;>?BBDCCBBB@=9998:@?BBBBBCC?BBCC?BC@B@D9999@CCCCCED@CCB??;?@@@>ACC@BCBAAA:A=@BB49979BA@@C?CECBCC?CBCCED>CCAC?B<@?>9949@@<AC<?=?CCCDCCCB::;BBA;;;6;>AAA?;;6;>@=
@MDX4E:00695:05791
TAACGCCAGCGGCGTTATCCGCCTTCCGCGAGCGGGGTGCGGGTAAAACCCGGGAGTCTCAGAAGTCCAGCGCCTGCACCCCTGGATGCTGCGGATCGAACCCATCCAGGCGCATGCGCTCGGCGAATGCCTCCCGCGCCGCGTCTCCCTGGAGAAACGCTCCCCGCGCCGAGGCCCAGTCGTCCGGTTGCAGCCGCACCATCCAGCCC
+
@C@CCC@CCBB?BBB?BBB>BB@C?B@CCBCBA@@@6999DD>BA@@6>>:?D>BBACBBBBB=@@B>BBBBC>BBBBB@A5AB?BBBBBBBB>BBBBB>BC;BBA?B@<@@>BBBBBBCCD@BBB?CCC????<????>@@BBB@AB<BC@@@@A9@@?AADD5>=@@;@<<8<A9A>==AAA;A9>688>>>;<<>?;>>><@@??7
@MDX4E:00695:05798
CGCGAGTACTCGCTGTTCCAGGCGGTCCTGCTGGTCATGGATCGCCTGCGCGAGGAACATCCCGGCCTGGGAGACGAGGCGCTCTACGATCAGTTGGAATTCCAGGCCAATCCTAGCCTCGGCTTCCCGGGCAGCGATGTCGATCGGGTGGAGTTCTTCGAAGAGCGCGGCATGCTGCGGGCGCGGCTGCGTTTCAACCTGATCGGCTTGTTCGGTGCCAGTTCGCCGTTGCCGGCGTTCTACAGCGAGCAGGCCCTGGGCGACAGCGAGGAGGGCAATCCTACGCGGAACTTCCTCGATCTCTTCCATCACCG
+
BBBB@AA000@@AECC>A>BB?999:B?BBBBC?BBCCC?AA@996;BABDB??<A;<<;;;1:4::>>>8==>??=>:=?A>><<=899=>@@<@<>;<<>=?>:=<A<BB?AAA?<BB=:=>7<=28807CC<<>??>:9:9988.7718:;5;D=@@>;??A>>>D<:<;@?>>=:919<////@@=AAA7AA=C<@;==AA;>>=@A<>>8;=;<@AA;???=AB<??;>;AAD=;:;>>>@;;;=@?9@@9@@C6>>@@@??===;<=<59:5661688==A=A;AA=D;A<==@@@@>9>=>>888=;
@MDX4E:00696:05766
GCCGGCCCCTTTCAGGTTGTCGGACAAGTACGATCCCTGTGCAATCCTGTTACGGGGGTTGAGTATGTTCGAGCGGAGCTGAAAGAGAGCACTAAGCTTGATGCTGCGCTGCGGGGTGTTGAATGTGTAGTTCATCTAGCTGGACGAGCCCATATCTTTGGAAGGCAGCGTGATTCACTAGATATTTTTCGGAAGGTGAATCGCGATGCTACTCTGGCGCTTGCTCGGCAGGCGATCGAAGCATCTG
+
DC?B=@@@7A<4@A@=A<?>BB>B@C>AAAAABBBB>BCBBBC?BB@BBB@BBBBBB1B?BBBBBBBC@BBBBBB?BBBABBC;@@@@@<AAAA<AAA;@???><=B????=AAA5<<9=AA;=><@@@AA=BA???AAA@@<@>>>=@=3>:557;@8@<@<?<@@@@=777@;AAADAA@>99797+;A=A=A<???=CBA???===BA??AAA<?@@@;>>?@A=B=>:>A;;>@@<@@@@AA?
@MDX4E:00697:05780
TGCGAAACTTGCCGAAGACCCTCAGCGGATAAGCGGACGGGTTCATTCTGAACTGCTGGACATGGAGGGTTACCGGGACCTCTCCGCAGAGGCCCGTGAAAGCGTCGACGGAGTTCCTGGTCTTGTCTCCGTGGAACTCTGGTGCGAAGCCCTGCTCAGTGGCGCCGGCCTGTCCGCCGAGGCGCGCGAGGTTTTTGCCGGCTACGGGCGGCGCCGGGCACACCAGGGAGTGCCCCTCCAATCGCTGATGCGTGCATTCAGCATCGGCATTCGCGAGATCTGGCAGGGCTATCGTGGAACTGGCCGGGG
+
>AA@@@8;;.4:5:::;834/39::=>49>>4>>A186B<6>688;69:;;8;<@AAD8;;>?>:>>>6><@>9@@8>?8;;AD=@;:;@@=AA:AA?>>9>>>>;9://*/:<6<28?36560///6;3:;94;*-,,,,(,--56057=055587==8818;;8=;A:?@;;6;@=???=BBB@@@==9=???/?A=C====>>D88818;:4;=4=>=<<6<<A8>>>@@AB5BD<@<@;;<C>?>?@?;;:AA=>?>?;;;B>B??;?@@@AA;;;?>:=888-8<<<:;;;5:9===8=;???5
@MDX4E:00697:05793
AAATACCGGTGTCCGACCTGGAGAGGGCGATGCGTTTCTACGCCTCGGTGTTCGGAGTGGCGTTCGGCGAGGTAGCCACCCCTGCACGGAAGCAGAATGGCGCATTTCCCCTTCGAGGAAGGCCGTGACGGTGCCAGCGGCGCACTCGCCGAGGGCGACGTCTACGTGCCTACGCTACATGGGGCGATCATCTACCTGAATGTCGCGGACCTGGATGTCGTCCTTGCCCGGGCTCTCGGCGAAGGCAGCGAAATCCTCTTCCCCGAAGACGCCGCTTGGCGACGGCGTGTTCATCGCCGAGATCAGGGACAGCGAAGG
+
CG>CBC@C@BBAC?BBC:BC9=BBBB=BBBBABBCD><<<BBB@CA@=ABB>BB=BBBA>BCC7@;;@@@A<>>;:48888'5==9:;<@;<====9=?<?@@BAA-777(89>>?A<@<@=B=@@AA@@<?><9=?@@<@B>>>>;;>;>AAD8AAAA:;:@@@@>>>;>AAAAABAC5555,8>?@@A@@@@@;@AA=@??AAAB:>>=AA<AC???@>>;><@@D9AA9@??>==:>AA<A:??@989917617;;1666-:<5;//.737<=:><@@@A@<>>=??<??@@=>:=AAABB>>;7=A?;<;<161
@MDX4E:00697:05796
AGATTTATCTGGAACAAAGTACAGTTTTTTTTGCGAACATTTGAGCCTGGCCAACGTGACCGTGAAGCGTCATCCAGTCGTAACGCGACGCGTAACCACTGATTTTTTCCCCGCGGCATCATGTAGTATGCCGCGGCTCGGACTACAAGGCCGTGCGGCCCGGGTCCAGAGCTGGTCTAGAGCAGAGTGAGGCAAACAATGACTGAACGCGCTCAAGTCGGTGGCCTGCAGGTCGCCAAAGTCCTGTTCGACTTCGTGAACAACGAAGCCATCCCCGGAACCGGCGTCTCTGCCGACACGTTCTGGACCGGTGCGGAG
+
AABBE?DDCBF@B8?<<39<<9999999999"498939444)4::?286:C8A?A89/79)//9:3/5555<;<8<==55557:89;<;:>=>@2945<??=@A@AA%;;;*59:;>AB@<A@A@?AAA::6:??9?@BC????AAA<@==:>>>?A5;:6:A:BC;>>???>>:>AADA>>>>>AAAAAA<AAA7>><@AA?@?A====AAAA?<AA>>8>>:>;???AA<A?@@<AA9>>A<A??<?>:::<@@@?>:?@=AAA:??6;6666(78<8?=A<>>@@@AAAA<A@?>=@A;A>>9>><>=A>>>;A>
@MDX4E:00697:05801
CTCAGGTTGTGTGGCTCGTTGCTGTCCACCAGGATGGCGTCAATCTCCATGAGCACCTGGCCGGCCAGGTTCTGCCCGTTGATCTGGACACGGCTCAGGCGGATGCGCGGCTCCCAACGCATGAGGGCCATGGCGGTGGCGGCATAGACCTGTAGCCGGGTGGTGTCGTTGAACGGAGCATCGATCAGCTCCGGCAACTGGCTGCCATATTCGCGTCGCATGACGCGGGTACCGATGCGAGTGGTGAGGATGTCGGCGATCGACTGGCGGATGTGTGCCAAGCGGTCGATGGCGCCGCCGGTATGGG
+
ACCCF@B?CBBBB?BACCB@BBCCCC@CE@BB>BCC@CBBBC?CCCC@CCCCABBC@@?;?4939?@@=A?AAAAD7==9==@@@D;??@9948<>??<?A:>A@@;;;=A???9?=B888@@?>?8?568A<AA=>>:?@<;;;>AAA=??>==C7;;7;E=A@@A@C<>A:AA7::@?@?@>>>???@A<@;;;7;BB=BAAA=A>==<@@@ABBAA?;;;?>>>>7>>>5;;@@@AA@?><AABA<AAA@??;><>>?>@@>>:>>9>>>>@@??;?8<<>;AA<><A;<<<:@@;@;A?===6
@MDX4E:00698:05781
CCCTGGATATCGGGGGACATCGCCGATACCAAACCAGTCTCCATCGGCTATCGCGCCGACATCTTCTGATCGCCCGCATGGGCACACCAGCACCCGCCATGAGCGGGTTTTTTCATTTCCACACGAGGAAAACTCCATGTCCGCAAGCCTCCCCAACGGCGCGCTGCTGGCCATTGCTGCCACCTACGGCCCGGCTATTCCGATTACCGCTGTCTCCAACGCCAAGCCAGCGGTTGCTACCGCAGATGCTCACGGCCTGCTGGTCGGTGACGTCGTGTCGCTGGTG
+
BC>BB@BCEDBBBBB5BBBBCCC?@ACCD?BB=B?BBBBBA;@@8848@CA786>><>>AACBB@CCFBBBBAC:@AA?AA<ABABC@AA@CDD>DDBBCAA@AAA0;;;;;%;CCD?DAGBCBA@@5;;;5;AB?CBBBA5::?6:9?BABB9B@DD@@??BBBBBCC?B>AB?B@AAC@CCACDBB@BD:;:;CCC@C@CBA?BB@BBGGDEBC?B?BCCBE?BB@BB@@=@?BABCB@BDC???CCFFCBB?B?@@@AA=A;;6:A@@@A:::AAAABBB?BC
@MDX4E:00700:05770
GGTATCACCCGCCTTTGAAAGCTCGACCAAGCTTGCAGCGTTGATCAGTTGAAGGGCTCTATCAGACAGCTTGTTCGTCATTATAAATACTCATGGCATGCCATATGTACAATTTTGTGAATTGCCTTTATGGTTTGTATATATGGCAAATTCATACGATTTGCCGTAATTGGTGAAACATAAGGTACAGCTATGGAAGAGTCTGGAATAGTGGGGTTCACCGTTACGAGGTGCTGTAGAAAAGGTCACGGACTTCCGCACCGCGCCGTTCTGCTCG
+
C@CCDCBBB=BC6887:CA;A???>;B@D?BBC?BAAB=>=>BBBCB@@<>@77868@@>A?>=<>>AA>=4>A;AAAAAD<AAAA7>>AA;<;A<AA:5:4>>A???=<<6???4@?@@?B<::=EF<A::5:=5=<>==>>9:4:>>4@=ABBBBBBDC=@@::9:8<8<;?@@@9@@::4:59;?>>>;;;;=B=@>>>@@A=A=AAA@@@@5=:=A=69969///959>?;;6;:9::(/*/89AA=AAA=A=B@@@<@@@@<AA:>8:8<=@
@MDX4E:00700:05781
CCGACATATGGCGGGACAGCTGGTAGCCGCCGCCCGGGCCGCGCACGCTGGTCACCAGGTTGCCACGGCGCAACTTGGCGAACAGCTGTTCGAGATAGGACAGGGAAATGCCTTGGCGTTCGGAGATATCGGCCAGCGAGACCGGACCTTGCTGAGCATGCAGCGCCAGGTCGAGCATGGCGGTTACGGCGTAGCGGCCTTTGGTGGTCAGACGCATGGGCTTTTCCCATCGGGATCATTCGGGGTTGACGCGGATTATGCTCTTATCCGAGTAATTAGGTCAACTATAAGACCGATCAAATTACTCAGGATTAGGCAAATTCAGGGCGCTACATGCTAGCAGAAAGCCGCCGGCCGCGCATTACGCGGCCGGATTGCCATCTCGTCCTTGACCCGGCGAAATCCTCCTCGCGCAATACCGGCAGATCCTTCGCGCAGTAGTCGCTCCCCAGGGCGGTCGAGCGCCTGGCACAT
+
J@CCDDDBBB@CCC=ABAADAD=??AA<9>0779(73(7/37?@?ACAAA?BBA@???:?:::066939@?@<>>?D:>:B=@@A::9@<?AA><;;B=@@BCD-88-8::18188=<=:8816>>;>>9;6;<ABBA@@==8=;==8=5;877@@@ACDCCCBBB@DD@@??BAAAAC>AA=A>AAC?BBBBBBB@B?BB>B?BB=BDA@A@88::BB8?;>>/;;3;???C;B;;;A:;;;;/;:==ABBC?BB<;000;;?;>::49ABAA?B:;;?DBB?BBFAA=@??4:9???A<A;??CAAA?CD@DA>:::8:?BAAB;:99?AA@988@A==<766(6:656(/(/(/57=<B9=9;//)/596//(3;1;;;;775@1717555(549555)5;389422.6...29;:9<9::9=;;/7/7=>///////6..25555)222'22+22266888353(.----
@MDX4E:00700:05796
GTTCCGGGGCGAAGCGGCCGAAGTAGGCGGCCATGTTGCCGACGTCGCGTTCGAGCATGCTGAACGCATGGTTGTTGCCGGCCGCGTCGACCGCCTGCGGCAAGTCGATGATCACCGGGCCATCCGGACCGAGCAGGACGTTGAACTCGGAGAGGTCGCCGTGCACCAGGCCGGCGCAGAGCATGGCGACGATCTGGCGGATCAGGAAAGCGTGGTGGCGCCGTGCCTCGTCGGGCTCCAGCGTCACGTCGTTGAGACGCGGCGCAGCATCGCCGTCGGCGTCCGCCACCAGTTCCATCAGCAACACGCCATCGAGGAAATCATAGGGCTTCG
+
BBAB:B>>2=BB@BCB?A?CB@AA@@=996:<AACB@DD@@@???000A@?@BBBCCCCBCBD@BBBBCCAD@AB>AB?C?C?@?@?AAAB@AA>ABBB?AA?BDCBB@@<>>@A;AA9A:BA?;>6><8?ABBBB?ABBB@>?=?BBB>BB8979CBB?B;;;BB===:=:=8=@@@A??=AAA<AAA@8:8A;?<@B<@@BAA=AB=BBB=A<??<?@B6:8@A=B??@@>@7AAA=@@>@@>@AAAA??;?@@BBC>>9:::::;>>>AA;@@6616?>>9><;AA;C>>9>9>@>@AAC:<<<>>9><<;AA;AA7>==>AAA7;;7;?
@MDX4E:00700:05805
ATCGGTGATCCGCCATTCCATGGAGAATTCGCGGGCGATCGGGGCGAAAGCCTGGCGGAAGCCATCCAGGTCGAACGGCAGAGAGTCGGCACGGATCTCGTGGCGCATGAAGAACCAGCCGTTATCGTTGTCGGAATGATGGCTGGCTTCGGTGATCCAGCCATTGTAGGTGGCCAGGAAGTTACTCACCTTGGCAACGATCCCGACCCCGTCGGGACAGGCGATCACCAGCCGAAAAGTGCGCATGGGTATACTCCAGAAACATCGCGAAAGGCCGCCATTCTAGCGGCATGGCGGGAAAAG
+
CCDDACDC=>9;;4:99=:@BB@BBA@D@CBBBG>AABBAAAA7AAAA;@A?A@=A@=A?AB@BBB?BB>BAAA?CA>AB>>>;;;??:=??C?CBBBCBAA>@DAAAAA@CC?C?BCB?BB?BABBB=A=??<?<@?@??8;;A<AA:>?<BA@@@=A@@3>>:>ABB=>=7@=AA<@8;;=@A@A?>:?=D=AA=A===<<6=>AAA3??AAC7AAAA<????@@A;<<=7==<=2=BBBAA<<=D:>=>A>>==?AAA7?>@@?<==C6868:>>:=>9>>?>@@;:8;A<?>?8?@>2>
@MDX4E:00701:05773
TTCCGTCAAGCGTTATTTTCGAAAATTTTCTTTTCTACTCAACCGCTTGCGCCGACCTTCAAACCATCTTCCGATCAGCGGGAGGCGCATTCTACAGCGTTCAAACTCGCTGTCAAGCACCTCGATGAAGCTTCGTTTCGAATCCCTTTTGGGACCGAACCGCTGCAGCGAACAACCTGCCGGAGCGCTTCACCACCCCTCGGAGAGAATCCGTAAATCCTTGATTTTCAAGCATTTACTCTTCGTCGTCGCCGGGAGTGGTGCGCATTATAGGGAGATAGAAACTGGCGTCAACACTTATTTGAAAGAACTATTCAGCTTTC
+
G;GACCBB@BBCC?BCCC9BBCCC8?=8079:9+9<<>::?>B=A@C<>>?>499?=A<@CB:C;???@=D:<==>>>>=A9::8;AABA49?AABA;<;;?@D:A@===>>>@A<A>>><>>=>:;::=<A<@@@A:A?>9=??7?AA5DD:@>.760718>>>>?>=;;5;;5:<AAA<A<AA@@=<:<<;9=@AA6AAA<@@>>><??<@A@A9A@:>:=CCED;CC=@ABCF=???BB@BB@@@@>>>=AA:788=>===@AAA<==>BB8=>>BBBBC>CBB?A????=@@A=:>=B9?@A:AB=??>><?>>ADC;B
@MDX4E:00701:05799
CTTCGGCGCTCTGACAGGATCCAGCTGCCAGGCATTGAGTCCCGCGGCGAGCGGTTCGCCATTGACCTCGTCATGCAGCCCCGGGTACTTGATGACCACCAGTTCGGTCAGCAAGCTGCCCGTGCTGGCCCCGCTGAAATCCAGAAGCGTCGGGGAATTGGACGGCGTGAAGCTGTACAGGCCGGTCAGGTGCCACTGGAATTTCTTCTCGTCCTTCCAGCATTTGCCGCCGTTGCCAGTACACAGGTCGATGACCGGGTTGAGCATGACCGAGTCCTTCGGCCGGTACGACAGCTCCGTACCGACGGCCCAG
+
CC@CDABBBBBBBCAA@>ABB>BB@BBB>==;8AA;@>>;99/97959><>=>7;8<5818A=BBD=DD>>>>>@A888>>2>@9@@AA=??;97705=7<9;:>?:=??@@@5@===>@:@@@@>=9=>>.<=>@@@:>>;???;===@@@@A6?<?=B>B>>;>>>AB<AA;=>>>>>:><A;A=;;=AAA;A<==;A<AA:>><<<<AAA=A<A<A???AA9AA<>>:<=9>><@BB@?@?;;5;8666;<;0:9398<<=@@>>>A;?:;;@<;5;=690606;=AAAACA@@7=AAA;>:::;AA7>>
@MDX4E:00701:05806
GACGATGGTTGCCCCCTCACGTGCCTGTCCTAAAGCATTCCGAGCCTCCTGGCAGACCTCCGCTTCCTCGCCATAGGTTGACCAACTGTCGTAAGAGAGCGAGTGCCATGAACAGTGGTGGGGCGTCTGAAGTAGGTCGTATGCCAATACTTCAGGAGTGAGTTCATACTTCTCCCAAAGCCGTTTCCAGATAGCTACCTCCGCATCCCCTCCAGTGAGAAAGCGAGTGGGATTGGCTGCCCATTGATACGGTGAGAGGTGAATATTGAGGATCACACTGGAATGGTTTTTCGACAG
+
CCBA<@@<@69;CDD3BBBBAABB=@ABB>AA@9@A??588=;BB<>?=AA?BBBCC?@=8::?<@=@BBC?BBBB=?=@?@;@=A????:;:39:?==>BAA@@@<@CBB>B@<;;46677)8>>?=;;5;>>>:?>>>====181;C;;8;AA>A@@D@A@@BACB@@<@BA@<BC=CC@BCC>C@CCCDAA@@BBBDD?BCCBAAA8@@?ACBCBABB<BCCBBBCC<==;8;?=BBD>@B>AABABC?ABBA@@<>>>=@@@<@>><>A>>?AAAA<>68:<@EDD/>>@AA=
@MDX4E:00702:05786
CTTGACCGGAGCTCTGCAGGATCTAGCGGATCAGCTGACTTCTCTAAAGTGGCTGAAAGAGCGTCTGAAAGAGCAAGGAGAGGCACTGAAAACCTCCCAGGAAAGCGCTGATTTAGCATTGGCTCAGTACGGTGCAGGACTAGTAAGCTATTTGCAAGTTATCTCTACACAAAGTGTGGTGTTTAGTCAGAAGTTACTATTGTCTCAGCTGACATCTCGCGGTTTATCGCTTTTATGCTCAAATTAAACAGAGCACTGGGAGGTGGT
+
CC@BDD>B?BCCBBECBCB?BAAACBDD?BBBBBABCC@A>@BBA@B<@BB@BCBBB<BBBC@@BBBBC<BBBBB>B>BB>>9BAAAACAA5>;999+9@39929@AABBBBC>BAA9949;>@@ABBBBB@B>>AA<>>>==>A9>>@>>>7?>@<@@;@BAA@=;=A>??7=====:@==>9>==BA@@<>>:>ADAA7==AAA@>>>?>BBA;9;>=A06618>>>8///)///;96::.<8>?9?CABBB@?;;=59929929
@MDX4E:00702:05791
AGTCCTCAGAATCCCGGACCTTCCAGTCTCAAGATCTATTTCCGCCTGTTGGGCTACGTGAAGCCCTACATCGGAATGTTCCTACTCAGCATCGTCGGTTTCCTGATCTTCGCGTCGACCCAGCCGATGCTGGCGGGCATCCTCAAGTATTTCGTCGACGGCCTCTCCAATCCTGACGCGGCATTGTTTCCGAATGTGCAGTGGCCCTGGTTGCGCGACCTGCACCTGGTCTACGCGGTGCCGTTGCTGATCATCCTGATCATCCTGATCGCTGCCTGGCAGGGGCTGGG
+
CCDD@DCDCB?@@@8><9:6;>B@CDBABBB?AACCBBBB>B9><9>?@?AC>BBBBCA?@:888)9A???CC=A>ABC?B?B>798>>?@BCCBBC@CC<B?CCCCBB?BBA@?@;::B=BBC?BBCCBBB<@AA=>>>?;?=?:<;777)8::;==AB=B<????8<5:;;>>AC?>>>ABB>BBB<B??;8589;?885A<@@:@@9=9:;;>>@@=@@@@><>><@@@A>=995:<<;?A<AAAB?@;:6;7===///==9@@@>>>@@==8<A;AACDE2A8883
@MDX4E:00702:05793
GCAACGCCAGTTGCTCCGGGTTGACCAGCAGGGTGACCAGCGCGTTGCCGATCATGTTCATGGTGGTCTCGAAGCCGCTCATCATCAGCAGGTGGGCCATGGAGACGAGTTCCGCCTCGCTCAGTTGGCCGCTCTCGTCGGCGGCCTGCACCAGCCCGCTGTAGACG
+
>>>=@6;6:@A<BCCC@CC>C?BBB=AABCBC;??AB@DB@@@??9??<@AABAA>>9A@>>;>A<@@@@AA<@@<A>>><966///9A>A=A@@6@/00@=@@BB;=;@,0,0;=@>DDDBA??;?>A=B@@;;889//)/;595:>>@?;?;;;3;A@AB?@>CB
@MDX4E:00702:05808
TGCAATTCCGCCCCTGCACCGAGAAGCGCCTGTTCAGCATCGAGGACGTGGCCAATACCGGCCTGCGCCGCGAAGCCGACAGCCTGTTCGACGACGGCGCCCAGGGCCTGTTCGTCGACCTGCGCGGCACCATGGGACCGGCCAGGTCCGCGGTACCGACGGCAAGCTGGAGGTCAGCCGACTGTACCGCGTGCAGAACGAGGGCCCCGGCTGCGACGACCCGAACTTCAAGCTGCTGACCTTCGCCGCCAACGGCAACGAACCCTTCTGGAGCGCCAGGGTGAACAACAGGGCCTGCGCCTGGACCGCCCCGAACACGAGACCCTGGCCTTGCCTTACGTCGCCGAGGAACTGCCGAACGGCAGCACCAGCTATTCCAGCGAGGCGAACGGCAAGAAGGTCGAACTGTGGATC
+
BECCAE>B>@@BB:BCCCH@CBBB@CCCD?BBB?@AAC??8B=B@CBAAB594:=BCC@C?C?CDCCD<??CC@CC?CDBBAA=A??<?A>9////)/99=0?>B<@=@AA>AAABB@@<@>??8818==8====6==5:5:+//06638;=9A>=9=@<<9=@<@>>>;==8==?;;5;;A>==>A=@@=;;;BBB?CCBAA/;;;6;@CBCBDCC;;<A;@A>BCAECACCDABBCAB>A?BAB?BB?B@@A=@B>BBB?BC<@>@@A>BCBBB?CDD>DBB??=9=9::,:3::CDD@CC@DC?AACC:CC<??@A@?9;;0;@>A?C@CC@C?@@@@A@>=@::5:>AABC?CC>???AAAAAA?CC>;;;8=8<<:;8819>>:981/<7;<,/,/;@>9@@9885::=
@MDX4E:00703:05760
ATTGCATCGCACATGACCACCCAATTGCATTGGTGCTGACCACCGTTTGCATCCGACTTGGCCAGTCATGCCAAAGAGGCGACCGGCAGAGAACGGCCACAAGCGGACGTTCACGAGTGAGGTGCTGGCCGGCTAGATGGTGGTAGCCAAAGACGGACGTTCACGTCACCTACGCGGGCAGTCCACTCATATTGACGGCGGTCAATGGCATTTTGCCTGCACACTGTGACTATCCCTAAAACTCCACAGTCGACTAGCAGAAGGAAATGCAATATGTCCGGTTCAGGCGGTAGCTATCTAGGTCCA
+
;A<;;;::::;;=66669==>7=8=5::8:59-3344::;7>?9><<0<8:9=2944:5>7@:CCCAA@BB?BA9A@@7:9DC>B@BDCCCC@CB?A=B;:24<83;>9:8ABB7978888<?@BBB?B@D?@@@@=00*/5.3:7:8;;2>7//(/5791:;???>==;>>>>898*8><;<9=886:/--)--,-055(--/(396;;;::*..(/8689975//....55<:.5///(/886//.6333>:::>9977375=A7529B<@@A>><;A7:7::A;BB?B;;;@BB?>:;06637
@MDX4E:00703:05782
GCCAAGTCGCGCTGGTCGGGTTGATGACCTCACGGCTTTCTTGTTCGAGTGCTGCCGGTTTGTGCCAGAACTTCGTGAGTCGATTGCCGGTGATACGTCGGAGCCGACGCGCATTTTTTGTAGGGGGACAACTGCCGCTCACTGACCATGCCAATGTCAGATGCCGGTTGTTTTCGCGGTCCTGCATCACTGGCTGGAGTGCAACTGGAGCGCTGGCTCGTTGATGGCTTCCGGAGGAAGCGACGCTTTGTGCTGGTATCTCGGACGCCGAAGGCCTTGGCATGGCATGGAGCCGTGCCAGCCTTGGCCCGACCACTGTGCTCGATGTAGCGG
+
;;GF?BBBBAAA@@=?>>>5:57;@AAA6?87971222)279AD<@@@??;<69=:>8=>3?58:8>8?;CD=ABB@@;;9755+22+20677:;@///@7@;;4687;7::::<<<=&55>@CCC.55...../(.6333558.-(----,306625298356)/)/)/688-8==<:::4997=A@AB@>:=99378<==?=@@@977B===C?AA@9/)/9--).-6>6@:=A7?;>@@@@;:??8?ACAAB@BAA>===;???<7;@,0,0=@=C=@@AA=@@@@>>>>:>AAA<??@<><A.5516==8:;;AA@@@;:;<<==8881
@MDX4E:00703:05796
TAACGAGTCAGGGGCCGCTTGTCCGGCCCGGCCGCGTGGGCGGCCACGTCAACAGGAGAGTCAACAGATGAGTCTACATGCCGCGGCAGTCGGTCCCTCCGTGCTTCCGGACCTTCGCGAGCAG
+
:A>BBB@AA@@@A7A@CCC?CCC@B@BC=B@C8:9A@@>;??9?<@ABCBB>BBC?ABBCCCD@BBACCCBAAABBA??>=;?9848ABBBC?BBB>BB>BBB>>;><B>BB@B?BBBB@@B@@
@MDX4E:00704:05798
CGCCGGTCGAGGGATCGGGGGCCTGCCCGGCGTGGATGACCCGGGTCGCGAAGGCCTGGGCCGGGGCGTCGGGATGCTGGTCGTGCTGGCTCATGCGAGCTTTCTCCGCAAATGGTTCAACAGGTCGAAACGGGTGATCAGGCCGTGGAAGCCGCTGGCGTCGGCGACGATCGCCACCAGGCCGCG
+
@997:?AABBCC>BDDDDDD1D@CBCB=B@BBBD=@?>???9@B<BCCBBB?B?B@BBC=B?BDD8AACBBB9@ABC@@;?=@@@CAB?BCECCCCBBBCCE>CCC@CBBB<BC?C@BE@CCC@CB@@@<@AA<AA@AA9879@CDE>B>A@<?BBB@BBBBA?BBAA??=AAA<?>9@@=A=AA@
@MDX4E:00705:05760
GCCTCGTTGTCGTAGGTGCTGGCCTGGACCAGTCCATACAGGTCCTGCAGGTGCGGCTTCTCGCGCAACTGCTTCACGAACTGCTGGAAGACGAACTTGAAGCCTTCCGGGGTGGTGGTGACGTCGACACGGTTGCGCAGGCCGTCCACCCTGTAGCGCATCCGCGCGATGATCTTGCGCCAGGCCTGCTGCGCCTTGACCAGCGACAGGACGTCGAGCTCGTCCACCAGGGACCGGCCGACCTTGAAACCGACGATGGTCTGGGGCTTCTCCATGGAGCGGCAGATGATCGTCGTGCGGTAGGCGCTGCCGCTGTAGAGGTGAACCTCGT
+
CC@B@C@@DCCABBB?AAACC@B?BB@CC@CCBB?@?@@AA>AB?BBBBB@AA@B?BC@BBBBBBCCADBBBEBEBBCD@CCBABB?B=A?@BB<???AA>BA?B?B?CFE:AB?AC@BC@@@B??BBBBB?B<?>BBAA>B<AAC?B@@:??B=><??>:95;=>>@A==>B??:668=:==:=<@A@@@>>>8<;>>?<AAA?>=>>;A=???AA@>>A>>>9=><>?B:@@;?=A=AAA5;8<AA:@;@>>8::@<@@ABCC2;;:>>@=AAA<AAA@:A@?A?@<===B>>>A@@<@AA=@@@>>@;>>>@A@><<;AAA<A<AAAA
@MDX4E:00705:05793
CCGACTTCCTTGGTCCAGATGTCGTAGGCCTCGTCGTCGGTGGCGTAGACGGTGACCCAGAGCTTTTCCTGGGCAGGTTCAGCCATTTCTCGCCGGTGAGGAACTCCCAGGCGTAATGGATGGCGTCGCGCTTGAAATAGTCGCCGAAGCTGAAGTTACCCAGCATTTCGAAGAAGGTGTGGTGCCGCGCGGTGTAGCCGACGTTTTCCAGGTCGTTGTGCTTGCCGCCGGCGCGCACGCATTTCTGGCTGGTGGTCGCACGGGTGTAGGCGCGCTTTTCCAGGCCGAGGAAGCAGTCCTTGAACTGGTTCATGC
+
G@CBBB?B@C@C@CC?CBCDBBBBB9898@CDBBACBBA@BB@=>>>>>@@<@;>;?9=>=7::::/:1::909<=8=;>>BD@CCD>BB@??>A?BCBB?C?BCCC=BA>@CBB?BB?BBB?BBBBBBBB@=@DC=BBBCBBB>@??CDAAC<A@?BBB>B>>>@@:@??9?@<@;;;;B=B@?;@@B@@<:<;>@C?B@?9999-98AB@CCCC>AABBCBCC@CC@B?ABABBBB@@@CE>CCB?CCC???<?CBCBBBB<BBB??=>DBBBBCB:C@BC??:=994949:>>>E<A<?@<@@@<@<???@@
@MDX4E:00705:05794
CGCTGCAGCCGGTCAAGGGCCGCGCGGTAGCGCAACTGACCGCCAGCGGGCTGCGTGTGATAGACGACAGCTACAACGCCAACCCCGCGTCAATGCTGGCGGCGATTGATATACTGAGCGGCTTTTCCGGGCGCACCGTCCTGGTCCTCGGAGACATGGGCGAACTCGGTTCCTGGGCCGAGCAGGCCCACCGCGAGGTGGGCGCCTACG
+
BDCCCABAC>A<ABB?AB<B?B@@@C@BBAA@BC@BBBBB@BB>BBBBB<B>><<<AAABA>??CBCCDDCBBBB@CCB=?9>==3=?@@BC?BBC@@@9979@@@?AAABBBCCCBCAA=ABBB9C@CC=???@G@ECB@CC@BB@BDD@CAAAAACC>@?A?CBBA?C?C?AAB9B>@?A?//,0@7@A;@@@>@===<5<@@<@BBB
@MDX4E:00706:05780
GAAGAAATGCGCCCGCTTCGCGCCGCGGGTTTCCACCAGGGGCGCTTCCGGGGTCTTGTAGACGTTTTCCATAACTGATCCGGCAGTCCTTGAGAAAAACCGCCATTTTGCCTTCCGCCGCTCCGTCAGGCCAGCGGCCAGGGGCGTTGCCGCCCCGGCCGTCCGATCAGGCGTTGCGGCTGGGCGGCGCCATGAACTCGGGACCGACCGGATCCTGGATGGTCTCGGCGAGGATCCGCTCGATGCGGGCCATGGCCTCGTCGTCCAGGCGCCAGCCGAAGGCGTCGGCGATGCCGTTCAACTGCTCCGG
+
BB?BBA;AC>:::5;AA>A???@<AABB=BE=B?BB?A???5>;:D?B9???5;;;5?A@<<?8888*8:??B=>>>@AB<><=>>>@<@=>>>AAAA/><>@:????5?B=B:=:;;5;?>><>BABA;@<@@::7;;>>BB6B>>6<<98888)8:=8=;;5:?@@@@<B@@=>>><??AA78819<=<ABAA<AAACD96638?>;@<>>><A@>F>><>>>=E=@==<=D??49<AA?AAA?==7=<AAA;A;A><>AA??:?A<AAA===>=BB:>:9///8386::@A<@@<>>:>;;;@@<A<
@MDX4E:00706:05786
CGACCGGATCTGCTACCCGATCCCCGGCACCCTCTCCATGGAACCCTGGCAGAAGCGCCCGACCGCGCAACTGCTGATGACCATGCACGAACTGGAAGGCGAGCCGTTCTTCGCCGACCCCCGCGAAGTCCTGCGCCAGGTGGTGGCCAGGTTCACCGAGATGGAACTGACCATCGTCGCCGCCTTCGAGCTGGAGTTCTACCTGATCGACCAGGAGAACGTGAACGGCCGGCCGCAGCCGCCGCGCTCGCCGATCCTCCGGCAAGCGTCCGCAGTCGGTGCAGGTGTACT
+
CBBD@C@AA@CCCC?>>7?A@@@A8A@CCCD=AAAB?BBB?C?CC>BB>@@A=5;;;;=4=>?:>>@>>9=AAAABABBB@<@??BBAAA;??@=C<@<???@A<AA<AA;@=;7=AABBA/???>;AAC9>>A;;7<A;>><>>:>:??<@<???<@>@???<A=?=>>A=BAAAA???5AA=D=AA;;<>A<:;;<???D=DDD:::>@<@A<CBA=@@@??=?@<@<?<@<?@?@@<@A====;3333-2933-7;6;9AA<??@@D=??==;@@;A><<<:@AAAAA
@MDX4E:00707:05760
CGGAGTTAGAACTTCGAGATAGTGGCTCATGATTGTTTCCTGACAACGAACGATGAATTCCAGCTGTTGCGCACAACAGCACGCGGGCCAACAGATAATTTCCCGTGCCGGCCAGACTATGAAGCATGAATATTGGAAAAAACAAACTTTTCGAGAAAATAAATCACTGAACTGCGGCCCTGGATAAAGTTGAACGGCGATATTCAAAATATTCGACACATCCATACAAAAAGCGCACACAGAGACAATAAAAGAAGGATTACCAGCTAGCAGAAT
+
CC?BBB>BBB@BB?BBBBBBBBBB?BBBCCCCC@CBD@CABBBCC@CCC?B@@@BC@C@C@CCCBAB?BBBBCBD@BBA=AAC;;;9;@C?ECD??>39928A8A99:?A?A?BAAABBDCD?BBCBBB?ABA<@399999%:::,:;;;.;BB:;;;.;@@:@B@?@@B7;;C;;7<C<@A@C@?@:@@<@B@CC@CBFECC?CCCC6AAC?CCCAAABBB?ABCCCBBB1:<AAAAABAA::;>=87776(8=9>:<=9<>:<<<=:;;AAA<A
@MDX4E:00707:05767
GTAGAGGAAGCGCGACAGCGGGTAGGTGCCGTTCAGGGCGTTCTGCTCGTTGTCCTCGACGAAGGCAGCGCCTTCCTTCTTGGCCAGGGCCACGGTCTTCACGCTGGCGGTCTTGTAGCCGATACCGGAGTAGCCGATGCCGTTCAGCGACTGGCTGACCGACTGCACCACGGAAGCCGAACCCGGCTGCTCGTTGACGTTCGGACGGAAGTCGCCTTTGCACAGGGCTTCTTCCTTGAAGTAGCCGTAGGTGCCGGAAACCGAGTTGCGGCCGAACAGTTGCACCGGCTTCTTCGCCCAGTCACCGGTCAGGCCCAGGTCGCCCAGG
+
CCCCBA?A>@@BBBBAABACC<B<<7<@?>@C>B?>>7CDD>AABBBBDD?ABC@CBBBDBB@B@BAAABB>B?B@C?AA>B>?>@@@<@<@@C?BBA?BCBBB::6:?9>@A=@BBAB?BBBCCAD?BBB998=?@?@@=@B?BCBBBDC>A>@AAAA;>>>A87>?498=:?:@?;?@9??9?=@9::AB@@=??@@A<@=:=00,0;??098@CD=BB@@>==8=A;@@<@=@=AA<A????:>A>>:>:;5;8==5<:<><<8<<=:==BA;@@AC<>>?@;?<<<8<=8=>>?8>>=>=>;><?CAA<AB:@@:==889-8>9
@MDX4E:00707:05797
CGACATTCTAGCCGATCGCGCCGGAGCTGGCCTCCAGCGCGGGAAGTCCATACCACTTTAGTGCGCATGCGGCAAAGGTTCACAGGCTCGCCGATAGGGGCCAGAATGAAAGGCATGTGCCTTCTCAGGAGTAGTGACATGCCTCATCCGCTCACCCTTTTGCAGATCAGCGGACGCGGCTACCCGCCAGC
+
CCBBBB?BAA??<??:0//88397399BB=@?CB?BBBB@@@8>;;9<:=A>@<>=AB<B@AABBA@?@7748CD:><>@B@@??;;;;>?;C=;;@CC2?=A>>:=>AA:A<A?>>>?@<?<?A>>>=CA@?<<=B@@=;?=AA@>=8???AAAA9<<<2<>>>@@@>>>>8=9::=:>BCBD9??:?AA
@MDX4E:00707:05801
GAAAACGGATGCCAAGGCCCCTCATCTTTCCAGGGAAACCCTATAAATGCCAGTATCGGCAATAAATTTCAACGTGAAACCGATATAGATCCGTCGCACTCCCCTCTCCAGTTCGAGAGATACTACAACAGCATTACCGGAATGTGGACGAACACCTTCCAGGAAGGCTTAAAAATAGTAGGCGAAAATATTTCCCTATCTCTACCCGATGGTCGTCAGGAACTATTCAGGCTGACTGACGGCGCAATATCGTCCGACGCAACGACGGGTACACTTTCAAAAGACCAGGCAGGCTGGAGGTATGACTATAGGGACG
+
BDDD9CD;BAAB?A=@2787*9@@?>?@8??ABB>BC>DD>BBBBB;>;@=BA@>>8828A<?AB=BC>CE@@99:99+9;>@AAB==;;;<??BBB>>6666(7<<<;A?@8;;B@@AAA?<<:::6;9::@B@BC@D?B@988A;>8885;;;5;;@<@@;?3818?:?@@@/>>AACA;<::::-:999/:;3:::<<>;;;A:;;:=:=??@B>>;>=BABB<A::49:99@@???@<<668<>>>AA>><::;@@A:==@AAA:@@===BB9>>AA5;;;;==8=>=:>;;58818=>>???>>>@A:@AB
@MDX4E:00707:05802
GTGTGGCTGCCTTCGCCGCCGACGATCTTCAGCAGGCGCTGGCAGACGCTGGCGGTGAGTTCGTTGAAATCGCTGTCCCAGGAGCCCCAGTCGACCATCATCGCCCGACGGGTACGGTAGGAGGTGGTCAGCGGACCGGGGGTCAGCAGGATAGGTGCGCGTTCGGCAGTGCTCATGCTCATTTCCTCTGCGGGAATCGGCGAAAGAAACCGGATCGGGCTTCGCGGCCCGGGCGGTCGTTCCGCGCCGGCGTTCCGGGGAAGCCTGGAGACATAAG
+
BBB;98:ABCAE@CCB?A@>@CCBBB?>;?A@@@A=@@@??<?BCB@B>><;;<49<<::5;??=AA@:@@@@BAAAE:;;=AA@BB9BBBB?;;6:0==000A@000CBB9B@9949?@?CC?CA;>>?B@@<>=8<>>=/=>BBCCC?CBA@<@BAAAAA=AB?BCCBCCCCCCECB@@@@<?<AA??>AB=B@DCC@AA@A9?==5<8<399@AA=994:@??<?C=AA;9929?<=<??BCDE<>588@7<4;;;/;=AB:<=;AAAA???<B
@MDX4E:00708:05792
CCGGTGTTCACCGTCGAGCGCGTCACCCGCCGGCAGAAACCGATCTACCACAGCACCTACACCGGGCGTCCGCCGGACGAGCCGGCGATCCTCGGGGTGGCACTGAACGAAGTGTTCGTGCCGATCCTGCAGAAGCAGTTCCCGGAAATCGTCGATTTCTACCTGCCGCCGGAAGGTTGTTCCTACCGGATGGCGGTGGTGACCATGAA
+
C@C?CCC@BBB@BCCCBAAAACBBCCC>BC?C@BCBBE=B>BBBBBBC>AA?@@BC=??BBB>BB9B??A065<A=<>>787<A<>>>::7;@@DF5=><@@=>=@<@?@;?>==:=D@??;?@DD=@@@B>>;>?>=<59:3::>@9@@@=<=>>=5;;;>;???;??6;6;:>5><@A<@<@>>;><AAA=BB=;;7;==@<@>>>A
@MDX4E:00708:05804
CCGGCCTTTCAAAGCGTTCATGCTGGAGAGGTACCGCGCTGCTCGAGGAAATTCACAGAAGGGTTTCCCGGGGGGTAAGGGAAACGGCACTCATCTGGATGGGACGAGCAGGGGAGGCGGCCGCCGTCCTTGTGGGAACCGGGCCGGAAACTTGGCATGCTAACGAAAATGCCGGGGTCGCGGGATAGACATTGGTCTGGCTGTCCTTTTGTTGAAAAACGACGTCGCAATCAGAACAGTCCGTAGGCACCGGCGCCGGAGCGCTCCGCGTTCCTTGCCGCTTGCTGTCTTCCGCCTGCGTCGGCGGCGTCATGCGGGGGGTATGC
+
B@C=A?AK?CCD>BAAC@CBBAABB?BBBB>CBB?C?AAAABBB???29829?ABBBB@<@A:@@-88-8>>>A)<=8;95;>8?C@DBBAABCCBA?ABCD>B>>AA?>>>>2;;5;?;?;>>=@AA:>:=A@D:B8;8;C:C:=:=A388=A=BA>>>@>:=8888(5:94===3=>?>>>9>D>>>>>>:?;???>;;;;@A=BBB5A=566666)6///<<@AAA<@@>>A=AAAAA:>>AC;A>>9>;>>>;A;??>==>>:>>>>8<5:2777==>=@>>>>>>;?9;;7=??????;<=8888===A999999&9A>>>
@MDX4E:00710:05770
ATTGGCAAGGGTGGAAAAAAGCAAAAGGATGCCACCCCAGATAACTCTGGAAGAAAATGGATATTTCATGACGAACTCACACCTCATGGAGCGGGGTATATACATACCCCGCCCATGTAGCAGAACTTAGTTGTATTCCAGGGTGAAGGGCAGGGAGCCGTTGGCAACACCTGCCGTAGCGGCCGCAGCGCCAGACTTTACGTAAGCAGCCGCAGATTCAGATTGGCGCTGTAAAGGGTGATGTCTTGGCCTTCGCCATCTTTTCACCACTGGAATTCAAGGG
+
BA>A<@C@CC?CC>A@A@@)?AAAA7A=BAA@><;;<.;@BBC?CBBCC?A>@@@@8@C@BCBBB>BBBCBCBBABBBBCCC?C@@@A>BACCDE;BBB??>A?><===+00>5@00/>777=@=BK=B;;5;;;>9>:?>?4>>>188)/9991///7;=6<38=9=@A<A@@;;:::;@<A=>>;=///9==@=??:?A==:,//9//)/66>AB;?<;8;6;=@BBBBBCD?GG?BCCCFCCC?A>A@D@BA@=AE;;;;.<<;5999?;>:?499:>>8
@MDX4E:00710:05792
CATTGAGGAGGGCTGGTCCCTGATTACTCGTTCAGGGACTATCGGTCCGCATGGCCTATGTGCGACCGGACATGGCTGGCCTCGCTTGCTCAGAAGACGTCTTGCGAGTAGTCCCTGACTTGGACGCGTATTCCACCAGGCTACCTGTACGCCTTCCTATCCAGCCGCTACCGGCGTCGCCCCTGGTCGTCTCGGGCACCTACGGTGCCATC
+
A::5;::.::;,9776:>@+00=<<@=@@??8>@@=2?786552/77/55;BD>A<@A@;;:BBBE@C?@@@9:20//)069//7C??>=888>8888::?@;A=;;557;;>C;@@AAA7;6.--.-666175;9)/.)----06:::3445:4949722.5897662,,),),,,-,299+2508<;=@@@AA3;;;4;///37--)---
@MDX4E:00711:05760
TACAACGCCTGCTGCCACTGCAGGTTGGTGTTGACGACTTCCTTGGAGAAGGACGCTACGCCGTACCCAGCTACGCCTGCCACCAACAGGCCCTGCACTCGACGGATAGCCGCTCCCATGCTATTGAGAGCCACGGTAGAGGTCCTGGCATCGTTGCCAATGCCATTGAGGACATCACGCCGCGCTCGGATTCTGTCCAAGGCGCTTGCGTACGCCGTAGCCTCAATACGACCAGCACGAAAGTGCTCGGTGAGCTGTCGTTCCTGGTCCGCCAATTGAGCGAGGGAGCGGTAAGTTGGATCAATA
+
ACCA?A;:6;CBBCB@BBBCA::8:<@=@CC@CCBABBB>B?B>D@BBB=@=@BCCDCBBC?ABBAA<ABABBBBB?BBC?CC@B=???;BC8;;CCCCCCCCC@CD???000AAD9@CCBA??<??>@AA@CBB?A@@8849=:?@<@>CBCC?BB@B@@@@@BC?BBB>ABCCCBBBB=@@BCBBB?BA>BBBBB@C@C@BBBB898BBBBBB?BBBBB?BBB@BAAABB?B@>>>AAA>BBBBCCC?CAAACDCCCCC?C@BB@>><>C>B?B?BBB@@@AA9:;:@<>=8=?8<8<=7949B
@MDX4E:00711:05764
TTCTATGTGTTAGGTGTAAGGAAATTCTGCGCTGGTAGGCCAACTGACTCAGCAAGTGCCGCTTTATAACAAGGGCCCAAAAACAGTGTCAAGAATACCTACCGACTAATGCGTGCTAATTCGCTCCTTGGAATCAGGCTCGCGTTTTTCATCCTTTGCAACCATCTCCGG
+
A>ACECCFBB?@@=@BCC?C?AA=C?CCCCCBCC@BBC@B?B@CCBCCCCCCBB?BABA?BBBC>BBA?BC?CD=BB=BCCC1B8::BBAA;>>;>AB<???<CBAAA=AA====DCCAC@BBBCC@C?C?A?BA?=;?FCCEEDDDD0DBCC?@@=@AB?B@CCBBB89;
@MDX4E:00711:05793
CAACTGGCGGGCAGCCTGAAGCCCGGCAAACCGGTCTCGCGCAGCGCCAGCGCCCCGACGGCCCTCGGCGGCAGCCAGGACAGCGGCAACCGGGAGACCGGTACCGTGAAGTGGTTCAACACCTCAAAAGGTTTCGGCTTCATTTCCCGCGATTCGGGCGAGGACATCTTCGTCCACTTCCGAGCGATTCGCGGCGAAGGCCACCGCATCCTCATCGAAGGCCAGCGCGTGGAGTTCTCGGTGGTACAACGGGACAAGGGCCTGCAGGCGGAAGACGTAATCGCCTCCCGCCGCTGACCGCCGCGAAAAACAGA
+
:::;?D?BBC<BBAC?ABC=@?C<@=@@@;A?@>BBBBBBBBCCCB>:>=:8988-767;1995;A?6>@;<@>>;<A<A@A@@@;@;8=8<=5<:;;;C@CAB?>>>A:>>B<@<@D<@@@<B?@@?6@:@A;@@>AC@BCCC>>>7=>8885;=@7?888<?@AAAA;?==><??@<@<===A???=AAA>=DAA7;7;<??;>>B@@<@AAB>>>:=:=<@@@@>>>B=B>=:>???=@@<>>>@>@??9?AA<AA9A=AA:::3::3:9<<:;:A<A>>>=@@@:@A<@@@A?>:=A;<<77777+:>>A
@MDX4E:00712:05771
GAACACGCCGCCATCCGCCAGTGCGCCATGCACGCTGGCCAGGCATGCGCGCAAGCGCTCCAGCCCTGCGTTGTAGTGGATCGAATAGAGGAAACAGGTGATCAGGTCCAGCGGCTCGTCCACCTGGAAGCCGGCCATGTCCTGCCGGCTGAAGTGCGCTTCGGGGCAGCGCTGTCGGGCGAGGTCGAGCATCGGCTGGTTGATGTCCAGGCCGGCGCTGCGATAGCCGAAATCGAGGAAGTGCCTCACGTGAGGGCCGGTACCGCAGGCCAGGTCCAGGTGCCGCCGGCCCTGGTTGCCGAACAACTGGTGCAGGCGACGCACGCAGTGGCTCTGCGCCTGGTAGTCGATGTCGGCGCACATCAGGTCGTGAATAGTGGGACAGGTCGGTGTACAGCGCAGTGGCCGGAC
+
55.59455744.56>9>?<>=?=:47-559::?@BCC?A=@@>@AC@ABBABB>@??432268890999??6:;AB>=155666278866269/6799>>@?>>>=;;5:>6718AAA>?:>@:>>9>0886949)..3333>=82616755/5:89=<;2;;::.;75:A;;:A;::6;>>>;===AB;;;>>=@AA<A<BCA@@B3889=;?:==A::///9;:C@?@@:?@?@A?B:?>9;6:@?:99>???:@=A@CDD@CCBB?B=??>AA=@A?AAA?BB=A=AA;AB?B?BB@DF@??=?@@;999@@<@9::BAB@DAAA??:?@:9:??A=AA?B@@ABD:9:?AB;??BBBBBA<>8</////*/;;;AA:?=??=A>>:=9657@?>?;9888(/*/49;
@MDX4E:00712:05780
ATCGCCGGGGCGATCATCGTCAACACCAAGGACCCGACCTTCAGCCCCGAGCTCT
+
CCCFD?BBB9BDCCCCBCB9::@CCD@C>C:==B<BBB?B>?>7777+.2,**((
@MDX4E:00713:05791
TCGGGGGAGAGCAGGCCTTGCTCCTCGTAGAAGCGGATGGCGCGGGTGGTGATGTCCAGTTCGCGGGCGAGATCGGAGATGGTGTAGGTGGTGGACATGCGCAGGCACCTGCTTGTTTACCTTTACGTTAACGTAAAGCTGCACCGAAATCCTGTCAACGCCTGGAACGGGGGGAAAAATGACAGCCGTGAAAGATACTTGTCAGAAAGATTTAATCGGCGCCTCATGAAAGGGCACGGATGGCTCTGTTCTGCTTCGCCGAACACTGTGTTTCTCGGAGGAGTCGTAACGATGAGTCG
+
>;;;;;*9@@AAB@<?>A>@ABA?AADBBBA?BBB?BAA>CBBCF?FE@AAB;;9@<@9825;;?<8BBCCGDCC:BBC@?8<??>C8BC>BB?AA@:::5;;A<AAA:@;556;=@///2;9088=?;?<85299097778:=/556-554::88869=?<BC<A9688888$6888)887>=9:08556;4<=//.8466::565,59=<0;6;??;?AD=AAAA:992:?5?A@@<@==9=?><>>:==?>=:=??=@A=A@@@B@>>=8==??<@@:>><9=;94;3333;;<<;
@MDX4E:00713:05809
GCTCCGAGATCATGCTGTTCGAACTGGACGGCACGGACTACGGGGCCGATGTGCTGCGCTTTCATGGACACGCGATTGCGCATACCCCTCAGGAACTGGCAGCCGCCGGCGCCAATGCGGACCAGTTGCCGGCGAAGTCGATTTGGTGGCAGGGGAACGAATACGCCGCTTGGCCGGTGCAGGTTGAGGGCCTGGAGGCGAGCGGCGATGGGGCGTCGGTCGCCCGAAGTTCACGGCAGGTAACGTCAATGCACGCATCTCTGCGCTGTGCTTGGCCTACGACGACCTGGCCAACTTCCGGCTCACAATCCGAGAAACACTGGCGAGATACCTCGACGCTGAGAA
+
CBAADCBCBBCCCCCCCC>AAC@CCC@CCC?BBBB?CCCC????6?<@BBDCCCCCBBBCC=CAAA@CCABBB9::ABBBBBBBBBB9BBBC?B?@@@=A>>><@@9<:=??<A;CABB@BB@BBIACB?B@CCB@BBB:;:A9@5::=AACCC9@=?BB@CCCCC?CAB@B@C=@>@@@??;=<=999,9;AA?::6:@A@AA?AA@9999+:@:984:<:::/::478/7>>><@@@<@D=BAA??;?@>>=CBAAA???A@@@>>==;=;A:?:??@>>>;;;9>@;A6868A=A;A<=====>9AA;A:<:C7@@=>>;A999A>??;A>:::AC>>>@@@
@MDX4E:00665:05812
GCGGCTGGTACCAGCCGAACGGCCTGCTCCTGCTGCCGCCTTCGGCGTTCTTCCTGATCGGCCTGATCATCTGGGCCCTGCGGACCTGGAAGAAAGACCAGGTCGAGGCCCCGACCTACAAGATGGCCCCGCAGGTATCCAGCAAGGAGGCTTACTGATGGAGCACTACATCAGCCTGTTCGTGAAGGCCGTGTTCGTCGAGAACATGGCGCTGGCGTTCTTCCTCGGCATGTGTACCTTCATCGCCATCTCGAAGAAGGTGGAGACCGCCATCGGCCTGGGTATCGCGGTGATCGTGGTGC
+
AA@=@BC?CCC?ABB?BB>BB>B>BBBAA<@DA?AB7:9@E@BB?AAA?>><>?@ABBBB@B?BBB@@BBB@BB=CD>CCBB<???BB??;87748>?<9939AA??>;EE6@AC>B>>?<@@??;AAA2AA??8<<>>9>?@@;@8=<9==:ABBBBBB?AAABBBBB@>@AAA;<<><>@AA?:;:<;@>==:>?@A???@=A=>><A??A@<>>>;>@:=:>A@<@AAAAA>==8<9>>>>>?8<<>>>??:?>;@;??<>>:94:=8=@AA9=:=>A5==>;;;?==>=@AABD;??@
@MDX4E:00665:05826
CGGAGATGAATCGCCTTGCGCAGGTGCTGGAAGGGCAGGGCGGGCGCGTCATTGGCGTGAAATTTCGATGGCTTGCGCGATGCCCGAGTTGAAGAAGTCGGCCGATGGCATGGGGATTCGCTTCACCGTGCTGGCCGATGATCCGGCGCATCGCTTTCAAGCTCCCTCGCAGCGAAGCAGTTGCCTGTCACCTGATATCGTCGATGCTCGGGGGGGAAATGCGTCAGCGTCTGCTGGGCGAAGCAGACGGCCGATGGCATATTGAAACAGCTCGAGGCTTTGCGGGAGGAGGCTGATGGCGAGGTCTGCCTTGCATGCCTATGTCGGCGGCCGGG
+
AC>BBBAB>6<>00,0:;:004=8=>?>A;?;>A;A@BB=>>K:@>>=679?;>2:77622'26.6886615808>>:76////'.6774==69:5:;>99=5=>;;6;AAAAA3@?<@>>?=AAA;;;;<8/)/4899/..74;.8889<///--'-93...8;075557999;57---7*--27-//;=665:>>98:A><89///58<<<<9#77/688999997;;><==777.6//)/969799497975737----(/77.75559777:5>?C9A;<<2//+/<7<?????<???A:996//)/6889///699=?@<<8:;5:;A@9
@MDX4E:00665:05846
TTCATGATCCTGGTGACCGTCGGCACCCTGATCTACTGGCTGAACCCGGCCGGCAACCCGGCGATCGACATGGCCGCGCTGATCATGATCGGCTTCCTGATCTACGGCCCGGTGATGCTGATCGGCTTGCAGGCCCTGGAGCTGGCGCCGAAGAAAGCGCCGGCACCGCCGCCGGCTTCACCGGTCTGTTCGGCTACCTCGGCGGCTCGGTGGCGGCCAACGCCCTGGTCGGCTACACGGTGGACCACTTCGGCTGGGACGGTGGCTTCAAGCTGCTGATCGGCGCCTGCCTGCTGGCCAT
+
D>EDCCCCC@@@>@DBB>ABBB?AABB=BBBBCCCCCC@BCBB;@A9?;?4:4:@<?C<@=A@@@ACDCBBBACACCCBBCCCCCCBCCCC@CC?B?BBBBCCB?@;?@;@?BBAABBBCDDBC@CC?A@@@4:;0;A=BBACB@BBC@CC?A@@;@@@@8:8:CC?CC999=@<@A=AAA@B=;;;@?<>><>@@@<?@@<>=6<A9:4:=89:7:;@<>==B:CB<?8/,/:9:///69@68938AA;AA<A>==5=;;6;B=@@9@@///:=??@>=>A=;;:<AAA<@@>99/5/6:
@MDX4E:00666:05831
ACCTCGTTCAAGGAGGCCGCGCTGTCCCTCGAGGTGACCCCGCAGATCACCCCGGACAACCGGATCATCGTCGAAGTGAAGGTGACCAAGGATGCGCCGGACTTCGATCGCGCACTGAACGGCGTACCGCCGATCAACAAGAACGAGGTCAACGCCAAGATCCTGGTCAACGACGGCGAGACCATCGTCATCGGCGGCGTGTTCAGCAACACCCAGAGCAAGTCGGTGGACAAGGTGCCGTTCCTCGGCGACCTGCCTTACCTGGGGCGGCTGTTCCGGCGCGATACGGTCTCGGACGTGAAAAACGA
+
AA>BAA@;;;5;=?=6@?@@BDCBBCC>CBBBB?AABCCD:???BBAAAAAA9A?C@@?A@C@BBBC@AABBBB@BBCC=@?ACCB?C>B>A@@BAA?A?@CC?BBC@@ACCBBCBBB?BC@DBBBB@BB<>>B>B?BC@CD@CBBB?BAB?BBB@CACCCC@BB@BCC?B@@?@=@@@ACB?BBBBBBBBBB?BB?BBBA>:>AABA=><<<7<>>@AA=AA@@;@A<@??9=:;;:;AA5:6;==8=@@@<>>><@<?@;??DD5@@:>7778=394:;::>>??@<@A@@@=CB;;;=AAA/BBB
@MDX4E:00666:05838
CGCCAATCCTCGCTGTTGCCGGTCAGCTGATCTTCGCCGAGGAAGTTGAGAATGACTGCCAGGTCGCGACTGCGATCGAGATTGTCGTCAATCAGCAAGAGTTTGGTTTCGCGCCACATTTTGATCAGCTGCCTTGCATCGAATGGGTCTCGCTCGACCCGAAAGAGGGCTGGGACTAATGCCTATTTCTAATAAGCAGCCAGCATTTGGCCACTAGTTAAGTCAAATGTGAACGATTAGTCAATTTTATGGCGTGTTTTTTTTTGCTGTTTCCGACAGGGAGAGGCAATAAAAAACCCCTACAGACCGCATGGAAAG
+
CCC@C?CC@DCCAA@B@BC@B?BAA===BBBBB?BBB>BCC>>:==<@@@@<@AAA@;=:=B=AAA??>>=>=AAA@=>>?C9>>=>>>>:>>>?@><>A8886;=BD;<<<AA;>>7777)8:;>A>ABCC<?<@ABBBBB????88:;A@@AB???B<AAA8@:99,9A@A<BCCC@BBB?BBBB=BBB?BD?AAAAA<A>@<<<6>9>=BBB>>=;B??>7=@6///;;6<>>>=B???A;>??3??@9>>:888887767"8>>>AC:D=?>>==<3::BB;;;6899999%9;<+//6==>>7;;?@@<@@9?
@MDX4E:00666:05849
GTTACGCGACGGTATCAGAGTTCCTTGACGGTGCGGACCTGGTCCTTGTTCACGCGGGCGCGCTTGCCGTCGAGCTGTTCGAACTCGTAGAAGCCGGAATCCTCGTCATAGGAAGGGGTGTCTACGGCCTGGATTTCACGTCCGTCGTTGAGGGTGATCACGGTAGGGCTGGAACAACCCGCGAGGGCGCCGAGGCCTACGGCGAGGAGGAGGGCGGGTAGCATCCGCTTGATCATTGCGCAGTTCTCCTGTGCGGTCAGACTTTGAAGTTACGAGTTTCTGACAGACGAGTTCTAGGAAGAGTTCCCCCC
+
BB@BCC>BCDC@CABAAAABC?C>B<A@BB?BCBB?BB@>>8>A7:5:A;==<=665-8==?@@:BB@BCCCBBBBBB=@@C@BCACBAAA=BB?B>A>BB>BB@AACBBB@@:>>>2>@AAAAAA<?<>>=???8?AAAAD<???=<8<===8>A@AAA@A<@@@@9>BC?B>A@=@A;ADBACC8BA@=@;;7;@CCCC@CFCC?@=:99:,9AA>DBBBBBB?BCB>AACBAA=BB???AA=A@@8;;A?;;7;BAAACDD;AA<AA388>;;;@8CCCCDBBBBD@@@?BCBB?B@CACBACDDDD*
@MDX4E:00667:05820
TCCAAACGCATGGAGAAGTTGTGCCGCCAGTAGCCATCAAGACTGTTGTAATTTCGGCTGAGGATCAGGGCGTTCCCTCTACCGCCCCGCAGATCTATTTCTTCCTGATATTTATTGCCAATAGCGAAATTTATAGGGTTTCCTCCGTACGGCGATGGGCAAGATATATCAGAAGGACCTTTGTTCTTGGCGGGCTGTGTTTTGATAACGCAAGTTTTCCTGATCTGCTTGGGAGCGATAGTCTCAGATCTAGGCCAATAATCTTCGGGGCATGTCCATACTGTTTGAGTGCC
+
@C=AA<BCBCCFACBC?AA>AAAA@BB>BBBBBC@BBBB@BBBBBB@BCC@CC=::9:CBBC@CCBCCC=A@A>AA<BCB?B=:;;;.;BCABDBBDDE?CBABACCCCCCC>BB@BB@C?BBBA@@C=CB>CBBBB=BB>B@CD@BBBAA>A99:CB=BB?BBBDA@@@AAA<A=@@<@@6;;:CC<A=ACC=DCBB@@@@8@ABB?CFBA>999929<ACAAA??@C@CC=CCCCBBBBBBBCCCB@AB;;6;?B?BD@CBC@@???6?ABBBB?BCCBBBCC>B@@ABBB
@MDX4E:00667:05833
GCCACAGCGACCTGTCGCCGCAAGACATCAGTCGTGGCCAGTTCGTCATCAACCTGCTGACCGAGGCGATGTCGCCGACCAACAGCCTGAGCAACCCGGCGGCGGTCAAGCGCTTCTTGAGACCGGCGGCAAGAGCCTGCTGGACGGCCTCGGCCACCTGGCCAAGGACCTGGTGAACAACGGCGGGATGCCGAGCCAGGTGGACATGGACGCCTTCGAGGTGGGCAAGAACCTGGCCACCACCGAGGGCGCCGTGGTGTTCCGCAACGACGT
+
CC@CCBA@DCC@BBBBCD?A@B>AAABBBBBABB??;>=@>>;?;;;DCCC@D@CA@ACCD@CAA?BBCCCDBBB@BBD@D?AAAB?CC@A@@;?<3=9994::4;BE?CBCBB?BB?BBBBB?A=??<?B@C@@@@BBBBA?A>>9>=B>><=>@A?>>>>@C?B?BB?BB?BBB>BB>BB>BCD>BBBB@CBBA?AD?CC?C@@@C?DC@B?B?BBBA=ABA<BB@CC?B?BC?C?AC=CC?CAAA=ACC>B7757A>8=8>>@<@@>@@A
@MDX4E:00667:05847
CACAGCCTGTACAAGCCGTTCCCCGGACGCTTCAAGGACTACATCGCGATTCCCAAGGCCAACGGCACCAGTCGCTGCATACCACCCTGTTCGGCATGCACGGGGTGCCCATCGAGATCCAGATCCGTACCCGCGAGATGGAGGAGATGGCCAACCACGGGATCGCCGCGCACTGGCTGTACAAGTCCAACGACGAGACGCCCAAGGGCACCCATGCCCGCGCCCGGCAATGGTGAAGGGCGTGCTGGAACTGCAGCAGCGCGCCGGCAACTCGCTGGAATTCATCGAGAACGTGAAGATCGACCTGTTCCCGGACGAGG
+
AAA@@@@BCCCBB>BB=?B5999-9:@=@=848=6:>BBBBBBBCA>89:49A9B;?<@@B?BD?BAC?C@@AGBBBD900B,000*0?@:@@>BCCBCCCCCC:CCBB>BCBBCCC::9;BBAB@BCBBD>@@@CBBBB?BB@BBBBC@C?B?A;=8;;0;@@>?>ABAABBBB>AABBBBA>AAA=A>AAA:9:@AA???8?<@@8>999+8556:1;:;<A7A<;<6<<677;/8829@???CC;?<?AACBB>>A???AB:=:=A6;;>@>>><?<?;@;;;====:>@@@A=A===ADD=A??<?C9><>>>>@<
@MDX4E:00668:05827
TCCTTGACATCGAATGCCGGCTCACCCAGACGGTAGCCGACGTATTCCAGGGCAGCATTGCCGGAATAGCTGATAATCGGGAAAACGGACTTGAAGGCCGCGTGCAGACCGATATCGCGGAACTGCTCCTTGGTTGCGCCAGCCTGCAGGAATTCGCGATAGGAATCCAGCTGGATGGCCAGCAAATACGGCACATCCATGACGTCCGGCAACTTGCTAAAGTCCTTGCGGATACGTTTTTTCTCAGTGTATGAGTAAGCCATCAGCGTTCCCCAGCTTGTCACCTGCTTGTTTGGCGTCTCCGACGGG
+
;B?D@EBBBAA?@<@<939>;95ACC=@@AAA<ACB@=ABBBBCC?B?BAD588?9934;=7=>B?BC???==;;5:9:917==.7929:<7=A<?;?>???B@@???A<A>>>A;;;?=>8=6///:5:28.3.59:>=@@B<>>=>==B<?<?@>>=<9<2<:>?:?;;;><>BB;><>A:;:3;>>>9?=:;596::88899<6=-./49969==BC:BCC=A<@;:27999265555$58695355?@A?>=>=BB=<;;==9996>>>///66)/.88;2;;>A8;<A8>:>AA@A@<@>>>A:
@MDX4E:00668:05830
GGACCGAAGAGGACCAGATGGTCCTGGAGCGCGTGCAGTACGTCAGTTGCCCGGTGCTGATCGCGGTGAACAAGACCGACCGCATCGAGGAGAAGGCCGACCTGCTGCCGCACCTCGAATGGCTCACCCAGCAGTTGCCGAAGGCCGAGGTAGTACCGATCTCGGCGCGGCACGGGACCAACCTGGACGTGCTGGAGAAGCTGGTCGCCGAGCGTCTTGCCGGGAAAAGCGAGCACTTCTTCCCGAAGACCAGATCACGACCCGCAGCAGCCGCTTCCTGGCCGCTGAGCTGGTCCGCGA
+
97;;)//,/9:6<>9<:988235.559<<<=<:::::;=>??966>>@CC?7>9=BB@AABBB::46;959;7;@C?;@C<BABBBAB@?BAA9A;?89:A7?555<=245:>2989949>5??=BBB8?235995>>59@8>2;1733,3377;;.3222255,222:322222'25380616612226676:9=79255579>@@B=@==@<://*.6269)...&.----2822,2:+25,5649;;6;755255555;0955598973767(,),,(,,25=<7889<49;5:<97
@MDX4E:00668:05839
GGCTGCCGTCCGCCGAAAAAGCGTCGCGTGTAATAGGAGACAGTGAGAAATGGCTCGTTACATTGGTCCCAAGTGCAAACTGTCTCGCCGTGAAGGCACCGACCTGTTCCTGAAGAGCGGCGCCCGCGCCCTCGACTCGAAGTGCAAGGCTGAAAACGTTCCTGGCCAGCATGGCCAGCGTCGTGGCCGTCTGTCCGACTACGGTCTGCAGCTGCGTGAAAAGCAGAAAGTACGTCGCATCTACGGCGTGCTGGAGCGTCAGTTCCGCGGTTACTACCAGGAAGCTTCCCGTCGCAAG
+
BABDFF?BBB@BB?@@@@@2ABBCCCCCAAAB@BBB>@BBBBBBBB===7<A?BBBB=;AA@@8;5;CC9C9>>=>>@9?DDAAA:<;:@AAA688:AA<BAC?BDD@C?CCC?BBBA@=@BAB=BAAAB=?BA@@>A?C>B>>=B?C>?B9999.;DD@D@@@?@?BCCCAA>A@BBBEDCB8949=AABBBAB?BBBB@@C=C>>?@===AA>=<////)//////(.55B?===;CCCBB@B>@A@@A=>9>@;;;?@@@;A=A:87:;?@@@A<??;?5;:>:>>9>??@@C<?
@MDX4E:00669:05818
AAAACTTTTGGCGGCGCACCGCGGCGGGATCAAGACGGTGATCATTCCCGAGGAAAATGTTCGCGACCTGAAGGAAATTCCGGACAATATTAAGAGTGATCTGGTTATTAAACCGGTTAAATGGATTGACGAAGTCCTGCAAATTGCGCTGCAATACGCCCCGGAGCCCTTGCCCGATGCGGCTCCGGAGATGGTTGCAAAGGATGAAAAACGCGAGCCTGATTCCAAGGAGCGAATTAGCA
+
CEE3;;:9&5.59477;00+/9:;;9959AACADCCD?BBA@A??<?K<A@A49:92<CB?ABBBBB?BBC@B@BE>C@C@C@BCCBCCC@B>BBAA??<<00,0<@@=DD<@=@<@;AA;AB=>B?DAAAC?A@@<@C;;;7;=BAA@@BCD?@AADCHE;C@BCCG>B>CBC=BAB;:;<@@@=@@CCBBA>B?A@@A=B>BCBCDDD2BBBDBCC@BAAA:@+0+0;@<>>@=@@BBEF
@MDX4E:00669:05829
CTCAGCTCCCGTGGAGGAGCGGAATTCAAAGCGCGCGCCGGGGTGCTCAGGGAAAGTGACTCCCACTCCAAACCTCTCCACTTGAAAACTATCCCCTGCAATATAAGCGTGGTCGATGCAAAAGCCCGGCTCGCTGGGGATTTCTTTTGGCGCGCGAGAACGTAGATTTCGAGCTAAAGCCCTAGATATCTCCACAGCATGTTGCTCTCTGTCTACCGAAACTTTCCCTTTCCAACGATAGGCATGCCACGTAGGCTTAGATGTAACATAGGTATCCAATAAATAGGTTTTAGAGGCAACCTCTGAAG
+
CCCBBBCCC>BBB@CC@CCCC@C>@?@EF?CBBCBB??=?DC:BBBBBBBB=BA:AAA@AAAB=BBBA@DE>@<;;;A;??B9:9FF;BA>>?DD5;:@C@CB@@>?BA00-0@00/89999.6661;;?@>;;:;A>-:8505@FD2C4>885>=9=@7=///=/86.597:@<@@6::;-...7999@?C:;;;887=@@68:?DA=>;:7<;;1799-5<90>91>>19496?858>=499/..)/;9:7?6?C@B>>>>>>;?>?@?5;:==8=:A>>9>AB;???/==7708@<@<=>>??<A
@MDX4E:00670:05820
GCCCTGCGGAGTCGGCATCTTCGTCTGGACCACGCTGCTTGCCTACAACCCCGGCAAGGTTGCGGGCAGCCCGCAGGGCTGGGCGGATTTCTGGGACGTGAAGAAGTTTCCCGGCAAGCGCGGCCTGCGCTGGGGCGCCAAGTACAGCCTGGAGTTCGCCCTGATGGCCGATGGCGTGGCGCCGAAGGACGTCTACCAGACGCTGGCGACGCCCGCCGGCGTCGAGCGGGCATTCCGCAAGCTCGACGAGCTGAAGCCCTATATCCATTGGTGGAAGTCCGGGCAGGACCCTGTGCGCGACCTGGCTGATGG
+
BBC<ABBB?CBBBC@CBCCC?BBBBBC?CC?CCCCBBBC>@?@BCBB?ABB8?=?C?B>B:==?<5<?:99/:AABB?CCBB>BC@CCD=BBCD>CBAABB?BCABBB=BD:?=?C?BBBBB?@>@BBBBCBDD9A::8;?BBBDCCB?BB?BBB?CBBB=ACB@@<@>BBCC?BBBB@AA@?CC?C?BBAAACCC?CCCCCB??;?@@999D>DC?B?A???BC>>>D9AAB8;7;?@=@@@A=>=A@@BBBA?AAE>GBABBB?BB?B>CC?C:>>=;AA:@>>:666-7>>??@@@@@=@@<@???AA;
@MDX4E:00670:05823
CGATGCTAGCGGCTTGAGTGGCATTGTGCCAGCTCTTGCCTGTGAAATCAGACCGGGTCCCACTCAGCGGGGCGTTATAGCTTTATGCCGGCTGTGGGAGGACTGAAGATGCTCATTCACATGGAAGGAGATTGACGAGCCTCTTTCTCACGTTTCAGTTCGTTGTATTCGCAGTACAGCTCGTACCCTTTCTTCAGCACTACAATGAGGCCGATTGCGGCAAACAGATTTTTCATTGGAAGCTCCTTTGGTGGATCCTCGATAGATTCGCTTGAAGGGGCGACAAGTTGTGTCGCTTGCTCTTGGG
+
CCCDBCCBBCB?BB@BAAAB@BBC@CCBC@BGCDBB?BB@BCCCCC=AACCAC=AA;AAC=BBBBB>>>A@2;;;7;>=;=<;2>>A>;><=AAABB=AB?BCCDD@DCAA@B??@>ACCCCC@C@C@@@@C?BBCCCBB>ABCC>CCCCC?A@:BABA>C@@=@BCC@CBBBBBBBCCDCCDCDCC>DC>CD@CCBBBBCCCC>BA;;6;?@@@?BBB@CDD>CBB;;;;;*<BB?B?B>@@DD@DD>C?BB@BBB@BABBBBBBB>B??@>CC?BBB5@B@BB??B=AA88:A@@<@??>>:=A7
@MDX4E:00670:05826
CGAACTGGGCGAAACGCTTGTCCTGGGTCTGCCCGTGGTAGTAGCGGTAGTAGATCTGCTGGACGATGCCGGCAAGACGGAACAGGCCATAGGTGTAGTAGAAGTCCAGGTTGTCGATCGGCGGGATCCCGGCCCGCTCGGCGTAGTAGTCGGCGAACTCCCGGCGGGTCAGCATGCCCGGCAGGTGGCTGGGCTGCGGCGGGTCAGTTGCACCGGAGCCGGGTCGCCGGCTTCCACCCAGTAGGCGAGGGTGTTGCCGAGGTCCATCAGCGGATCGCCGAGGGTGGCCAGTTCCCAGTCCAGCACGCCGATGATCT
+
ACB?ABAB=BABB>AFDF@CBB?BBB=BBBCEL>CAA>BBDBBC?><@BBBCBBBAA>::A>ACCBBAC@D@CC?CDCC@CABCC@C@CBCC@CCCCCBBBB?BBB?BB?B@B>>@@@@@<@@@7;:BD8?:>C;D==6635<<=:;:;;:?<AAA:>>CC;D=@@@:@@>>>AAAAA7>:>AA:@A7@@AC7><<>>9@@@:@A;;:=???A=D;??B7;;6;=>>6;7;@<@<??E:C>>>A;=<;;;3;AA<>>:>@A<@HACCCBCBB?BBB::8:AAA<BB?C?BAA4::2:@@B<?;BBBBB@BCCCB;;;
@MDX4E:00670:05827
CGTGCAGGTGCGGCAGGTTGCAGACGGTGACCGGAGTATCGGCCAGCAGGGTCGCGGCCAGGATCGGCAGCGCCGAGTTCTTCGCGCCGGAAATGCGGATTTCGCCATCGAGGCGGTTACCGCCGGTAATAATCAGTTTATCCATTGCAATGATCCCCCGTGGGCTCAGGAACGCTCGGCCCAGGCGGCGCGGCTGAAGAATTTCATGGTGACGGCATGGATGCTGCCATGGCGATCCAGGCGTTCAAATGGGCGTAGACCTGCTGCTGACGCTTGACCGGGCTCTGG
+
CCBDCCC@CCBC>>>@9>-00@@BBB@BEFC=?<@ABACCB?B@BBD@@@;@BBBC?B?BBACBBB>B@@@BC@BA@@@CB?CDCCC?B?BB9@?8758CC=B@C?CCCC6616=9=98738A=C<<=:=A<>>A@@@=@>?=:;5;;;5:@BACEDD2BBBB999??C;><>CA>;;5;;1:>4;;5;;=A:?;??=A=8AC=AACA=@@@A>:=?==188??@@@=@==8888=<9=?6;;=9;;;3;?A7@>>=<;;5;??BEBCCBC:::?B::3:?5=??AA?
@MDX4E:00671:05810
CCGGTGATTTCATCCAACAGGGCGTTGAGAACGCGATTGGCCTGTTCCTTGGTGAGATCGGCCTTTTCGGCGATAGCGGCGGCTAGTTCTGGTTTACGCATAGTTGCCTCTTTGACGGTTTGTTGTTTTTGTGTCCGTGCTGTCTTCCCAGCAGCGCTCAAAGGCACCGCAGTCCACCGGAACCATAGGCTCTAGACTGCGGTAGACGCGATGGAGGATGGCATGCTCCCGAGGACTGCGCCAGTATCGTCCGACAATTTTGCCGCAAGTCTCGACGGCATAACGGCCGGAACCAATGGCAT
+
C?C@CCAAA<@B@B?C?AACD>BCB?BBBB?BBCCCC?D@C@CBB?B?C@C?BBBBC;<<@C>BBC:BG?BBB;;;BB?BC?BBA:;:;DD?CC=AABCDCDCFAFFACDDD?DBBB?BB;@@?BDDGF5CBBBB@BCAAAAAAA>AB:??CBBB?@@BBA5949::;BBBBBDADE@CAC?C@DDCB?CCCCCCCCCCBC?BBBBBBBBBBC@CC@CCC@BBBBCCCC>CAA>ACCCBBB>BBBB=>>@@<@@6616@>///9>9959>@@A@???=??=>:;;7;=C=B<B;@;BA?CCC
@MDX4E:00671:05814
ATTTCCTGGCGCGCGGCGAAGATGGTTTCCTGGGTCACCCTGCGCTCCGGCCGGGCCTCGCCGTTCAGTGCCTCGCCACGCGCCTGCTGGAGGATGCGGCGTTCCACCGAGGCCTCCGGGTAGCCGATCTTGACGTGCATGAGGAAGCGGTCGAGCTGGGCTTCCGGCAACGGGTAGGTACCTTCCTGCTCGATCGGGTTCTGTGTCGCCATCACCAGGAACAGCTGTGGCAGGTCGTAGGTGCTGCGGCCGACCGAAACCTGGCGCTCGGCCATGGCTTCGAGCAGCGCCGATTGCACCTTGGCCGGGGCGCGGTTGATCTCGTCGGCCAGCACCAGGTGATGGAAGATCGGGCCTTGCTGGAACACGAAGGTGCCGGTCTCCGGACGGGTAGATCGTCGGTGCCGTGGATGTCGGCGGGGAGCAGGTCGGGGAGTGAACTGGATACGGTGGAACTCGG
+
CCC=B>@@;?A???@<@?B@CCCC?BB=A?A@@8?:;;;0;AADBBB@B@CACG=C?CDDE@CB@CCDDCC@B@@A69:@???@BBBAA>AB?BBBBB@BA><@=BB?A?>9><@@?CC=ABBB@BBAAA>>>@AABA@ABAA<@9>>>9>>>?<;;=>6//,/9=7<=6===8=@A<AAA<A<A<???@@@@A??>8?:=>9;;=///59;;<<7==:=:?>;;;@AA=A@@<@@?>661///<;=;3=:=>>=<<<5=:>><@A@@>=:=<;:;=AA<;:;=<<>===8=AA<>>BG8;7;<>5;;:/;==?;?<A@@<;;----+-0667<<6==:=>>>>;><AB>>>A:A<?<?A@@<@<@@A>>9=:=@B=A=A@@@7:3:777-7=>99677==9:::59//+/777:606<==2777;7077;<;-/..66478>5>>;<947827;@:;;=
@MDX4E:00671:05816
GCGTCGCCAGGGTTCGGTCGAGTTCCGCCAGCAGGCGCTGGCGGGCGCTGATCTCTTCGCGCAGGGTGTGCTGGTGTCGTTGCAGGAAATGCCGCAGGCGTTGCGGGTCTCAGCGCGCCATCGCGTTTCAGGCGGTCGATTGGCTTCCAGCGGAACGTCCAGCCGGCGCAGCGCGAGTATGCGCGAGAGCTGCTCGATCTGTTCCGGCCGGCAGTAGCGGTAGCCGGTTGTCGCTACCGGTGCGCGCGGGGACGAACAGGCCGATGGCGATCGTAGTGGCGAAGCGTCTTGGTGGAGATCTGCGAAGATTTCGC
+
CBBBCBB<ABB<B@BB@BCCBBB>B??@=@A@@@?@B@BB>BBC=9:9BB@BBCCC<@ABB@BBB<BBB@@@D@CBBBCC>BCCA@CC>AAA@CAAA?@??9?A@B5@000//:;<6615<;44444(4<@7>?:<<;77-78;8486::::49/3337,338284668<334:::::==;@B>@=<;???====@@@@A@@<?5;5:8;6<;<<555>.5.39(.(.2677998885:3655././///'.8::*//8060658A;<<=AA=777--+--94936:88160/-)-22263323346555,565
@MDX4E:00671:05823
CCTCGCGGAAGGTCCGGCCGGCGCCGTAGACCGCCGCCGACGAGGCGTAGAGGAACGGCACGCCGAGTTCCAGGCTGCTTTCCAGCAGGCGGCAACTGTAGCGGTAGTTGTTCTCCATCATGTAGCGGCCATTGCTTTCCAGGGTGCTGGCGCAGGCACCCTGGTGGAACAGCGCGCGGACCGTGCCGAAGTCGCCGCGGGCGTAACGCTCGAGGAAGTCGTTCTGGTCCAGGTAGTCGGCGATATCGGCGTCCGCCAGGTTGCGGAACTGCTCGCCGTCGGTGAGATCGTCCACCG
+
C@CCBBC@C?C>CC@D@C?B?CCC?BACBBB?CC@BB?CCCB@@>@BBBBBB>B?BB>A@@AC>BBBB<@<?@<?CCCCC=C@CCA>=98839A?BCCBBBBB?BCDB6::=;>><>AAA===A<9937)//169@@6A:ADD;???>=:>B@@?9>666-7<9<>;>=BB:::???B=AB:==??;?C=C>==><@???9===A=AA?A>@@A;A7<;@@@;???;>>9>@:A=>>>><>>A@ABAA<?>>><@A<==:>;A>><@=A?>=>>>>8<<>A;@@@@@===>@;AA:>
@MDX4E:00671:05831
CACAGGGAGAATTCTCAACCAGATCCGCACGCCCCACCCGGTGTTGTAGCGTGCTTACGGTTTGGCGATGAGGCGAACCTGCATCACCAGGGCGTACTGATGACCGTCAGTAGCCAGCGGGGTGAAATCAAAGTTGATGGCATTATGTGTTCAGAAGGCTGGTTTATCAAGCAGCGCCGGGGTTTACTGGCCTGTGG
+
ACDDFE=@A@@C?BB:9;;@GBA::7:>>A<;;;.;BC=DFJBB?BBB@@ABBDD=??A>@?<?<@?A@@@A>ABB@B?BCC=@@A@<<>>7999BBBBBBBBH>AABBAA>>>=AA???=2=:::2:CCC<???@@//,/9@<==>===<;;;@=A<A??;??9?@AA=@@@??@B<@@@5@D7=>>><>>BA@=6
@MDX4E:00671:05834
ATCGTCGGCGATGTCGCCTTCGCGCTTGGGCCCCAGCCACTCGATCAGCTTGGGCGAGAAGTAGTAGCCCTTGCCTTTCTCCTTGTAGCGGCGGAAGCCGATGACGTTGGCATAGTCGGTGTTGATCACCAGTTCGCCGTTCTCGAACTTGGCGAGACGGGAGAAATCGTACTTGCTGGCGTCACCGTAGGGCGCCATGCCCATGACCTTGAACTCGCCGTCGAGCATGTCGAAGCCGAGGTACTCGGTGATCGCGCCGTACAGGCCGCCCAGCGAATCCGGATCGTAGAAC
+
CBCCCCC<@@CCCBAA@?D?BB@@@B>BB7;;;6;BB@CBABCCCAABCD?BB>BBBBC@BBBBBAA@D;C>AA?BB=BCC?C?BBAA>;59;:A?AA=@=?>;AAB??=ACCA>>BB><><;@BBB>>:<=>9;;;;AA:>?@AA:==:<<?A=<<<<<1<<<=5=??BB@@;?====AAAAAA9>><==5<>>4;977919>@@@;?=AA<=;=AA:@?>>A???>>>>>>;<=:<>>9>@?;>>:9;;=666<;3>=<<;;06069929ED==666169=@BAA===;@
@MDX4E:00671:05835
GAGGGGCCGAAGCCCCTCTTTTCAACGACTTACAGACGTCAGTAGAAGTCTGTAGATCATAACTTGGAGCGGGAAACGAGACTCGAACTCGCGACCCCGACCTTGGCAAGGTCGTGCTCTACCAACTGAG
+
B:;;;*:7B@9AABB;ACCDD9AA?CCCBB>AABBBBCCBBBBCCC:;;BDCBBBBBBCCB?CCAC?AAACD<AA<AAABCBECCC?BCCB@??BBB:CBB?B?C@BD?B@BBB??@@BB@B?A7::AAA
@MDX4E:00671:05851
TTCGGTTCGCATCCAGGCTGGCCCGACGGCTTTCCGGCGTTTCGTCGCCTCGGGAAGACACATCGGGTGGTACCGGATTATAAAAGACTAATCCTACGTCTTTTAAAGATTTGTCCGATCTGCGGTGTCATGCAACTAGTGGCGTTGTGCCTTCCTTGACAAGCCTTGCGGCATGCCACAAGAATTTTGCCAACCTTTCGAGTCATCCGATATTCATCAATGGCTCCTACAAGATCCGACGGAGTGGATCTTACAAGCGAAGGTGAGGGCCGCGCAGCGGCTCCGATGATAGGGAGATCGTCACCGTGCTGGATGTACCCGTTTTGC
+
A<AC@C@CCCC??>?D=@8:4:=6?=@@>@@@<A?C@CBBB>BECDCC?BACD>D?ABBDCBBA@@<@B?BCC?C?BB?@@@??2?@?@A>BC?BAA@@9999*:@8ABDC=BBC@BBBBBBBB?BBAACA?A@ACCCGCB?BBB=AACDAD@D@FABBBC@BB@B=@AD?CA@?@<AA>;>>2989-7>:A?D@DD<CBBBB???A?A@BBB?BBBBB?BB=AAA=AAAA:>=@@<@AAA<?>==:=A@@<@@@<>>>B=B;>>ABB:B8;;==?A>>;>AA<AAAABBBCD=BABCCDCBCC@CCBBBB?CCCCDEE=BBAA:AB
@MDX4E:00672:05819
CGATATCGAAGGGCGGCGTTCCAGCCCCTGCCGGCCCTGGGCCGGAGATCCGGAGTGCGACACCGACGGCAGCCGTCCGACCTTCATGCAGAAGGGCAACACGGTGTTCCTCCTGCGCGACATCGTGCCCAACCCGGCCGACCCGGCGAACACGCCGAACCCGCAGTACGTCGGCCTGGCCTCGGAGTTCAACCTGCTCGACCTGAACCTCGGCTGGGATGCCGAGCTGCCCAACGACTTCAAGCTGCGGGTGGCCGGCAACTACGTGCACAACCTGGGCTACGACGAGGGCGACATGCGCAAGCGCG
+
:CBBBCBBB?AA>AC@CAA>@?A@@@A.=>?3949A8?AA,:49=>@@?>=D<>>@@A:;;??>A>=>9<>==8===8=>>5:7;>?????@;>>89;7;@@@=AAA<A2::9>=8:9:;;;;??===B9?:?>3:5:9=<<<)818::4;>>@B?@?>?F>DBA???AAA::39478076<=?====;>>:>:=CE?@?>>9=>B?B?BCB=@><=3==<8496///<<=2<7?889A;>>8=<<<888)880/1717@9:///=>776>=:==???9??AAA>><677-8==>>?A>>=@<@AA??
@MDX4E:00673:05810
GGCGCAGGCCTCGACGTAGACCAGCGCGCGGGCGGGGCTGGAATGGAAGAACCGCGCGCCCTTGCCGCTGCAATGAGTGTCGAAGCGGCGCAGCGGATCGTCGCTGATGCCGCAGTACAACGCGCCGTTTTCCGCCCTCACCAGGTAGACCGACCAACACTTCCTGATCGCCGCCGTGGCGGCCGTCGCCTCACTCACTCCAGACCCGCTCCCGCATCCGCTCGCAATACGCCACCAGGCGCGGATAGCCTCGCGCCACATGGCTGAGCGGG
+
DABA@@@=@?ACCBBBBBBAC?CAAABABCC>BBBB:B;;7;<??=B=@@<@<CCB@A@@<A?CB?CAACCC?BBBBBBBBBA>@;A9>@?=><A=A>=;A@@A>>=;<;=BB>=;=AA<AAAA>97667(88==>3;;>?79:;A8::B?CAA=A=??>A;A;AAAA>>>;>>9>;949:.5.8A<==<@AAA>>>A@@<>>>>?9?@@@@9>>>BB?BAA@<<<6==?>A:==;>A;@;:<<@@@;:8;@@@@A=AAA>?:?@>>?==C9
@MDX4E:00673:05855
CTGGCACGAAACCTCCCCGGCCGTCGGCAAGGCCCAGTTCCCGCTGATCGGCGACCCGACCCACCAGCTGACCAACGCCTTCGGCGTGCACATCCCGGAAGAAGGCCTGGCCCTGCGCGGTACCTTCGTGATCAACCCGGAAGGCGTGATCAAGACCGTCGAGATCCACTCCAACGAGATCGCCCGTGACGTCGGCGAGACCGTGCGCAAGCTGAAGGCCGCCCAGTACACCGCCGCCCACCCGGGCGAAGTCTGCCCGGCCAAGCTGGAAGGAAGGCGAGAAGACCC
+
CCC?@BACCE>B?BBCC;C@C@BBBD@BB?B?CC>BCB?BB<AA@@@@@A=@@;;;6<EDE>CCADDCCCCC@B>BBB>B>AB7;;AA@@@9:::5:<A;?@?B?B>BA?CC=BBBACB@CBB?B@CCCBA@@B;?>9@<?<@@@@BGBBAMABCB@BCCCCCDBB?BDBB?B?BCCCAAAAFE=A>?BBBAAA@BBBBBB?BCCBBAC?BBCCD?A>A?BBD=CC>?BCCADDA;;;/;;;/;C9@AA>BBCBBBB<@=@=A<;;;A5;5::=:=;?BBBB?B???:
@MDX4E:00673:05857
TGCTGGATGAAGTCCACCGCGGCCTGGCCGACGATGCCGCCGTCGCTGCGTACGGTGCCGCCGGCGACCAGCACTTCGAAGTCTTCCTTGGCGCTGAGGGTGGCGGCCACGTGCAGGTTGTTGGTGATGATCTTCAGATTGCGGTGGTTGAGCAGGGCGCGGGCGATGGCCTCGGTGGTGGTGCCGATGTTGATGAACAGCGAGGCGTTGTCCGGCACCAGGCTGGCCACGGCTTCGGCGATGCGCTGCTTCTCGTCGCGCATCTGGTCGGCGCGCATGGTGTAGGCGGTGTTCTCGATGCTCGAATCGTAGGCCGCACCGCCGTGG
+
ACCCCACDDD?CCB@A@>A::8:?BB@B@BBBC??>C?CB@CCBBBCCDECIBB?AA@@HF@C@C<=;@CCBBBC?CCC@AAAB?B=?=?>@@@?@;;;0;;5;:49;@@ABAA@C@C?BB@E?CCCCCA@?A@DDDBB?AAA?@@=??BCCCCBB=BBBBC>BBBAA=@=A@A=@B?AA>A@@=AB?AA<@===@699FBCBB?BBB>@@@5:7;>>;>D<??B?B>AAB?BB?BC>A???CDD???;;7:======@@@@@@AD9<<?<AAAAA<<<=AAA?>8::5:>=<>>>>>>>>A@@A=B>>=@A=A8<<=>;AA:>>>:
@MDX4E:00674:05832
TGCACGGGCAGCGAGGCCTTGCCGCCGGCGCCCGCAGCGGGCCGCGAGCGGCTCACGACGTTGAGGTACGTGGCTTCGTCGATGTCGAAGTACACGTGCAGCGGGTCGATGGACACGATCGTGGTCAGCAGCGTGGCCGCGCCGGCGACACCGCCGCTGACCAGGTTGCCCTCGGTCACGAGCACGCGGTCAACGCGCCCGGCGATGGGCGCCGTGACGCGGGCGTAGGACAGATCCAGCCGCGCCGCAGCGACGGCGCTTGGCCGCTTGCACCTGGGCCTGGCGCGCACTGCGC
+
BCCBAEC>CCCCC??<@?C?BC@CC>@<@BA@<BBBBBBB<B@BBBBBBB>BBA@>@;;AA<?>>;?@?;=;9>>:@CCC;888<<?A;@>@AA>>>;<<A99909<9:;?>CC@@;;;>>>?<@A>>=AAAACC;A6<9AC:@;=>999966717====?<?B;?:;;;1;==8=AAAAA@@?>>@@<AAA=@>@>>>9><?:::@?8?:96:@AAAC>>>9>AAAD=A?>??AA<AAA=@@>A;@@@@99978388886><@<@@@<@B>><>?A8?<>>;>DAA@?>>><<<
@MDX4E:00674:05833
GGTGGCATTCAAGTTCGCCATCGCCGCGGCGATGACCGGCGTGTTCTCGCTGGTGGACGCCAGCCTCAACTTCCTCCTGGTCGCGGTCGGCGGCCTGGCCATCGGGGTGTTCCTCAGCTGGTCGCTGGGCCGCATCCGCGCCTGGATGATCTCCCGTGGCTGGGACGACCCGGCGACCCACGTGGTACTGATGCTGTTGCTGCCGTTCGCCTCCTATATGGTGGCGGAACACCTGGGCGTCTCCGGGATTCTCTCGGCGGTGGCGGCCGGCATGATGCAGAGCTGGGTCGACCTGCTGCC
+
CACC@CCB?BCABB@@@A=@???<9?88299:9?>?@C?BBB>>9>@@=?@@<:96;<>>8>=A;A=>:=?=A:>>7;;=BBB=9299:4:=5;5;?7=:==@@ED3>>><A<>;::A::7;@A?@>>7>:@@@AA;AB=;:;?<???@??<<=7=??<@@@@9@A:;:A:A=A<<<D:AA>>?=AAAAAAA===AA;@>><<:<?;8:85;@;@>A>>><=<8>=8=:@@B@BCC>CABB>@6;;16717AA@@B?BB?A@=@B?A?B@BBBBBBBCBBBBBCCC>BB@AA@CAAABB?
@MDX4E:00674:05840
GCCCAGCACGTTGAACACGGCCTCCGCCACGTCGTCGATCGTGCCATGCGTGACCGCATCCACCGGCGAGCGACCGCCCAGGCCTTCGAGCGGTTCGGACAGCGCGCGGTAGATCGTCCAGTGGTCGATGCCCTCGACCTCCTGAAGCACGGTTTGGGTCAACTGCTGCTTCACCGGGTCGAGCTGCCAGTCGGGCAGCTTCTGGCCGCGCGGCCCCACGTTCAGTGCCAGCAGCCGACGGGCGAGGATGTCCTTGTAGATTTGCTGGCGCGACTTGTCCGCCAGCTTGGCGAACTCGGCAGGCGGCGATGACGTGT
+
BBC?BCBDDC>:BB?CCBB?BABA>AD?CCCCBBB@B@BBB88?AC???::7;B7BABBD?B@<B>>>BBBBBB?BBB>??;;5?;?CBB>>:>=BC<???::;????<A@@A?>@??<?@@@<>>AA@@>C:AA>>><>>;?>>:>;;;C?CE>BB=BBB@CAAAACBA?CBB?BC>BBB=>>?BB?CDBBBB>C>>>?<?@@7:7:>>>>;>@?5?>A@=AA@BAB>B>@@A@=@@@AA9>>AA=BAA==:<:>@@AAAA9AAAA=@=<=>>C<??A<AD;>>>=<A<@;;5<A8869;;4-,(,,,2,,,,,,6
@MDX4E:00676:05815
GGCCTCCTCGGTCTACGGCCAGACCCGCCCGGCGGCATGCTCGACATGGTCAGCCTGCGTCCGCAGAACGTCGCCAGTCACGAGGTGAAGGCCGAGATCGGCAACTACAACCACAAGCAGATCAGCTTCGACAGCACCGGCCCGATCGACGACGAGGGGCGCTTTCTCTATCGCCTCTCCGGCGTGGTGCGCGACAGCAACACCCAGGTCGACCATATCGACGACAAGCGCTACAACATCGCCCCGAGCCTGACCTGGAACATCGACGACGATACCCGGCTGACCTTCCTCAGCCAATTCAACCGCGACGATACAGCCG
+
@:A=AA=ACC=AA<?55248=<797*///(/3//(/9;@A@@@<>000)/668>;@@:::>5>>>@@?@BACBC7::??AAA;;5:><1839=AAAAA9949529/:;<*0*/774:;;;>=<=943-399;;>?=><@299,99=>9@994==9999*94337/8?9@BB>>>?@A?@9>9=>=>9==BABBCBAB>?<??>A7;;6;??>><>>>>@BB>>>>A=CA?>?AAA<A?<<8887)8;7818=<<:>B>F:=>>==>>;88888888-86=CCCC@B?B?BECDD?B<?<?A<@<AAABBBA@;;;@@@D
@MDX4E:00676:05833
CGTCCCGGTATTTATCCAGGCCTGGGCGAGTAAGTCCGGTAACGCTGGATTCGATTATTGGCTATCAGGTGACGGCATGCCGTTGAAACTTCAAGCCGCCCAGGAGAAAGCCGCTTAAGGGTCCCGGCCTTTTTCGGCGAAAAAGGACGGGTAGGGGATAAGCATGAATTTTTTGGGCTGTGACGGTGTTTGGCTGGCCAGGGAAGATGGTTCAACTATCTGTCAGGGTCAAATGAAGACTTTTACGGTCCAGGAAATGCGGGAGTTCTTGACTCCTGCAATGACAATTGCGCAGAAAGCTCA
+
CCCEF=B@BBB@<@A@?BB?D?BAD=CCCC999:B@=B@CC?CCCCB@??=?CCC?BB?CADCCBCBB?AABCC@CDCCB?BA>@AD>DB>AB>BB?BBB<BB>AAAB<BB>BBB>B>BB7==B9@<@;:<;;+8818<====.=<@CDE>CCCDE=GCC@CCMDCC=B@@@A*BG?CCCCCCB@=@A@@<A?BCCAC@CIG>B@BBBB@D@CC=AACCBAAAABBC>BBBC>BBB@CBBBCE8CCB@CC@BB@BB=BA?CC>B??<?B=?BCBB?AAAB:??AAA=C;::DCCABB=ACCBB
@MDX4E:00676:05843
CTGCGGCACACCCCCACTCCTCGTCGTGGTAGGCCATGTAGAGGGGATCGTCGTTGCACCAGAAGCAGCGTGGCATAAGGCTTTCCGTGGTTTTCCAGGGATCGGGGGGACGGGCGAGGCGGCGCGGGAATCGGGTATACTTCCGCGTTTTGTATCGAAGCCTCAGCACAGGTGAATTTCGTGAGCCAGACTACGCCCGCCGTGCGCACCTTCCAAGACCTGATTCTCGCCCTGCAGAACTACTGGGCCGAGCAGGGCTGCGTGGTGCTGCAGCCCTACGACATGGAAGTGGGCGCCGG
+
CCCBCACCC?><<<);;?>>AAAC???><???<A@CCCCBCCBBB8BBBBBBBB?BBBB?BCC=??BBBC;;7@BBB=@=@@C@F>B@@<@BB9@9@@B:@>9;;;;:%<<<=6>===<@@<@@?>?9?;A555.6=;?@?=B=A>9977,9;<>A@@;@B>BB@@AAA>A;??>:??7>>>>>>>;AAAA>>CBBB<BA?BBBBBCBB?C@D@D@BBB@BBBB?CD??>C>BB@ABB@B>>ABBB=C?BBCCCDL>DBBABBB@AAAB???CCD>CCCCBBBBB?B???AE7:;;:><
@MDX4E:00676:05858
CTCCTCGCGCTTGAACAGCGCCGCGTACATGGCCGCGGTCTGCCCTGCGCCGTTGCGCTGGTCGGGGCTGCATTGCGCGCCGATCAGGCGCCGGGCGATGCGGACCTCGCCCTTGAAGATGGCGCCCCATCAGGGCGGTGTTGCCGCGCGCATCCCTGGACGCAGGGGGTCGGCACCGCCTCCAGCAATTGGTTCCACCGCTCCCGCCATGGCCGTGGTAGGCGGCCAGGATCAGCGCGGTATAGCCCTTG
+
CCC@BCCBCCC?CD@BBBBBB?BBCCCDB??<??BBB?AA@:990;;9:><?B=B=>>;=7;AA;;.A858882662576.6:><9>:<>>5;;3:9:?>>><>?9?;798.7066169;=399989-8876:;+-,0622)---26999?A===/6;299=;:::::.:::7=>>:>?;<>;==<=8=2708396?@597353-33.335/527782775499.3.38288=>@>??C<CBAA>>>9>:=
@MDX4E:00678:05813
CCATGGATGACCGTTCACCGTACAAGGAAACCCCATGCGCAGCCTTCTTCTCTCCTCGCTGGCCCTGCTACCCGCCCTGGCCCTGGCGCAACCCGACGCCTCGAGCTTCCCTTCCTGCCTCGCCGGCCTGCAGAAGAAGGCCCAGGCGCAGGGCATTTCCGCCGACAGTTATGAGCGCTTCACCAGCGGCTGCAGGCCGACCTCAGCGTGCTCGACCTGCTCGACGCGCAGCCGGAGTTCACCACCCCGCTGTGGGACTACCTGGCCGGCCTGGTGGACGAGCAGCGGG
+
B?BBB?BBBCC?CE;;<FABDCCC9=9=;6<??3@@@>??ABAAD?BB@AAA@@<@@@>>>8<=6<<;;888.8980:;<BB:>@;@AAB:>;29?9:8<@A>>>>?8==7=:?<<=B@@<<>-0+0?@BAACI@BB?A5<<0;@;>>>@@@;@BCC?C@CD@CBCDCB=@??A@@AAA=A@@;>99920/9://(/(/./*28::98888=98:?<????@CBBB???CBB?C>99:?BCC989DE9BABB?@D9BBB>>:;:5:8=8>=?@=@A=???:8;;ABBB=
@MDX4E:00678:05858
CGAAGCTCGGCGCGATGATGCCGCCGTTGACGATCAGGAAGTTCACGTAGGAACCGGCCAGGCGAATGGAGGGATCGCGCGGCTGGCTGCCCTCGACGATATCCACGCCGTCGCACTCTTCCTGGGTCGCGTACAGCGGGCCGGGGATCGGCATCTTGTGCACCACCAGCTTGCGTCCCTTGGCGTCGCGGCTTTCTTCCAGCACGCGGAGGGCGGCCTGGCAGCGCAGGTAGTTCGGGTCATCCTGGTCGTCGGTCCAGGCCAG
+
@ED=BADCC?AABBBBBB@BB@BB=AB?CBB?@>?>@;B:888;AAAAAA:@6868;C;8868A?;AA<AAC9AA@@@>>A9>>>9>>;;;6;@A>>>>A>==:>>AA;AAAA9@@C?@<@;99929=<=>@???@?@?:?<ABB5A?::69AA>>;>A@@@A<AA=B@@@8???@AA9A=A<@@@::;:5788-8?;@=AAAAABAA:///)//)/79;4<@??AAAA<>>=?<@DD9>>AAA=BB<@???::5:@<@A>D<>=
@MDX4E:00679:05829
CGAAACCAGCGGCCTCCGTTCGGCGCGCAGCGCGCTGGACCTCCTCCTGCTTCGCCTCATCTGGGCCTCGACCAGACCAACCACGAAGAGGGCCTGGAGCGCCAGGCCGACGGCACCTACCGAATTGCGAGACCATGACCATGACCAAAAACCAAGTGAAAACCAGGGACGAGACCTGCCCCGTTCACGGCGGCTTCGAGAGCAAGCAGCAGGAGCAGTTCGACGGCGGGTTCGTCTGGACTGGATGCGGGCGCTGCGAGTTCGAAGCTCGCCAATCATCCGACCCGGAGGTTCGCTCCAAGGCTCAGGC
+
@9994;>ABBC@D@CC?BB?@?;?A@9:;??@AABCC@BB@AA=@@;?@@@?AAA>ABBAABBB>B@CBBBB9:8AA;A:=7;;@?;====6=5;;;;;:==9:;5::====8=>>6;;A<AA=@7;<A@@@C?BBBBB7;>ABB?BBBB3B?@<???AAA5?<?@A9?>>>;;B?CCBBB7BB<@@BB?;;6;:=ACBBBBBC@CCBBBBB?AAACCC@BBBAA=???5>?A>??CC@CCCC@CCBBCC=BBCCCBC@996:@@=AB@@@D?B?BCDBB@@@@C<A>A@=@>???A@>A;?;?998=:=
@MDX4E:00680:05838
CGGCGGGGCGATCTCTGTCACTGGGCCGCGCTCTGAAGCGCGGCCAGCGCATCGCGTAGTCCCTGCGGAATGGCACCGGGCGGCTGCTTCGGCGCTCCACGAAGACATGCACGAAACGCCCGGCCGCGCAGGCCTCCCCGCTGCCCTTCGA
+
55.5555&5999B?@A@:66<==>8>9:::;;;3336888888B6@AAA@@947B@@@=666.//.5.2,29*..949;.576::9996;;37222936622,255555555222'2555,5+2+25555;:@77:99)552222'2.552
@MDX4E:00680:05843
CCGCACCGCAGCGGCGCATGGGTTCGAACCAATGGCGCATGCTGCGCGAGCCATCGGTGTCCTGGTTGCCGTAGCGCGCTTCGTCGCCGGGCGCCTGGATCACCTTGACCCGGCTCCAGTCGGCCTCCAGCTCGTCGGCCACCACCATCGCCAGGCTGGTGCGCACGCCCTGGCCCATTTCCGAGCGGTTGCAGACGATGCCGACCGTGCCGTCCCGGTCGATGCTCACGTAGATCTTCGGGTTATCCACCCAGCCGTGGGGCATGGCGTCGGCG
+
C@CCBCADBBB::8<ABBBBG=B>@AA?A=A=AB?BCCBBC?>ABBBBAAA@BBBB?BBBB?BF@C?BA?BBBCBB@???:?AAACC?CC=@9849@?ABBAA?C@CCCC=C>@@><??>//,0:@@<@?CDC??00,0,00=?@9>0//>><9:===8=>>>>>====8=E=BA:>>=8=8<==>=1818<=>;:;=;;;:===;@?;:4;===8=>AA>><;;>>@BCA@>>BCC@BBB>B@AAA@B@@9===:>AAAA3ABCC@BB>>@9<:
@MDX4E:00680:05856
CCAAACAACGCTTCAGCACGCGTAGTCTGATTGTCCAAACGTTCACCAAGCCCAGCCGGTACAAGCTCACCTTTCCACCGTATGCGTGACTCTCCCTCAGCCGGTATTCCCCCAATGGGGGCGAACCGCCGTTCAAATGCGGGTGGCCGGCTTGAAGTCGGATAGTCCGACCTCAAAACCGGCAAATCGCCGGTTTTGGATCTCCTGCATTGCAGGCAAAGGCTCGCTGCGTTCAAGCGCAAATACGGGAATATCCCGCATTTGAAAACCCGGCTTCAAAAGTACGCAAAACGTCCTTTTGACTGCGGACGAAATTCG
+
B6;;6;;5:CBB@AAABBCCCCBBBBBBBBB@CCB?BE?BBA?BCBAFABBB>BBB?B?BABB>9:9BEF@CA>A;==9ACA@@:;;?>>?>?=A5;876?:?:=<;38888)>9??DDD3BAA5949@?A>:89:2:???C>??;?=@=AB@DD=BA>>;<==<<A?BBB@AAACC9A=A=ABB>CCBB?B@CFF9;7?CCBB?BCC=>:=@@@=@>>3:7:?@@A@@?AA=AC<A>?@AA9?>==>6<8=><<=7=@@@A:@>>>,88)8:<<8=???5@?>==8888,8=>@=BBB5@CBBB::59B9997:?CC
@MDX4E:00681:05821
CGAGGATCCCGGCGTGCTCGTACTGCCCAGCGAACAGGTAGATCAATTGAGCCCACAGCTCTGGAAAGCGACTGAGCCAATCGAGTGCCGTGCGCGGTAGCAGTTGGTGGATGAGGAGTGCTGAGGCAGCGCCGTGGAGCTGGTATTCGCGGGACTTCACGTACTTGAAGCGGTATGGCTGGTTGATCGGTCCGTTCCAAGGGTGCCAGGTGCTGCCGTCCTGCAGCTCCACCTGCAGGTCTACGACGATCTTGCCTAGGTCGTGAGCCAGGGCACCATAAGCCGCGGCGGCTGACCAGGCTTCAGCCTGGG
+
CC@?;?@@@<A@CBBBABCCCCBBBBE=CBCCC@CBB@BCCBCCC@C?BAAAD=CC@A@CCCE@CD?CBA@BDBBAA@D@CCBBB????AA@AA??8>>>>ABA>?;==8=<>=?;>>>??@B@95@9@@AA9==A=?????<???<>>>@@9@BB=CA>>?ABB;??<AAA<AABD=ECB@C@CCCCC?BC?CC@E@C:::8:AA=BB@BBBBBB?B>>>@CBBBCCC<::9<<?>>:>@A@A???677@@9<=;@??<@;::@@;;7;CE;@>>:==B=??<?AA:===AA>>>=??=?A<@@@@<?@?9
@MDX4E:00681:05825
CAGTGACGACCAGCGCACCACGGTCGTGCAACTGCCCGAAGAAGGGGCCGTGAACTGATCGTCCAGCGTCCGCAGCCGCGGCGCGTTTTTCTTTCCACCCACCGGGGTTTCTCGCCCCGACGGGGCGAGGTGCCTCTTTTCCTGAAGGAGCCATCTCCATGTCCACCGTTGCCCAACACGCTTTTCCCAGGTTCAACCCCGGCCAGGTCGTCATGACCTCGGGCGTCGCCAGCCTGGTTCAACAAGGCCAGCTCAATCCCCGTCCGTACCTGTTGCGGCATCTGTCTGCCGACTGGGGCGACCTCGAC
+
CCCCDDCABB?BAAABBB>BA@=@BAAABD?DBAAD=BB@B?8>><2<=>;=;<;>;?A???@:@C>>>>:>>565<@@A=A@>::9:8)8;;1;:;<=5=>9>??2>A:AA;;;==/::::::/;;:;8=@@<@ABCB3?8==B>D:=<@<AAA>>:?>>>A8<<:>>:>>>9>=AAAAAAAA3@@9@A<A<A=/676,8:A<AA=A@??@>>>@?<@@@@:@<;;AA=@>?<AB<><>?;?A<>;><@@AAAA<:99:39AA;>;?A=B>=9=>>=A@@=??==?AA=AAA@>>>2>?>@;?<><@
@MDX4E:00681:05836
CTCGGCAGTTGCAGCAAGGAAGAGCTGGTGAACGTCTACGACAACACCATCCTCTATACCGACCACTTCCTGACGAAGGTGATCGAATTGCTCAAGCGGAATGCCGACAAGCGCGATACGGCGATGATCTACGTGTCCGACCACGGCGAGTCGCTGGGGGAGAATGGCGTCTACCTGCACGCGGCGCCCTATTCGATCGCGCCCCAGGCGCAGATCCACGTGCCGATGGTCAT
+
CBDC?@A;;8;BBABB@CAC?AABBDD?AAB?B9::@CBBC9979??9=>C>;;;@@@A<>>><?>>;?:;;;<<<8=8<>=>?>A6;7;??>A=>>><?=;;;=BAAA=????A@==>A;@<=<::9<==BBCBEE@DBB@BCC?BBBAAACCCCCCC2AAA?CCBCBAA@@@?ACABAA:;5;ABB;BCB>BBDBAA@@@@A7;;6;AABBCCCACCCDBB?CGAA>AABD
@MDX4E:00681:05845
CGAGAAAACCACGGACGGAACGACCCAGACCTGGGAGGACGAACACCCCATGGTCGCCCTCAGCTTCGCCGAGCTGCAGCACCTGTTGCAGACGCATTTCGAGGTGCAGGTCTTCGAACACGACTACGAACGGATCACGCCCTGGGCCGGCAGCTCCGGGAATGCCCTGTTCGTCTGCGTGAAGCGCTAGCCTCCGGATATCCTGGCGCAAACGTGACGATCAGGCTGGCACGGGCGGGGCAGCGTTTCACAGGGGGCTGCGGAGGATTCTTCGGTCGCTTTCGGCACGCTGCGTCCGACCCGCTAG
+
FCCDCCC;C@AAC@CCC?B>BABBC=BCBB=@?E>BB@BC@A=A@@A?3?::6;@@AB>DCBBBD@CCC@BBCBCBBBBCBC@CBB@BCCCCCCBBBB<BBA@=@CCCC@CCC@CAC@BCCFDBBBBCD?AA@AABBBBBB>BCC=B?B>AABBBC@DC493:>::1;>?;?@B@;;;@@@@;@CCDDDBB?CC@C?BABBC@BB?BA@@@:@A@@AABACBBB?@@A@BBACA99999+9@@@@AC>BBBBCDDD3BBAAA@BA<@@===7//)////;;8;C@CCFBCBBBBAA>AAAA;AAB??
@MDX4E:00681:05850
TGAGGCGTGCAGGACAGGCCCCGGTCGGTGGGAAACGTGCCAGCCGCTTCCCTGTAACCGTGGCGAGCTACGTAGGCGGTGGCGCTGGTAACGCTGCCCGGGCGGGCGCACGCTAGGCGTCGCGCCGAGCTGCGAGGCGCTGTCGGG
+
@AAA?B@@??AA>A=<=1;;;*98A?C?CDD>CC?CCCBC@BCB?CAB5<;09::?9A=????@?9::AB@@???;@@=AB?CBBBF?BD>@?BCCBC=BC;:::6;@@BCCDABB@BBA@AB>>9>AA@AB999B?BBAA@@>::0
@MDX4E:00683:05814
ACTACACGGTGGTGCAGAACCTGGCGCAGTTGCAAGCGATCAACAAGAACCTGGACGGCCTGTACGTGCTCGGCGGCAATATCCTGGGCGCAGCTATTACTGCACGGCACTGCAGTCCATCGGCGGCCGCCGGCGTCTTCAGCGGCACCTGGACGGTCTCGGCAACAGCATCGGCAATCTCTCGATCAGCAACAC
+
CCCCCCBB@BE@CCCCAA<>=?B?BB@BBB>BBB>BBB>>>C?BC?BC>A>@D=B@@>@?BCCBBBBBBBBA?7757A?ACCA;877+89:=??BBB?CB@@@@7778AA?@??>;<8<<993992939@;=8=867:7::66658//*/:65::9>>///1//)/66<:9782::;>>>===?===;;A@<@AB
@MDX4E:00683:05823
ACTTTTGTAAGAGCGATTTAACTCTTCTCACCCATTTGGGCATTAGGTTCGTCTCATCAGCTATTGGAGTATTTCGTTAATCATATCTCCACCTCCAATGTTGAGCGCTGTCCTATCGCTTGACACCTCCCTCCCCCGCTTCGATGATAAGCGCGTGATCCGCTGACGTTGTCAGCGACATGCCCCATGCAGCTCGGATCCGAAATGCTGCAGCACAGTCCACCGTGTTGATCCAACCCAAGACCGCATAGCTTCTGGTAGCGCGGTCGGTCGGCCTCGGTCGATAGAAGCTCCCTTCCGCAACCCAGCGGGGAA
+
CCCCC8AAC@BBBBBACC>C=BBCD=AACCCD>CC?6B<8BA?3540478=?BABAC@@000AA=C@CCCDCC>CGD@E@CBBBCCECC@BB?BB@C@BBB@CCBCCCBBBB?BDDBBBC@CCC:999CC>CCCCC2@@C?CCCABBBC?BAAAAABCDE@@A@BDDCD?BBBBBBBAAA@9000*00//?>=?7715::5<>A9>>?8:;>>AAA>>>A<@@8:8>>;BA?><>=@@9@:=994::@=>>A@<@=>:=@@@@><:<>>:>??<?<AAA:@AAAA;;;;@??@A9A;A;>==2872:=AAAB3?@
@MDX4E:00684:05843
GGCGAAACGAGAGACTTTAGCCTAGCTGCTTTCTTCGGTGTGCGGGAAGCGGCCGAGGCGGTTTCCCCGGTCGGCGCCGCCCCCATCGCCCAGGCGCCGGATAGTCCAGCGCTGCAAGGATACTTGCCATGCCTTCCCTCCAGCTCTACAGCGACAGTTCACCCAACGGATTCAAGATCACCATCGCCCTCGAGGAACTGGGCTGCCCTACGCACTGCACCACGTTCGCATCGACCATGGCGAGCAACGCCGCCCGGAATTCCTGCGCCTGAATCCACATGGCCGGATACCGGTGCTGGTAGACCGGGCCGCCGGCATCACCCTGTTCG
+
57;///)////7:A?A=7=CE@996;:9;95)5=9>>;;;554<:(3-376063///19=8==6<<<+8343429==8;8;;;+:///89188*/3715023266<.339;777//599;0///(383:<<<7:9<@99:6:==A::9A989857<7718///(/3883//)/7699>><<5<<<;=>4;;:;:/7/7557.75522'22556666779<5:7>>.65?=>:;:>;@;;6;A;;:=5;;>9==<5<8=:?:=8=>;;;9>AA<@@<@@==>:>:>;====:=;>>>@@<A@AAA=AA9><>>=A<@>AAAAA:>>=9<<
@MDX4E:00685:05822
GCGCCAATGATCGATGAGGCGGTTGCGGGCGATCT